A5040189891- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Sphingolipid Metabolism and Signaling
- Dermatological and COVID-19 studies
- Respiratory viral infections research
- Fungal Infections and Studies
- Antibiotics Pharmacokinetics and Efficacy
- Influenza Virus Research Studies
- Antimicrobial Resistance in Staphylococcus
- Infectious Disease Case Reports and Treatments
- Lipid Membrane Structure and Behavior
- Actinomycetales infections and treatment
- Infectious Diseases and Mycology
- Pharmacological Receptor Mechanisms and Effects
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- Blood properties and coagulation
- Streptococcal Infections and Treatments
- Animal Virus Infections Studies
- Urticaria and Related Conditions
- Neonatal and Maternal Infections
- COVID-19 and healthcare impacts
- Kidney Stones and Urolithiasis Treatments
- Vibrio bacteria research studies
University of Tokyo Hospital
2017-2024
The University of Tokyo
2019-2024
Ono Clinic
2019-2020
National Institute of Infectious Diseases
2019
Abstract Background A heterogeneous clinical phenotype is a characteristic of coronavirus disease 2019 (COVID‐19). Therefore, investigating biomarkers associated with severity important for understanding the mechanisms responsible this heterogeneity and developing novel agents to prevent critical conditions. This study aimed elucidate modulations sphingolipids glycerophospholipids, which have been shown possess potent biological properties. Methods We measured serum sphingolipid...
To evaluate the efficacy and safety of nafamostat combined with favipiravir for treatment COVID-19.We conducted a multicenter, randomized, single-blind, placebo-controlled, parallel assignment study in hospitalized patients mild-to-moderate COVID-19 pneumonia. Patients were randomly assigned to receive alone (n = 24) or 21). The outcomes included changes World Health Organization clinical progression scale score, time improvement body temperature, oxygen saturation (SpO2).There was no...
Among various complications of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), renal complications, namely COVID-19-associated kidney injuries, are related to the mortality COVID-19.In this retrospective cross-sectional study, we measured sphingolipids and glycerophospholipids, which have been shown possess potent biological properties, using liquid chromatography-mass spectrometry in 272 urine samples collected longitudinally from 91 COVID-19...
Abstract Several clinical trials have shown that the humoral response produced by anti-spike antibodies elicited coronavirus disease 2019 (COVID-19) vaccines gradually declines. The kinetics, durability and influence of epidemiological factors on cellular immunity not been fully elucidated. We analyzed immune responses BNT162b2 mRNA in 321 health care workers using whole blood interferon-gamma (IFN-γ) release assays. IFN-γ, induced CD4 + CD8 T cells stimulated with severe acute respiratory...
Abstract In Coronavirus disease 2019 (COVID-19) subjects, recent evidence suggests the presence of unique coagulation abnormalities. this study, we performed clot waveform analyses to investigate whether specific modulations are observed in COVID-19 subjects. We analyzed second derivative absorbance routine APTT tests using an ACL-TOP system. high frequencies abnormal patterns second-derivative curves that could be classified into early shoulder type, a late or biphasic maximum...
To better understand the immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with COVID-19, it is important investigate kinetics of antibody and their associations clinical course different populations, since there seem be considerable differences between Western Asian populations features spread COVID-19. In this study, we serially measured serum titers IgM, IgG IgA antibodies generated against nucleocapsid protein (NCP), S1 subunit...
Adverse reactions after vaccination with COVID-19 mRNA vaccines are common; however, the association between adverse and humoral responses is uncertain. To determine whether immune BNT162b2 vaccine administration were associated local systemic reactions, we conducted a prospective observational cohort study in single tertiary referral center. Healthcare workers who received first dose of recruited. SARS-CoV-2 anti-spike IgG antibody titers measured three weeks second information about was...
This study aimed to evaluate the antiviral effects and safety of nafamostat in early-onset patients with coronavirus disease 2019 (COVID-19). In this exploratory multicenter randomized controlled trial, were assigned three groups within 5 days symptom onset, 10 participants each group: at either 0.2 mg/kg/h or 0.1 a standard-of-care group. The primary endpoint was area under curve for decrease SARS-CoV-2 viral load nasopharyngeal samples from baseline day 6. Of 30 patients, 19 received...
Numerous studies have suggested that the titers of antibodies against SARS-CoV-2 are associated with COVID-19 severity, however, types disease maximum severity and timing at which associations best observed, especially within one week after symptom onset, remain controversial. We attempted to elucidate antibody responses in early phase disease, investigate whether testing might contribute prediction patients. classified patients into four groups according (severity group 1 (did not require...
Background: Several types of laboratory tests for COVID-19 have been established to date; however, the clinical significance serum SARS-CoV-2 nucleocapsid (N) antigen levels remains be fully elucidated. In present study, we attempted elucidate usefulness and N levels. Methods: We measured in 391 samples collected from symptomatic patients with a confirmed diagnosis 96 non-COVID-19, using automated chemiluminescence immunoassay analyzer. Results: Receiver operating characteristic analysis...
Acute renal injury is an important complication of coronavirus disease 2019 (COVID-19). Both COVID-19-specific mechanisms, such as damage to the parenchyma by direct infection, and non-specific pre-renal factors, have been proposed be involved in COVID-19-associated injuries. In this study, we aimed elucidate characteristics injuries, focusing mainly on urine sediment findings.We compared findings their associations with functions or urinary clinical parameters between subjects COVID-19...
Abstract Background Here, we genetically and antigenically analyzed influenza B viruses (IBVs) isolated in Japan during the 2017‐2018 2018‐2019 seasons. Methods A total of 68 IBVs (61 B/Yamagata/16/88‐like [B/Yamagata]‐lineage 7 B/Victoria/2/87‐like [B/Victoria]‐lineage) were characterized by using hemagglutination inhibition (HI) assays phylogenetic analysis, respectively. The susceptibility to neuraminidase (NA) inhibitors was assessed a fluorescence‐based NA assay. Results All 61...
Abstract Plesiomonas shigelloides is a gram-negative bacillus that commonly causes self-limited diarrhea in humans. We present the case of P bacteremia 49-year-old man with alcoholic cirrhosis who developed septic shock day after eating Dojo nabe (loach hotpot), Japanese traditional dish.
Non-culture-based fungal assays (NCBFAs) have been used increasingly to help diagnose invasive diseases. However, little is known about inappropriate use of NCBFAs. We aimed investigate NCBFAs in a tertiary academic hospital.This retrospective cohort study included patients who underwent testing with beta-D glucan (BDG) between January and March 2018 or galactomannan antigen (GMA) cryptococcal (CRAG) June 2018. Testing was deemed appropriate if the clinical presentation compatible infection...
Abstract Background Protothecosis is a rare infection in humans and animals caused by the achlorophyllic algae Prototheca species. More than half of protothecosis cases are cutaneous infections, most observed immunocompromised individuals. Case presentation We report case wickerhamii mucosa pharynx 53-year-old immunocompetent woman with an incidentally found mass lesion at left tongue base. Histopathological findings suggested cryptococcosis, but P. was identified from oropharynx scrape...
In order to identify therapeutic targets in Coronavirus disease 2019 (COVID-19), it is important molecules involved the biological responses that are modulated COVID-19. Lysophosphatidic acids (LPAs) pulmonary inflammation and fibrosis one of candidate molecules. The aim this study was evaluate association between serum levels autotaxin (ATX), which enzymes synthesis lysophosphatidic acids.We enrolled 134 subjects with COVID-19 58 normal healthy for study. We measured ATX longitudinally...
Daptomycin has been reported to cause artificial prolongation of prothrombin time (PT) by interacting with some test reagents PT. This was particularly prominent high concentrations daptomycin in vitro. However, whether this is important clinical settings and the optimal timing assess PT remain unclear.A prospective study conducted patients who received for confirmed or suspected drug-resistant, gram-positive bacterial infection at a university hospital Japan. peak trough tested using nine...