A5027554519- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
- Eosinophilic Disorders and Syndromes
- Cutaneous lymphoproliferative disorders research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Cancer and Skin Lesions
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Vitamin K Research Studies
- Hemophilia Treatment and Research
- Receptor Mechanisms and Signaling
- T-cell and B-cell Immunology
- Skin and Cellular Biology Research
- Nonmelanoma Skin Cancer Studies
Hiroshima University
2016-2025
Hiroshima City Asa Citizens Hospital
2020-2025
Citizens Specialty Hospitals
2022-2024
Hiroshima University Hospital
2013-2024
Hiroshima Prefectural Hospital
2021-2022
City Hospital
2022
Japan Science and Technology Agency
2022
Niigata University
2018
Kyoto University
2009
Hiroshima Institute of Technology
2002-2007
Most urticarias are induced by vasoactive mediators such as histamine released from mast cells. Although cells activated allergens through cross-linking of cell-surface-bound IgE, this mechanism does not appear to explain most cases chronic urticaria, which, when allergic, infectious, drug-induced, or physical causes cannot be identified, classified idiopathic.
This update and revision of the international guideline for urticaria was developed following methods recommended by Cochrane Grading Recommendations Assessment, Development Evaluation (GRADE) working group. It is a joint initiative Dermatology Section European Academy Allergology Clinical Immunology (EAACI), Global Allergy Asthma Network (GA²LEN) its Urticaria Angioedema Centers Reference Excellence (UCAREs ACAREs), Forum (EDF; EuroGuiDerm), Asia Pacific Association Allergy, with...
Abstract Hereditary Angioedema ( HAE ) is a rare and disabling disease. Early diagnosis appropriate therapy are essential. This update revision of the global guideline for provides up‐to‐date consensus recommendations management . In development this guideline, an international expert panel reviewed existing evidence developed 20 that were discussed, finalized consented during conference in June 2016 Vienna. The final version incorporates contributions board reviewers endorsing societies....
Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis effective therapy are critical. This revision update of the global WAO/EAACI guideline on management HAE provides up-to-date guidance HAE. For this guideline, an international panel experts reviewed existing evidence, developed 28 recommendations, established consensus by online DELPHI process. The goal these recommendations to help physicians their patients in making rational decisions with deficient C1...
Significant unmet need exists for long-term treatment of moderate to severe atopic dermatitis (AD).To assess the safety and efficacy dupilumab in patients with AD.This ongoing, multicenter, open-label extension study (NCT01949311) evaluated adults who had previously participated phase 1 through 3 clinical trials AD. This analysis examined given 300 mg weekly up 76 weeks at data cutoff (April 2016). Safety was primary outcome; also evaluated.Of 1491 enrolled (1042.9 patient-years), 92.9% were...
Summary Circulating histamine releasing factor(s) have been demonstrated previously in chronic urticaria by an immediate weal‐and‐flare response to intradermal autologous serum injection. We studied 25 patients vivo skin testing with sera and vitro release assay using mixed leukocytes of healthy donors, define the nature functional properties factor(s). Twenty showed a weal (mean ± s.e.m., 37.3±6.8 mm 3 ). Weal formation was confined ultrafiltered fractions > 100 kD nine patients. There...
Abstract Atopic dermatitis (AD) is a chronic relapsing eczematous skin disease characterized by pruritus and inflammation accompanied cutaneous physiological dysfunction (dry barrier‐disrupted skin). Most of the patients have atopic diathesis. A standard guideline for management (diagnosis, severity classification therapy) AD has been established. In our guideline, necessity dermatological training emphasized in order to assure diagnostic skill enable evaluation AD. The definitive diagnosis...
Summary Background Food‐dependent exercise‐induced anaphylaxis (FDEIA) is an allergic reaction characteristically induced by intense exercise combined with the ingestion of causative food. Recent reports have shown that aspirin intake a contributing factor in some patients FDEIA. Wheat known to be most frequent food, and IgE‐binding epitopes major wheat allergen (ω‐5 gliadin) wheat‐dependent (WDEIA) already been clarified. However, mechanism eliciting symptom WDEIA remains not fully...
The variability in measurements of complex permittivities tumor tissues between multiple samples could be attributed to the volume fraction cancer cells excised tissue. By use a digital photomicrograph image and hematoxylin-eosin staining, it was found that malignant tissue not fully occupied by cells, but were distributed locally stroma depending on growth cancer. results showed had correlation measured conductivity dielectric constant frequency range from 1 GHz 6 GHz. It introduces method...
The evaluation of disease severity and activity chronic urticaria (CU) is essential for the adequate treatment patients. However, there no reliable biomarker such evaluations. Recently, markers blood coagulation fibrinolysis have been revealed to be elevated in severe cases CU. In this article, we studied coagulation/fibrinolysis inflammation their relationship patients with CU.Plasma fibrin degradation products (FDP), d-dimer serum C-reactive protein (CRP) were measured assessment skin...
Abstract Background GA² LEN , the Global Allergy and Asthma European Network, has recently launched a program for development, interaction, accreditation of centers reference excellence in special areas allergy embedded its overall quality management excellence. The first area chosen is urticaria. Urticaria common debilitating condition can be challenge both patients treating physicians, especially when chronic. Centers urticaria ( UCARE s) help to improve hard‐to‐treat conditions such as...
In light of the remarkable progress recently achieved in our understanding angioedema, American Academy Allergy, Asthma and Immunology, College European Association Allergy Clinical World Organization have joined together to promote communication about diagnosis management angioedema on a global scale. Within framework this collaboration, termed International Collaboration Asthma, Immunology (iCAALL), series Consensus (ICON) documents are being developed serve as resource support physicians...
Abstract Atopic dermatitis ( AD ) is a disease characterized by relapsing eczema with pruritus as primary lesion. The current strategies to treat in Japan from the perspective of evidence‐based medicine consist three measures: (i) use topical corticosteroids and tacrolimus ointment main treatment for inflammation; (ii) application emollients cutaneous barrier dysfunction; (iii) avoidance apparent exacerbating factors, psychological counseling advice about daily life. guidelines present...
Management of moderate-to-severe atopic dermatitis (AD) commonly requires long-term treatment. The aim this study was to report the safety and efficacy dupilumab treatment for up 3 years in adults with AD. This ongoing, multicenter, open-label extension (LIBERTY AD OLE; NCT01949311) assessed previously enrolled trials. Patients received 300 mg weekly 148 weeks. primary outcome safety. Of 2677 patients treated, 347 reached week 148. Mean self-reported drug compliance 98.2%. Safety data were...