A5020771892- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Clusterin in disease pathology
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- S100 Proteins and Annexins
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Gastrointestinal Tumor Research and Treatment
- Immunotherapy and Immune Responses
- Ovarian cancer diagnosis and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
Iwate Medical University
2021-2025
National Institute of Biomedical Innovation, Health and Nutrition
2013-2025
Wakayama Medical University
2011-2025
Kōchi University
2016-2024
Clinical Emergency Hospital Bucharest
2022
Kochi Medical School Hospital
2016-2021
University of Kochi
2021
Osaka International Cancer Institute
1994-2018
Osaka University
2004-2015
Kanazawa University
2014
IL-17-producing T helper cells (Th17) have been recently identified as a previously undescribed subset of cells. Here, we demonstrate that aryl hydrocarbon receptor (Ahr) has an important regulatory function in the commitment Th17 Ahr was robustly induced under Th17-polarizing conditions. Ahr-deficient naïve showed considerable loss ability to differentiate into when by TGF-β plus IL-6. We were able interacts with Stat1 and Stat5, which negatively regulate development. Whereas activation...
Toll-like receptor (TLR) signals perform a crucial role in innate immune responses to pathogens. In this study, we found that the aryl hydrocarbon (Ahr) negatively regulates inflammatory mediated by lipopolysaccharide (LPS) macrophages. Ahr was induced macrophages stimulated LPS, but not transforming growth factor (TGF)-β plus interleukin (IL)-6, which can induce naive T cells. The production of IL-6 and tumor necrosis (TNF)-α LPS significantly elevated Ahr-deficient compared with wild-type...
CD4(+) T cells producing IL-17 [T helper (Th)17], as distinct from Th1 or Th2 cells, have recently been shown to be associated with autoimmunity, but it is not entirely clear how Th17 are generated naïve cells. We demonstrate here that IL-6, TNF-alpha IL-1beta, can, in combination TGF-beta, induce cell generation and inhibit TGF-beta-induced Foxp3 expression. Moreover, conditioned medium lipopolysaccharide-stimulated bone marrow-derived dendritic (DCCM) can production Interestingly, was...
The development of Th17 cells is a key event in the pathogenesis experimental autoimmune encephalomyelitis (EAE), murine model human multiple sclerosis (MS). Previous studies have demonstrated that an IL-6-dependent pathway involved differentiation from naïve CD4-positive T vitro. However, role IL-6 vivo EAE has remained unclear. In present study, we found blockade by treatment with anti-IL-6 receptor monoclonal antibody (anti-IL-6R mAb) inhibited and induction myelin oligodendrocyte...
Growth, differentiation, and programmed cell death (apoptosis) are mainly controlled by cytokines. The Janus kinase-signal transducers activators of transcription (JAK-STAT) signal pathway is an important component cytokine signaling. We have previously shown that STAT3 induces a molecule designated as SSI-1, which inhibits functions. To clarify the physiological roles SSI-1 in vivo, we generated, here, mice lacking SSI-1. These SSI-1-/- displayed growth retardation died within 3 weeks after...
Cytokine-inducible protein SSI-1 [signal transducers and activators of transcription (STAT)-induced STAT inhibitor 1, also referred to as SOCS-1 (suppressor cytokine signaling 1) or JAB (Janus kinase-binding protein)] negatively regulates receptor by inhibition JAK kinases. The SSI family proteins includes eight members that are structurally characterized an SH2 domain a C-terminal conserved region we have called the SC-motif. In this study, investigated roles these domains in function...
To investigate the mechanism of interleukin-6 (IL-6) blockade in autoimmune arthritis, by comparing effect anti-IL-6 receptor (anti-IL-6R) monoclonal antibody (mAb) treatment with soluble tumor necrosis factor (sTNFR)-Fc fusion protein on T helper cell differentiation collagen-induced arthritis (CIA).DBA/1 mice were immunized type II collagen (CII) to induce and left untreated or treated anti-IL-6R mAb TNFR-Fc. cytokine expression during development these analyzed.Immunization CII...
The development of helper T (Th) cell subsets, which secrete distinct cytokines, plays an important role in determining the type immune response. IL-4-mediated Janus kinase–signal transducer and activator transcription signaling pathway is crucial for mediating Th2 development. Notably, this selectively impaired Th1 cells, although molecular basis impairment remains unclear. We show here that during differentiation a reduction association kinase 1 with IL-4 receptor (IL-4R) correlated...
BackgroundReliable biomarkers for monitoring disease activity have not been clinically established in ulcerative colitis (UC). This study aimed to investigate whether levels of serum leucine-rich alpha-2 glycoprotein (LRG), identified recently as a potential marker Crohn's and rheumatoid arthritis, correlate with UC.
<h3>Objective</h3> To identify a novel serum biomarker of disease activity in inflammatory autoimmune disorders. <h3>Methods</h3> Sera obtained from rheumatoid arthritis (RA) patients before and after anti-TNF therapy were analysed by iTRAQ (isobaric tags for relative absolute quantitation) quantitative proteomic analysis further validated ELISA. <h3>Results</h3> Of 326 proteins identified analysis, increased levels leucine-rich α-2 glycoprotein (LRG) was RA therapy. Serum LRG concentrations...
Suppressor of cytokine signaling-1 (SOCS-1) is one the negative-feedback regulators Janus kinase (JAK)–signal transducer and activator transcription (STAT) signaling. We previously showed that SOCS-1 participates in LPS signaling, but it not entirely clear yet how suppresses In this study, we demonstrate selectively inhibits LPS-induced IL-6 production through regulation JAK–STAT TNF-α, granulocyte colony-stimulating factor, IFN-β, other cytokines. found directly activated Jak2 Stat5,...
Human herpesvirus-6B (HHV-6B) is a T lymphotropic β-herpesvirus that clearly distinct from human herpesvirus-6A (HHV-6A) according to molecular biological features. The International Committee on Taxonomy of Viruses recently classified HHV-6B as separate species. primary infection causes exanthem subitum and sometimes associated with severe encephalopathy. More than 90% the general population infected during childhood, virus remains throughout life latent infection. reactivation encephalitis...
IL-6 is a proinflammatory cytokine and its overproduction implicated in variety of inflammatory disorders. Recent vitro analyses suggest that key determines the balance between Foxp3(+) regulatory T cells (Tregs) Th17 cells. However, it remains unclear whether excessive production vivo alters development function Tregs. In this study, we analyzed transgenic (Tg) mice which serum levels are constitutively elevated. Interestingly, Tg mice, whereas peripheral lymphoid organs were enlarged,...
Summary The aim of this study was to determine whether CD4 + IL‐17A Th17 cells infiltrate vitiligo skin and investigate the proinflammatory cytokines related cell influence melanocyte enzymatic activity fate. An immunohistochemical analysis showed infiltration in 21 23 samples addition CD8 on reticular dermis. vitro that expression MITF downstream genes downregulated melanocytes by treatment with interleukin (IL)‐17A, IL‐1β, IL‐6, tumor necrosis factor (TNF)‐α. Treatment these also induced...
Although several noninvasive and easily accessible biomarkers for inflammatory bowel disease [IBD] are available, their sensitivity specificity not adequate to be used as single markers do overrule the need endoscopic evaluation. We previously reported that serum leucine-rich alpha-2 glycoprotein [LRG] was a novel biomarker rheumatoid arthritis IBD. herein investigated whether LRG could indicate activity in patients with ulcerative colitis [UC].Serum concentrations were determined by...
Cutaneous wound repair is a highly ordered and well-coordinated process involving various cell lineages many molecular effectors. Cell-matrix interactions through integrin molecules provide key signals important for repair. Periostin matricellular protein that may during tissue development remodelling by interacting with several molecules, via the phosphatidylinositol 3-kinase/Akt MAP kinase pathways. In this study, we examined role of periostin in cutaneous using periostin-deficient mice...