A5086993961- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Skin Protection and Aging
- Allergic Rhinitis and Sensitization
- Nonmelanoma Skin Cancer Studies
- Asthma and respiratory diseases
- Cancer and Skin Lesions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cutaneous lymphoproliferative disorders research
- Vitamin D Research Studies
- Dermatological and Skeletal Disorders
- Pharmaceutical studies and practices
- Contact Dermatitis and Allergies
- Dermatologic Treatments and Research
- Cutaneous Melanoma Detection and Management
- Hedgehog Signaling Pathway Studies
- Food Allergy and Anaphylaxis Research
- Skin Diseases and Diabetes
- Nail Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Genetic and rare skin diseases.
- Biosimilars and Bioanalytical Methods
- Acne and Rosacea Treatments and Effects
Medical University of Lodz
2016-2025
Centrum Medyczne iMed24
2023
Wojewódzki Szpital Specjalistyczny we Wrocławiu
2014
Centralny Szpital Kliniczny
2012
Ajou University
2009
Vanderbilt-Ingram Cancer Center
2009
Melanoma Institute Australia
2009
Dana-Farber Cancer Institute
2009
Massachusetts General Hospital
2009
Medical University of Warsaw
2006
Prurigo nodularis is a chronic pruritic skin disease with multiple nodular lesions. Nemolizumab monoclonal antibody targeting the interleukin-31 receptor, which involved in pathogenesis of prurigo nodularis.
Abstract Non-melanoma skin cancers (NMSCs) are the most common malignancies diagnosed in Caucasian populations. Basal cell carcinoma (BCC) is frequent cancer, followed by squamous (SCC). Unfortunately, European cancer registries do not record individual types of NMSC. To evaluate incidence primary BCCs and SCCs regarding age, sex, tumour site subtype to determine trends epidemiology both cancers. Retrospective analysis treated across seven sites Poland from 1999 2019. We recorded 13,913...
BackgroundABP 501 is a biosimilar of adalimumab.ObjectiveWe sought to compare the efficacy and safety ABP with adalimumab.MethodsThis 52-week, double-blind study randomized patients moderate severe psoriasis or adalimumab. At week 16, those 50% more improvement in Psoriasis Area Severity Index score from baseline on continued same treatment, whereas adalimumab-treated were rerandomized adalimumab 501. Clinical similarity percent 16 (primary end point) was established if point estimate...
The data that support the findings of this study are available from corresponding author upon reasonable request. Appendix S1: Supplementary Information S2. S3. S4. S5. S6. Please note: publisher is not responsible for content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to article.
Sunlight contains ultraviolet (UV)A and UVB radiation. is essential for vitamin D synthesis but the main cause of sunburn skin cancer. Sunscreen use advocated to reduce sun's adverse effects may compromise status. To assess ability two intervention sunscreens inhibit during a week‐long sun holiday. The impact on status was studied 1‐week holiday in Tenerife (28° N). Comparisons were made between formulations, each with protection factor (SPF) 15. UVA‐protection (PF) low one case high other....
In 2019, a group of experts published the first European guidelines for management congenital ichthyoses after multidisciplinary expert meeting held in 2016. An update these and literature search was planned every 5 years, given clinical, molecular therapeutic advances, including use biologic therapies. We present here updated that have been developed by reorganized international systematic review recent literature, discussions, consensus reached at an conference June 2023. The provide...
Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim our study was to evaluate whether monotherapy chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-alpha group consisted 25 patients mild or moderate activity age- sex-matched healthy control subjects. In the cytokine were measured just before three months after starting treatment at...
Alopecia areata (AA) and vitiligo are both common skin diseases of autoimmune origin. Both alopecia have shown to be affected by oxidative stress. The present work is aimed at evaluating comparing the serum proinflammatory cytokine levels in AA nonsegmental (NSV). A cross-sectional study was conducted 33 patients with AA, 30 NSV, healthy controls. Serum interferon γ (IFN- ), interleukin- (IL-) 1 β , IL-6 were determined quantitatively ELISA method. Our analysis identified a signature stress...
Biologic treatments have been studied mainly in patients with a long-term history of psoriasis and previous treatment failures.The purpose this primary analysis the STEPIn study is to determine whether early intervention secukinumab new-onset moderate severe plaque superior standard care narrow band ultraviolet B (nb-UVB) phototherapy.The randomized, open-label, multicentre investigate 52 weeks 300 mg administered subcutaneously versus nb-UVB phototherapy (≤12 months) (NCT03020199). The...
Scientific communications indicate the disturbed expression of neuropeptides in skin and serum psoriasis vulgaris (PsV) patients. Narrow-band ultraviolet radiation (NB-UVB) is one systemic therapies PsV. The aim study was to evaluate influence NB-UVB therapy on substance P (SP), calcitonin gene-related peptide (CGRP), brain-derived neurotrophic factor (BDNF), corticotropin-releasing (CRF) interleukin-31 (IL-31) concentrations PsV 59 psoriatic patients with mean PASI (psoriasis area severity...
Antimalarials are widely used for the treatment of systemic lupus erythematosus. However, their mechanisms action have not been fully elucidated. Literature data indicate that matrix metalloproteinases may play a role in immune response and tissue damage occur autoimmune skin diseases. The aim this study was to determine effect 3 months chloroquine on serum levels MMP-9 TIMP-1 patients with group consisted 25 erythematosus sex- age-matched healthy volunteers. Before drug administration, were...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Ciążyńska M, Narbutt J, Woźniacka A, Lesiak A. Trends in basal cell carcinoma incidence rates: a 16-year retrospective study of population central Poland. Advances Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2018;35(1):47-52. doi:10.5114/ada.2018.73164. APA Ciążyńska, M., Narbutt, J., Woźniacka, A., & Lesiak, (2018). Alergologii, 35(1), 47-52. https://doi.org/10.5114/ada.2018.73164 Chicago...
Basal cell carcinomas (BCCs) are the most common malignancies in white people. The incidence varies depending on region of world, with highest rate 1% to 2% per year noted Australia. It is estimated that BCC increases by 5% annually. An increasing line changes living style and exposure various environmental factors.To present factors may influence development BCCs. ultraviolet radiation alone connection immunosuppression, smoking, occupational factors, as well arsenic ionizing exposure, was...
Background: Although filaggrin mutations are presently believed to play a key role in the development of atopic dermatitis (AD), obviously also immunological factors involved acquired immune response important for allergic inflammation. Objective: To assess frequency FLG and polymorphisms 590 C/T IL-4 gene, -1082A/G IL-10 gene -1055C/T IL-13 patients with AD their correlations between severity asthma. Methods: R501X 2282del4 IL-4, were assayed 163 Polish origin. Results: In AD, prevalence...
Regulatory T cells (Tregs), toll-like receptors (TLRs) and interleukin-17 (IL-17) play important role in inflammatory diseases; however, their relevance atopic dermatitis (AD) pathogenesis is not clear. The aim of study was to evaluate the number circulating Tregs peripheral blood mononuclear (PBMC) expressing TLR2 TLR4 patients with AD. PBMC CD4+/CD25(high) + were isolated from whole 32 AD 36 healthy volunteers. Expression CD4+CD25+, IL 17+ assessed flow cytometry. In patients, percentage...
Background: Vitamin D and folate are influenced by ultraviolet radiation (UVR), both implicated in skin carcinogenesis. Polymorphisms the genes involved metabolism of these two compounds may alter risk basal cell carcinoma (BCC). Objective: To assess frequency four polymorphisms gene encoding vitamin receptor (VDR) (FokI, BsmI, TaqI ApaI) methylenetetrahydrofolate reductase (MTHFR) (677C/T 1286A/C) 142 patients Polish origin with BCC same number controls. The expression VDR MTHFR proteins...