A5101728728- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Enterobacteriaceae and Cronobacter Research
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Infections and bacterial resistance
- Cancer, Lipids, and Metabolism
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Peroxisome Proliferator-Activated Receptors
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 detection and testing
- Liver Diseases and Immunity
- Alcohol Consumption and Health Effects
- Urinary Tract Infections Management
- Endoplasmic Reticulum Stress and Disease
- Hepatocellular Carcinoma Treatment and Prognosis
University of Tokyo Hospital
2016-2025
Tokyo Health Care University
2023-2025
The University of Tokyo
2015-2024
National Institute of Infectious Diseases
1997-2019
Yamagata Prefectural Central Hospital
2019
University Gastroenterology
2018
Tokyo University of Science
2018
Hitachi (Japan)
1993-2017
Hyogo Medical University
2016
Kawasaki Medical School
2016
Sarcopenia is defined by muscle loss and dysfunction. classified into primary secondary types, based on the cause. Primary sarcopenia mainly aging-related sarcopenia, whereas reduced mass strength that accompanies an underlying disease. Given essential role of liver in metabolism, due to nutritional disorders or other factors can frequently occur In 2015, Japan Society Hepatology (JSH) decided establish its own assessment criteria for disease because number patients with expected increase...
Hepatitis C virus (HCV), a major causative agent of non-A, non-B chronic hepatitis, is also suggested to be associated with extrahepatic manifestations such as mixed cryoglobulinemia and glomerulonephritis. Two independent lines transgenic mice carrying the HCV envelope genes have been shown previously express proteins in organs, including liver salivary glands, which results no pathological changes liver. Further analysis these animals now has revealed that they develop an exocrinopathy...
Transgenic mice expressing HCV core protein develop hepatic steatosis and hepatocellular carcinoma (HCC), but the mechanism underlying this process remains unclear. Because PPARalpha is a central regulator of triglyceride homeostasis mediates hepatocarcinogenesis in rodents, we determined whether contributes to protein-induced diseases. We generated PPARalpha-homozygous, -heterozygous, -null with liver-specific transgenic expression gene (Ppara(+/+):HCVcpTg, Ppara(+/-):HCVcpTg,...
Hepatitis C virus (HCV) is a major cause of chronic liver disease that frequently leads to steatosis, cirrhosis, and eventually hepatocellular carcinoma (HCC). HCV core protein not only component viral particles but also multifunctional because steatosis HCC are developed in gene-transgenic (CoreTg) mice. Proteasome activator PA28gamma/REGgamma regulates host proteins such as nuclear hormone receptors protein. Here we show knockout the PA28gamma gene induces accumulation nucleus hepatocytes...
ObjectivesThrombocytopenia is sometimes observed during linezolid therapy. Here, we aimed to investigate the factors affecting linezolid-induced thrombocytopenia.
Fatty liver disease (FLD) including non-alcoholic fatty (NAFLD), a rapidly emerging and widely recognized today, is regarded as hepatic manifestation of metabolic syndrome. Helicobacter pylori, one the most common pathogens worldwide, has been reported to be associated with syndrome, but whether there direct association FLD yet unclear. The aim this study was clarify NAFLD causative background factors pylori infection.This cross-sectional Japanese adults who received medical checkups at...
Abstract The accurate and prompt diagnosis of SARS-CoV-2 infection is required for the control treatment coronavirus disease 2019 (COVID-19). In this study, we aimed to investigate time courses anti-severe acute corona respiratory syndrome 2 (SARS-CoV-2) IgM IgG titers evaluate sensitivity specificity such tests according specific day after onset COVID-19 among a patient population in Japan. We measured sera from 105 subjects, including 26 symptomatic patients, using chemiluminescent...
Hepatic steatosis and hepatocellular carcinoma (HCC) are common serious features of hepatitis C virus (HCV) infection, the core protein has been shown to play distinct roles in pathogenesis. Here we report direct interaction HCV with retinoid X receptor α (RXRα), a transcriptional regulator that controls many aspects cell proliferation, differentiation, lipid metabolism. The binds DNA-binding domain RXRα, leading increase DNA binding RXRα its responsive element. In addition, is activated...
ABSTRACT Hepatitis C virus (HCV) core protein plays an important role in the formation of viral nucleocapsid and a regulatory involved hepatocarcinogenesis. In this study, we have identified proteasome activator PA28γ (11S regulator γ) as HCV binding by using yeast two-hybrid system. This interaction was demonstrated not only cell culture but also livers transgenic mice. These findings are extended to human infection observation liver specimens from patient with chronic infection. Neither...
The hepatitis C virus (HCV) core protein is a component of nucleocapsids and pathogenic factor for C. Several epidemiological experimental studies have suggested that HCV infection associated with insulin resistance, leading to type 2 diabetes. We previously reported gene-transgenic (PA28gamma(+/+)CoreTg) mice develop marked resistance the degraded in nucleus through PA28gamma-dependent pathway. In this study, we examined whether PA28gamma required core-induced vivo. lacking gene...
Bacillus cereus is one of the pathogens causing nosocomial bloodstream infections (BSIs). However, few reports have documented antimicrobial susceptibility and clinical characteristics BSI importance empirical therapy. The aim this study was to investigate B. isolates from patients with analyze impact appropriate therapy on outcome BSI.All adult cases bacteremia between April 2003 March 2012 in a teaching hospital Tokyo, Japan were reviewed retrospectively. Clinical data collected patients'...
Difficult-to-treat infections caused by rapidly growing mycobacteria (RGM) are increasingly observed in clinical settings. However, studies on antimicrobial susceptibilities and effective treatments against RGM Japan limited. We conducted susceptibility testing of potential agents, including tigecycline tebipenem, RGM. Clinical isolates were collected from a university hospital between December 2010 August 2013. They identified using matrix-assisted laser desorption/ionization time-of-flight...
ABSTRACT Although KPC enzymes are most common among carbapenemases produced by Enterobacter cloacae complex globally, the epidemiology varies from one country to another. While previous studies have suggested that IMP in Japan, detailed analysis has been scarce thus far. Here, we carried out a molecular epidemiological study and plasmid of IMP-1-producing E. isolates collected three hospitals central Tokyo using whole-genome sequencing. Seventy-one were classified into several sequence types...
Abstract Aim Sarcopenia has a high prevalence and can be an adverse predictor in patients with chronic liver diseases (CLDs). We sought to assess the of sarcopenia its prognostic significance CLDs at multiple centers Japan. Methods In this retrospective study, we collated data 1624 (976 men). The diagnosis was determined by assessment criteria Japan Society Hepatology. Predictors mortality were identified using univariate multivariate analyses. Results Muscle weakness skeletal muscle loss...
A loop-mediated isothermal amplification (LAMP) assay for the rapid detection of Mycoplasma pneumoniae was developed and evaluated. The specifically amplified only M. sequences, no cross-reactivity observed other species or respiratory bacterial species. limit this found to be 2 x 10(2) copies, corresponding 2-20 colour changing units in 1 h, as a real-time turbidimeter electrophoretic analysis. accuracy LAMP reaction confirmed by restriction endonuclease analysis well direct sequencing...