A5072330134- Inflammatory mediators and NSAID effects
- Semiconductor materials and devices
- Health Systems, Economic Evaluations, Quality of Life
- Estrogen and related hormone effects
- Glass properties and applications
- Pelvic floor disorders treatments
- Luminescence Properties of Advanced Materials
- Copper Interconnects and Reliability
- Silicon Carbide Semiconductor Technologies
- Electromagnetic Compatibility and Noise Suppression
- Diabetes Treatment and Management
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Cancer Treatment and Pharmacology
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Eicosanoids and Hypertension Pharmacology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Laser-Plasma Interactions and Diagnostics
- Amyotrophic Lateral Sclerosis Research
- Nuclear Physics and Applications
- NF-κB Signaling Pathways
- Prion Diseases and Protein Misfolding
- Atrial Fibrillation Management and Outcomes
- Lymphoma Diagnosis and Treatment
Hitachi (Japan)
2013-2023
Shibuya (Japan)
2023
Kyoto City Hospital
2015-2020
Osaka Dental University
2018-2020
Kitano Hospital
2020
Nara Medical University Hospital
2020
Wake Forest University
2017
Forest Institute
2017
John Wiley & Sons (United States)
2017
Bristol-Myers Squibb (Germany)
2017
Allergic asthma is caused by the aberrant expansion in lung of T helper cells that produce type 2 (T H 2) cytokines and characterized infiltration eosinophils bronchial hyperreactivity. This disease often triggered mast activated immunoglobulin E (IgE)–mediated allergic challenge. Activated release various chemical mediators, including prostaglandin D (PGD ), whose role has now been investigated generation mice deficient PGD receptor (DP). Sensitization aerosol challenge homozygous mutant...
Mice lacking the gene encoding receptor for prostaglandin F 2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in estrous cycle, ovulation, fertilization, or implantation, they did not respond exogenous oxytocin because of lack induction (a proposed triggering event parturition), and show decline serum progesterone concentrations that precedes parturition. Ovariectomy day 19 pregnancy restored permitted...
We used mice deficient in each of the eight types and subtypes prostanoid receptors examined roles prostanoids dextran sodium sulfate–induced (DSS-induced) colitis. Among receptor–deficient mice, only EP4-deficient not either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced marginal wild-type mice. This phenotype was mimicked by administration an EP4-selective antagonist (AE3-208). The EP4 deficiency impaired mucosal barrier function epithelial...
We used mice deficient in each of the eight types and subtypes prostanoid receptors examined roles prostanoids dextran sodium sulfate–induced (DSS-induced) colitis. Among receptor–deficient mice, only EP4-deficient not either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced marginal wild-type mice. This phenotype was mimicked by administration an EP4-selective antagonist (AE3-208). The EP4 deficiency impaired mucosal barrier function epithelial...
Nonsteroidal antiinflammatories are known to suppress incidence and progression of malignancies including colorectal cancers. However, the precise mechanism this action remains unknown. Using prostaglandin (PG) receptor knockout mice, we have evaluated a role PGs in tumor-associated angiogenesis tumor growth, identified PG receptors involved. Sarcoma-180 cells implanted wild-type (WT) mice formed with extensive angiogenesis, which was greatly suppressed by specific inhibitors for...
High fat intake is associated with mass gain through fatty acid activation of peroxisome proliferator-activated receptors δ and γ, which promote adipogenesis. We show herein that, compared to a combination specific agonists both or saturated, monounsaturated, ω-3 polyunsaturated acids, arachidonic (C20:4, ω-6) promoted substantially the differentiation clonal preadipocytes. This effect was blocked by cyclooxygenase inhibitors mimicked carbacyclin, suggesting role for prostacyclin receptor...
Prostaglandin (PG) I(2) and thromboxane (TX) A(2), the most common prostanoids in cardiovascular system, are produced abundantly during cardiac ischemia/reperfusion (I/R); their roles I/R injury, however, remain undetermined. We intended to clarify these of PGI(2) TXA(2) using mice lacking receptor, IP(-/-) mice, or TP(-/-) mice.The left anterior descending coronary artery was occluded for 1 hour then reperfused 24 hours. The size myocardial infarct significantly larger than that wild-type...
To investigate the significance of peroxynitrite-mediated oxidative damage in pathogenesis sporadic amyotrophic lateral sclerosis (SALS), concentrations 3-nitrotyrosine and tyrosine cerebrospinal fluid (CSF) patients with SALS were determined. The concentration 3-nitrotyrosine/ ratio approximately seven times those controls. Thus, present findings living provide vivo evidence for a possible role peroxynitrite, mediator stress, increased nitration residues SALS. Ann Neurol 1999;46:129–131
Abstract Purpose This study aimed to develop a Japanese value set for the EORTC QLU-C10D, multi-attribute utility measure derived from cancer-specific health-related quality-of-life (HRQL) questionnaire, QLQ-C30. The QLU-C10D contains ten HRQL dimensions: physical, role, social and emotional functioning, pain, fatigue, sleep, appetite, nausea, bowel problems. Methods Quota sampling of online panel was used achieve representativeness general population by sex age (≥ 18 years). valuation...
Abstract To investigate the possible role of oxidative RNA damage in pathogenesis Alzheimer's disease (AD), concentrations stress marker 8‐hydroxyguanosine (8‐OHG) were measured cerebrospinal fluid (CSF) and serum patients with AD control subjects. The concentration 8‐OHG CSF was approximately fivefold that controls ( P < 0.001). decreased significantly duration illness (r s = −0.48, 0.05) progression cognitive dysfunctions 0.67, 0.01). However, showed no correlation both patients. In...
The effects of docosapentaenoic acid (DPA) on platelet aggregation and arachidonic metabolism were studied in comparison to those eicosapentaenoic (EPA) docosahexaenoic (DHA). Collagen- or acid-stimulated was inhibited dose-dependently by n-3 fatty acids, among which DPA the most potent inhibitor. These acids U46619-induced but almost same extent. No effect thrombin-induced observed. Furthermore, these suppressed thromboxane A2 formation platelets exposed collagen thrombin, added. In...
Prostaglandin E2 (PGE2) exerts its actions via four subtypes of the PGE receptor, EP1–4. We show that mice deficient in EP1 exhibited significantly attenuated Th1 response contact hypersensitivity induced by dinitrofluorobenzene (DNFB). This phenotype was recapitulated wild-type administration an EP1-selective antagonist during sensitization phase, and adoptive transfer T cells from sensitized EP1−/− mice. Conversely, agonist facilitated differentiation naive vitro. Finally, CD11c+...
Cyclooxygenase (COX)‐2 is known to correlate with poor cancer prognosis and contribute tumor metastasis. However, the precise mechanism of this phenomenon remains unknown. We have previously reported that host stromal prostaglandin E 2 (PGE )–prostaglandin E2 receptor (EP)3 signaling appears critical for tumor‐associated angiogenesis growth. Here we tested whether EP3 has a role in Lewis lung carcinoma (LLC) cells were intravenously injected into WT mice treated COX‐2 inhibitor NS‐398. The...
There is scarce evidence comparing novel oral anticoagulants (NOACs) with warfarin in real-world settings Japan. This study compared the risk of bleeding events among patients non-valvular atrial fibrillation (NVAF) initiating treatment NOACs versus warfarin.A retrospective cohort was conducted using a de-identified electronic health record based database claims and Diagnosis Procedure Combination data from 275 consenting hospitals NVAF newly initiated on were eligible. Based first...
Abstract Donor-independent platelet concentrates for transfusion can be produced in vitro from induced pluripotent stem cells (iPSCs). However, culture at 37°C induces ectodomain shedding on platelets of glycoprotein Ibα (GPIbα), the von Willebrand factor receptor critical adhesive function and lifetime vivo, through temperature-dependent activation a disintegrin metalloproteinase 17 (ADAM17). The suppressed by using inhibitors panmetalloproteinases possibly upstream regulator p38...
We have developed a 3.3 kV ultra-high power density SiC module, which was realized by fulfilment with only SiC-MOSFETs. As countermeasure for bipolar degradation issues related to body diodes in the MOSFET structure, high throughput screening process has been introduced. In process, over 10000 chips of SiC-MOSFET were evaluated. The large amount data firstly reveals probability distribution phenomena and enables us study relationship defect densities state-of-the-art wafers. Furthermore,...