A5083485606- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Advanced Breast Cancer Therapies
- Spondyloarthritis Studies and Treatments
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Allergic Rhinitis and Sensitization
- CAR-T cell therapy research
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Cancer and Skin Lesions
- Lymphoma Diagnosis and Treatment
- Skin and Cellular Biology Research
- Sinusitis and nasal conditions
- Urticaria and Related Conditions
- Cancer-related Molecular Pathways
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- melanin and skin pigmentation
- Hepatitis C virus research
- Viral-associated cancers and disorders
- Nonmelanoma Skin Cancer Studies
- Hepatitis B Virus Studies
- Salivary Gland Tumors Diagnosis and Treatment
Tokyo Teishin Hospital
2011-2024
University of Yamanashi
2009-2024
Rockefeller University
2014-2023
University of Yamanashi Hospital
2010-2023
The University of Tokyo
2004-2018
Memorial Hospital of South Bend
1996-2018
Mitsui (Japan)
2017
Mitsui Memorial Hospital
1983-2006
Osaka University
2006
Tokyo Medical University
2004
Summary Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease characterized by the predominant infiltration of T cells, eosinophils macrophages in lesional skin. Recently, macrophage-derived chemokine (MDC)/CCL22, CC chemokine, was identified as selective chemoattractant for receptor 4 (CCR4)-expressing addition to thymus activation-regulated (TARC). We have previously reported that serum TARC levels correlate with severity AD. In this report, we investigated...
Abstract Objective . To investigate the characteristics of HLA‐B27 that render susceptibility to seronegative spondylarthropathies. Methods Serologic HLA class I typing Japanese patients with ankylosing spondylitis (AS), juvenile rheumatoid arthritis (JRA), and healthy controls, was performed. HLA‐B39 subtypes were determined by polymerase chain reaction‐sequence‐specific oligohy‐bridization. Results present in 40 48 AS (83%), only 1 210 controls (0.5%). Three 8 (37.5%) who negative for...
Primary cutaneous T-cell lymphomas (CTCL) are neoplastic disorders of skin-homing T cells. Affected skin areas show morphologic similarities with alterations in other T-cell-mediated dermatoses. Furthermore, as atopic dermatitis but contrast psoriasis, patients CTCL frequently afflicted by bacterial infections that support the survival lymphoma Our aim was to investigate mechanisms elevated susceptibility CTCL.Skin samples from CTCL, and were used illuminate antibacterial competence status...
Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease characterized by the predominant infiltration of T cells, eosinophils macrophages in lesional skin. Recently, eotaxin-2/CCL24 eotaxin-3/CCL26 were identified as CC chemokines that signal exclusively via CCR3 receptor have eosinophil-selective chemoattractant activity, does eotaxin/CCL11. We previously reported serum levels thymus activation-regulated chemokine (TARC)/CCL17 macrophage-derived (MDC)/CCL22 correlated...
Malignancy has been reported as a causative factor of cutaneous vasculitis, although only two retrospective epidemiological studies have analysed the association between Henoch-Schönlein purpura (HSP) and malignancy to date.To analyse adult HSP malignancy.We retrospectively reviewed medical records patients found 103 cases over past 20 years. Fifty-three (aged > or = 41 years) were categorized groups including 'with malignancy' 'without malignancy', so that we could differences clinical...
Abstract Background Prurigo nodularis (PN), a chronic inflammatory skin condition, adversely affects the quality of life affected individuals. Current treatment options for PN in Japan are limited. Objectives To evaluate optimal dose, efficacy and safety long-term with nemolizumab patients Japan. Methods In 16-week double-blind phase II/III study, aged ≥ 13 years were randomly assigned (1 : 1 1) to 30-mg, 60-mg or placebo groups, concomitant topical corticosteroids, every 4 weeks. The...
Psoriasis is a common skin disease characterized by hyperplastic regenerative epidermal growth and infiltration of immunocytes. The etiology psoriasis unknown, although several genetic cellular factors have been elucidated. To find new psoriasis-related genes, we cloned cDNAs that are differentially expressed between normal psoriatic skins. Among these clones, identified gene codes for member the type IV cytosolic phospholipase A2 (cPLA2) family. We refer to this as cPLA2δ. It encodes...
Abstract Vitiligo is an autoimmune skin disease with acquired depigmentation. Dietary habits may modulate the pathogenesis of vitiligo. We evaluated dietary in adult Japanese patients nonsegmental vitiligo, and compared their results those age‐ sex‐matched controls. also examined relationship between Area Scoring Index (VASI), or vitiligo on different anatomical sites. The intakes energy, nutrients, foods participants were analyzed using a brief‐type self‐administered diet history...
Primary liver cancers, which are generally hypervascular in nature, depend highly on blood supply. So far there few reports apoptosis of cancer cells upon deprivation serum-derived survival factors. The aim our study is to clarify molecular mechanisms by survive with the aid serum. In HepG2 cells, serum induced time-dependent increase number apoptotic was detected fragmentation genomic DNA and fluorescent nuclear staining. activity extracellular signal-regulated kinase (ERK) did not decrease...
ABSTRACT Capsule-forming Klebsiella pneumoniae K1 caused primary liver abscess in two household members of a family. The causative isolates had identical pulsed-field gel electrophoresis patterns and were determined to be sequence type 23. An additional member the family was found carry same strain without clinical manifestation.
Abstract Objective . To identify possible factors in the development of acute anterior uveitis (AUU) patients with ankylosing spondylitis (AS). Methods We investigated HLA antigens serologically, and HLA–DRB1 * 08 alleles by polymerase chain reaction–restriction fragment length polymorphism, 42 Japanese AS without AAU. Results Thirty‐six (85.7%) had HLA–B27. Thirteen (65%) 20 AAU HLA–DR8, whereas only 1 (4.5%) 22 DR8. The difference was statistically significant ( P corr < 0.001)....
Mesenteric vein thrombosis is generally difficult to diagnose and can be fatal. A case of extensive the mesenteric portal veins was diagnosed early successfully treated in a 26-year-old man with Down syndrome who admitted hospital because abdominal pain, severe nausea high fever. Ultrasonography revealed moderate ascites, there minimal flow (PV) on Doppler examination. Computed tomography (CT) showed remarkable thickening walls small intestine mesenteric, splenic veins. Because neither...
Abstract Constitutive activation of signal transducer and activator transcription 3 (STAT3) is common in many human murine cancer cells, its leads to cellular transformation. STAT3 pathway inhibitors have been reported suppress growth. To investigate the antitumor effects inhibiting STAT3-mediated signaling cascade microenvironment, using a molecular-targeting approach, we focused on gene associated with retinoid-IFN-induced mortality 19 (GRIM-19). GRIM-19 has interact physically inhibit...
<b><i>Background and Aims:</i></b> It remains unclear whether obesity increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C who achieved a sustained virological response (SVR) antiviral therapy. <b><i>Methods:</i></b> In this multicenter cohort study, we enrolled SVR interferon (IFN)-based therapy (IFN group) or direct-acting (DAA) (DAA between January 1, 1990, December 31, 2018. The underwent regular...
BackgroundAtopic dermatitis (AD) is a common chronic eczematous skin disease with severe pruritus. Several new therapeutic agents for AD such as dupilumab, an anti–IL-4Rα antibody, have been developed in recent years. We need to predict which agent the best choice each patient, but this remains difficult.ObjectiveOur aim was examine clinical background factors and baseline biomarkers that could achievement of improved outcomes patients treated dupilumab.MethodsA multicenter, prospective...