A5004722620- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Health Systems, Economic Evaluations, Quality of Life
- Acne and Rosacea Treatments and Effects
- Hidradenitis Suppurativa and Treatments
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Colorectal and Anal Carcinomas
- T-cell and B-cell Immunology
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Vitamin D Research Studies
- Advancements in Transdermal Drug Delivery
- Drug-Induced Adverse Reactions
- Systemic Sclerosis and Related Diseases
- melanin and skin pigmentation
- Spondyloarthritis Studies and Treatments
- Mast cells and histamine
- Skin Protection and Aging
- Microscopic Colitis
- Cutaneous Melanoma Detection and Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Debrecen
2016-2025
UiT The Arctic University of Norway
2024
Research Network (United States)
2024
Hungarian Research Network
2024
University of Szeged
2019
Karolinska Institutet
2016
Asociación Colombiana de Dermatología y Cirugía Dermatológica
2012
University Dermatology
2007
Advanced Dermatology
2002
Central Institute of Mental Health
2002
This update and revision of the international guideline for urticaria was developed following methods recommended by Cochrane Grading Recommendations Assessment, Development Evaluation (GRADE) working group. It is a joint initiative Dermatology Section European Academy Allergology Clinical Immunology (EAACI), Global Allergy Asthma Network (GA²LEN) its Urticaria Angioedema Centers Reference Excellence (UCAREs ACAREs), Forum (EDF; EuroGuiDerm), Asia Pacific Association Allergy, with...
Abstract Introduction This second part of the S2k guidelines is an update 2015 S1 European guidelines. Objective These aim to provide accepted decision aid for selection, implementation and assessment appropriate sufficient therapy patients with hidradenitis suppurativa/acne inversa (HS). Methods The chapters have been selected after a Delphi procedure among experts/authors. Certain passages adopted without changes from previous version. Potential treatment complications are not included,...
Sebaceous glands drive acne, however, their role in other inflammatory skin diseases remains unclear. To shed light on potential contribution to disease development, we investigated the spatial transcriptome of sebaceous psoriasis and atopic dermatitis patients across lesional non-lesional human samples. Both expressed genes encoding key proteins for lipid metabolism transport such as ALOX15B, APOC1, FABP7, FADS1/2, FASN, PPARG , RARRES1. Also, inflammation-related SAA1 was identified a...
Abstract Background Chronic inflammatory diseases including bowel disease (IBD; Crohn's and ulcerative colitis), psoriasis rheumatoid arthritis (RA) afflict millions of people worldwide, but their pathogenesis is still not well understood. It also known if distinct changes in gene expression characterize these patterns can discriminate between diseased control patients and/or stratify the disease. The main focus our work was identification novel markers that overlap among 3 or them from each...
Transient receptor potential (TRP) ion channels were first characterized on neurons, where they are classically implicated in sensory functions; however, research recent decades has shown that many of these also expressed nonneuronal cell types. Emerging findings have highlighted the role TRP skin, been to be important numerous cutaneous functions. Of particular interest is TRPV3, which was described keratinocytes. Its functional importance supported when its gain-of-function mutation linked...
As lipids are known to regulate macrophage functions, it is reasonable suppose that a sebocyte-macrophage axis mediated by sebum may exist.To investigate if sebocytes could contribute the differentiation, polarization and function of macrophages with their secreted lipids.Oil Red O lipid staining Raman spectroscopy were used assess dermal content penetration. Immunohistochemistry was analyse subsets. Human peripheral blood monocytes differentiated in presence either supernatant from human...
Rosacea is a common chronic inflammation of sebaceous gland-rich facial skin characterized by severe dryness, elevated pH, transepidermal water loss, and decreased hydration levels. Until now, there has been no thorough molecular analysis permeability barrier alterations in the patients with rosacea. Thus, we aimed to investigate papulopustular rosacea samples compared healthy skin, using RNA sequencing (n = 8). Pathway analyses Cytoscape ClueGO revealed 15 significantly enriched pathways...
Trichophyton indotineae is associated with difficult-to-treat, often extensive dermatophytosis and resistance to the commonly used antifungal agents. Successful therapy necessitates higher than usual doses of systemic for prolonged periods. The spread this species has gained much attention lately, as several European other Western hemisphere countries have recently reported their first respective cases or increasing numbers them. Until recently, was not described in Hungary. Here, we report...
Regulatory T cells (Tregs) have an essential role in tolerance and immune regulation. However, few controversial data been published to date on the number of these atopic dermatitis (AD).To investigate CD4+CD25+FOXP3+ Tregs interleukin 10-producing regulatory type 1 (Tr1) patients with AD.Peripheral blood skin biopsy samples from atopy patch test (APT)-positive acute- chronic-phase AD were investigated. Immunohistochemistry was applied identify skin, while flow cytometry used detect...
'Not relevant' responses (NRRs) on the Dermatology Life Quality Index (DLQI) may occur in up to 40% of patients with psoriasis. As these are scored as item questionnaire having no impact patients' lives at all, it is more difficult for fulfil DLQI > 10 criterion required by clinical guidelines become candidates systemic treatment including biologics.We propose a new scoring system that corrects bias NRR option and test its construct validity sample psoriasis.Data from 242 (104 whom marked...
Lipoxygenases (LOX) and cyclooxygenase (COX) are the main enzymes for PUFA metabolism to highly bio-active prostaglandins, leukotrienes, thromboxanes, lipoxins, resolvins protectins. LOX COX pathways important regulation of pro-inflammatory or pro-resolving metabolite synthesis various inflammatory diseases such as atopic dermatitis (AD). In this study, we determined PUFAs metabolites in serum well affected non-affected skin samples from AD patients dermal expression enzymes, binding...
Hidradenitis suppurativa (HS) is a chronic, inflammatory disease of the apocrine gland-rich (AGR) skin region. The initial steps development are not fully understood, despite intense investigations into immune alterations in lesional HS skin.We aimed to systematically investigate molecules involved three stages pathogenesis, including healthy AGR, non-lesional and skin, with parallel application multiple mRNA protein-based methods.Immune cell counts (T cells, dendritic macrophages),...
Abstract Background Generalized pustular psoriasis (GPP) is a rare, inflammatory skin disease characterized by widespread eruption of sterile pustules with or without systemic symptoms. Objectives This study aimed to describe the demographics patients GPP in Central and Eastern Europe (CEE), present clinical characteristics individual flares explore current treatment landscape. Methods Patient were collected at times last observation previous treatment. Characteristics patient's (most...
Filaggrin (FLG) deficiency is a well-known predisposing factor for the development of atopic dermatitis (AD). Decreased FLG expression can be result haploinsufficiency or severe inflammation, which cause acquired alterations. mutations are related to several clinical and laboratory parameters AD; however, some recent data seem contradict these associations.Our aim was determine biochemical connected ones also associated with alterations due skin symptoms in patients AD.We introduced novel...
The immunological barrier of the healthy skin is considered to be unified on whole body surface-however, recent indirect findings have challenged this dogma since microbial and chemical milieu (e.g., sebum, sweat, pH) exhibit remarkable differences topographically distinct areas. Therefore, in present study, we performed transcriptomic subsequent pathway analyses assess between sebaceous gland rich (SGR) poor (SGP) regions. Here, provide first evidence that different regions a characteristic...
Abstract Background Numerous generic, skin‐ and disease‐specific health‐related quality of life (HRQoL) measures are available for patients with hidradenitis suppurativa (HS). Yet, robust psychometric evidence is lacking in many aspects these outcome measures. Objectives We sought to determine convergent known‐groups validity multiple generic skin‐specific HRQoL identify predictors impaired HS. Methods Between 2017 2019, a multicentre cross‐sectional study was carried out involving 200...
Coronavirus disease 2019 (COVID-19) has a high mortality in elderly patients with pre-existing cardiovascular diseases. The cellular receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the angiotensin-converting enzyme (ACE2), thereby implicating link between diseases and SARS-CoV-2 susceptibility. Aortic stenosis (AS) represents chronic inflammatory state complications elderly, prime condition for COVID-19 mortality. circulating ACE2 levels were measured 111 AS...