A5049979270- Nuclear physics research studies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Quantum Chromodynamics and Particle Interactions
- Immune Response and Inflammation
- Reproductive Biology and Fertility
- NF-κB Signaling Pathways
- Pluripotent Stem Cells Research
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Quantum chaos and dynamical systems
- Renal and related cancers
- RNA Research and Splicing
- Atomic and Subatomic Physics Research
- Lymphatic System and Diseases
- Reproductive System and Pregnancy
- Neutrino Physics Research
- Cold Atom Physics and Bose-Einstein Condensates
- Congenital heart defects research
- interferon and immune responses
- Advanced Chemical Physics Studies
- Cell Adhesion Molecules Research
- Inflammatory mediators and NSAID effects
The University of Tokyo
2013-2023
Tokyo University of Science
2004-2022
Systems Biology Institute
2009-2022
Kansai University
2002-2020
Japan Aerospace Exploration Agency
2015-2019
University of Zagreb
2004-2009
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2003-2009
RIKEN Center for Integrative Medical Sciences
2009
Expression Génétique Microbienne
2003
Osaka University
1982-2002
Signal transducer and activator of transcription (STAT) proteins have been shown to mediate biological actions in response cytokines. Stat3, a member the STAT family, is activated by variety cytokines, including interleukin 6 family leptin, granulocyte colony-stimulating factor, epidermal growth factor. To address function we generated mice deficient Stat3 gene targeting. No viable Stat3-deficient could be obtained from heterozygote intercross. Analysis embryos at several gestation times...
Allergic asthma is caused by the aberrant expansion in lung of T helper cells that produce type 2 (T H 2) cytokines and characterized infiltration eosinophils bronchial hyperreactivity. This disease often triggered mast activated immunoglobulin E (IgE)–mediated allergic challenge. Activated release various chemical mediators, including prostaglandin D (PGD ), whose role has now been investigated generation mice deficient PGD receptor (DP). Sensitization aerosol challenge homozygous mutant...
gp130 is a ubiquitously expressed signal-transducing receptor component shared by interleukin 6, 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic and cardiotrophin 1. To investigate physiological roles of to examine pathological consequences lack gp130, mice deficient for have been prepared. Embryos homozygous the mutation progressively die between 12.5 days postcoitum term. On 16.5 later, they show hypoplastic ventricular myocardium without septal trabecular defect. The...
Mice lacking the gene encoding receptor for prostaglandin F 2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in estrous cycle, ovulation, fertilization, or implantation, they did not respond exogenous oxytocin because of lack induction (a proposed triggering event parturition), and show decline serum progesterone concentrations that precedes parturition. Ovariectomy day 19 pregnancy restored permitted...
Abstract Stat3, a member of STAT, is activated by variety cytokines such as IL-6 family cytokines, granulocyte CSF, epidermal growth factor, and leptin. A recent study with mice genetically deficient in the Stat3 gene has revealed its important role early embryogenesis. To assess function adult tissues, we disrupted specifically T cells conditional targeting using Cre-loxP system. In Stat3-deficient cells, IL-6-induced proliferation was severely impaired. did not enhance cell cycle...
Female mice lacking the gene encoding prostaglandin (PG) E 2 receptor subtype EP (EP −/− ) become pregnant and deliver their pups at term, but with a much reduced litter size. A decrease in ovulation number fertilization rate were observed females without difference of uterus to support implantation wild-type embryos. Treatment gonadotropins induced mRNA expression cumulus cells ovarian follicles mice. The immature cumuli oophori from expanded vitro response both follicle-stimulating hormone...
Several members of the chemokine receptor family have been shown to function in association with CD4 permit human immunodeficiency virus type 1 (HIV-1) entry and infection. The CXC CXCR4/fusin is a for pre–B cell growth stimulating factor (PBSF)/stromal cell–derived (SDF-1) serves as coreceptor T line–tropic HIV-1 strains. Thus, development CXCR4 antagonists or agonists may be useful treatment T22 ([Tyr5,12,Lys7]-polyphemusin II) synthesized peptide that consists 18 amino acid residues an...
Mammalian sulfoglycolipids comprise two major members, sulfatide (HSO3-3-galactosylceramide) and seminolipid (HSO3-3-monogalactosylalkylacylglycerol). Sulfatide is a lipid component of the myelin sheath serves as epitope for well known oligodendrocyte-marker antibody O4. Seminolipid synthesized in spermatocytes maintained subsequent germ cell stages. Both can be vitro by using isolated cerebroside sulfotransferase. To investigate physiological role to determine whether are biosynthesized...
Pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group chemokines that initially identified as bone marrow stromal and pre-B-cell stimulatory factor. Although most are thought to be inducible inflammatory mediators, PBSF/SDF-1 essential for perinatal viability, B lymphopoiesis, myelopoiesis, cardiac ventricular septal formation, it has chemotactic activities on resting lymphocytes monocytes. In this paper, we have isolated cDNA encodes...
Flk-1 (human counterpart, KDR) tyrosine kinase, which is one of the two VEGF receptors, crucial for vascular development. Recently, we showed that, among residues KDR, 1175 (Y1175, corresponding to Y1173 in murine Flk-1) and Y1214 (Y1212 are autophosphorylated response VEGF, that Y1175 important VEGF-dependent phospholipase Cγ/PKC/mitogen-activated protein kinase activation leading DNA synthesis cultured endothelial cells. However, importance these Flk-1/KDR vivo not yet known. To examine...