A5101896608- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- T-cell and Retrovirus Studies
- T-cell and B-cell Immunology
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- RNA Research and Splicing
- Inflammation biomarkers and pathways
- RNA and protein synthesis mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Animal Disease Management and Epidemiology
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Bone Metabolism and Diseases
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- RNA regulation and disease
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
Kissei Pharmaceutical (Japan)
2025
Kanazawa University Hospital
2012-2025
The University of Tokyo
2015-2024
Advanced Institute of Industrial Technology
2023
Tokyo University of Science
1999-2020
Kanazawa University
1968-2016
Japan Science and Technology Agency
2010-2014
Takara (Japan)
2012
Intensive Care Society
2012
Nagasaki University
2005
CD4(+) T regulatory cells (T(regs)), which express the Foxp3 transcription factor, play a critical role in maintenance of immune homeostasis. Here, we show that mice, T(regs) were most abundant colonic mucosa. The spore-forming component indigenous intestinal microbiota, particularly clusters IV and XIVa genus Clostridium, promoted T(reg) cell accumulation. Colonization mice by defined mix Clostridium strains provided an environment rich transforming growth factor-β affected Foxp3(+) number...
A critical function of tumor suppressor p53 is the induction apoptosis in cells exposed to noxious stresses. We report a previously unidentified pro-apoptotic gene, Noxa . Expression primary mouse x-ray irradiation was dependent on p53. encodes Bcl-2 homology 3 (BH3)–only member family proteins; this contains BH3 region but not other BH domains. When ectopically expressed, underwent motif–dependent localization mitochondria and interacted with anti-apoptotic members, resulting activation...
The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK activated through phosphorylation by (MAPKK), which first MAPKK (MAPKKK). A genetic selection based on in yeast was used to identify mouse (TAK1) distinct from other members of the MAPKKK family. TAK1 shown participate regulation transcription transforming growth factor-beta (TGF-beta). Furthermore, activity stimulated response TGF-beta and...
Interleukin-6 (IL-6/BSF-2/IFNβ 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, known particularly for its role in immune response acute phase reactions. A complementary DNA encoding human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists 468 amino acids, including signal peptide ∼19 acids domain ∼90 similar to immunoglobulin (Ig) superfamily. cytoplasmic ∼82 lacks tyrosine/kinase domain, unlike other factor receptors.
In mice lacking the interleukin-2 receptor beta chain (IL-2R beta), T cells were shown to be spontaneously activated, resulting in exhaustive differentiation of B into plasma and appearance high serum concentrations immunoglobulins G1 E as well autoantibodies that cause hemolytic anemia. Marked infiltrative granulocytopoiesis was also apparent, animals died after about 12 weeks. Depletion CD4+ mutant rescued without reversion granulocyte abnormalities. did not proliferate response polyclonal...
Production of nitric oxide (NO) by macrophages is important for the killing intracellular infectious agents. Interferon (IFN)- γ and lipopolysaccharide stimulate NO production transcriptionally up-regulating inducible synthase (iNOS). Macrophages from mice with a targeted disruption IFN regulatory factor-1 (IRF-1) gene (IRF-1 -/- mice) produced little or no synthesized barely detectable iNOS messenger RNA in response to stimulation. Two adjacent IRF-1 elements were identified promoter....