A5036164605- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Medicine and Dermatology Studies History
- Nail Diseases and Treatments
- Contact Dermatitis and Allergies
- Metabolism and Genetic Disorders
- Food Allergy and Anaphylaxis Research
- Adrenal Hormones and Disorders
- Psoriasis: Treatment and Pathogenesis
- Glycogen Storage Diseases and Myoclonus
- Pharmacological Effects of Natural Compounds
- Cutaneous lymphoproliferative disorders research
- Corneal surgery and disorders
- Pain Mechanisms and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Adverse Reactions
- Liver Disease Diagnosis and Treatment
- Oral and gingival health research
- Eosinophilic Disorders and Syndromes
- Eosinophilic Esophagitis
- Lysosomal Storage Disorders Research
- Carbohydrate Chemistry and Synthesis
University Hospital Münster
2016-2025
University of Münster
2014-2024
Universitätsmedizin Greifswald
2015-2024
Klinik für Schlafmedizin
2008-2024
University of Copenhagen
2021-2024
University of North Carolina at Chapel Hill
2012-2022
Toscana Life Sciences
2021
Pfizer (United Kingdom)
2021
Giessen School of Theology
2020
John Wiley & Sons (United States)
2019
Chronic itch is a common and distressing symptom that arises from variety of skin conditions systemic diseases. Despite this, there no clinically based classification pruritic diseases to assist in the diagnosis cost-effective medical care patients with pruritus. The proposed focuses on clinical signs distinguishes between without primary or secondary lesions. Three groups are proposed: pruritus diseased (inflamed) (group I), non-diseased (non-inflamed) II), presenting severe chronic scratch...
Abstract The existing evidence for treatment of atopic eczema (atopic dermatitis, AE) is evaluated using the national standard Appraisal Guidelines Research and Evaluation. consensus process consisted a nominal group DELPHI procedure. Management AE must consider individual symptomatic variability disease. Basic therapy focused on hydrating topical treatment, avoidance specific unspecific provocation factors. Anti‐inflammatory based glucocorticosteroids calcineurin inhibitors (TCI) used...
The most commonly used tool for self-report of pruritus intensity is the visual analogue scale (VAS). Similar tools are numerical rating (NRS) and verbal (VRS). In present study, initiated by International Forum Study Itch assessing reliability these tools, 471 randomly selected patients with chronic itch (200 males, 271 females, mean age 58.44 years) recorded their on VAS (100-mm line), NRS (0-10) VRS (four-point) scales. Re-test was analysed in a subgroup 250 after one hour. Statistical...
The aim of this study was to evaluate the visual analogue scale (VAS) as a method pruritus assessment. A total 310 subjects with pruritic dermatoses (148 Caucasian and 162 Asian subjects) were recruited. patients assessed intensity using horizontal vertical VAS, numeric rating (NRS) verbal (VRS). All scales showed very good reproducibility (intraclass coefficient (ICC) > 0.8). No significant differences found between VAS (5.3 ± 2.9 vs. 5.3 3.0 points, p = 0.34). Using NRS, rated their...
The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non-selective cation channel that recently has been shown in human keratinocytes vitro and vivo. However, description of VR1 localization other cutaneous compartments particular nerve fibers still lacking. We therefore investigated immunoreactivity as well mRNA protein expression series (n = 26) normal 7), diseased 13) [prurigo nodularis (PN) 10), generalized pruritus 1), mastocytosis 2)], capsaicin-treated skin 6)....
Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person the general population has suffered from chronic pruritus at least once lifetime with 12-month incidence of 7%. In patient populations its frequency much higher depending on underlying cause, ranging around 25% haemodialysis patients to 100% skin diseases such as urticaria and atopic dermatitis (AD). may be result dermatological or non-dermatological disease. Especially non-diseased it caused by...
Chronic pruritus is a global clinical problem with high impact on the quality of life and lack specific therapies. It an excruciating frequent symptom e.g. uncurable renal, liver skin diseases which often does not respond to conventional treatment antihistamines. Therefore antipruritic therapies target physiological mechanisms need be developed. Substance P (SP) major mediator pruritus. As it binds neurokinin receptor 1 (NKR1), we evaluated if application NKR1 antagonist would significantly...
Elke WEISShAAr1, Jacek C. SzEpIEToWSkI2, Ulf DArSoW3, Laurent MISEry4, Joanna WALLENgrEN5, Thomas METTANg6, Uwe gIELEr7, Torello LoTTI8, Julien LAMbErT9, peter MAISEL10, Markus STrEIT11, Malcolm W. grEAVES12, Andrew CArMIChAEL13, Erwin TSChAChLEr14, Johannes rINg3 and Sonja STaNDEr15 1Department of Clinical Social Medicine, Environmental Occupational Dermatology, Ruprecht-Karls-University Heidelberg, Germany, 2Department Venereology Allergology, Wroclaw Medical University, Poland,...
Prurigo nodularis is a chronic pruritic skin disease with multiple nodular lesions. Nemolizumab monoclonal antibody targeting the interleukin-31 receptor, which involved in pathogenesis of prurigo nodularis.
Abstract Background The term prurigo has been used for many decades in dermatology without clear definition, and currently terminology of is inconsistent confusing. Especially, itch‐related remains unexplored regarding the epidemiology, clinical profile, natural course, underlying causes, available treatments economic burden, although burdensome difficult to treat. Objective To address these issues, multicentre European Prurigo Project (EPP) was designed increase knowledge on chronic (CPG)....
Sensitive skin is a frequent complaint in the general population, patients, and among subjects suffering from itch. The International Forum for Study of Itch (IFSI) decided to initiate special interest group (SIG) on sensitive skin. Using Delphi method, was defined as "A syndrome by occurrence unpleasant sensations (stinging, burning, pain, pruritus, tingling sensations) response stimuli that normally should not provoke such sensations. These cannot be explained lesions attributable any...
Prurigo nodularis (PN) is a chronic inflammatory skin disease with intensely pruritic nodules. The LIBERTY-PN PRIME and PRIME2 phase 3 trials enrolled adults PN ≥20 nodules severe itch uncontrolled topical therapies. Dupilumab, fully human monoclonal antibody, blocks the shared receptor component for interleukin (IL)-4 IL-13. Patients were randomized 1:1 to 300 mg dupilumab or placebo subcutaneously every 2 weeks 24 weeks. primary endpoint was pruritus improvement, measured by proportion of...
Prurigo nodularis is a chronic, debilitating, and severely pruritic neuroimmunologic skin disease. Nemolizumab, an interleukin-31 receptor alpha antagonist, down-regulates key pathways in the pathogenesis of prurigo nodularis. Download PDF Research Summary. In this phase 3, double-blind, multicenter, randomized trial, we assigned adults with moderate-to-severe to receive initial 60-mg dose nemolizumab followed by subcutaneous injections 30 mg or 60 (depending on baseline weight) every 4...