Mark Gompels
A5014109607- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Hemophilia Treatment and Research
- Adolescent Sexual and Reproductive Health
- Vitamin K Research Studies
- Blood disorders and treatments
- Urticaria and Related Conditions
- Blood groups and transfusion
- Drug-Induced Adverse Reactions
- Blood Coagulation and Thrombosis Mechanisms
- Lymphoma Diagnosis and Treatment
- Food Allergy and Anaphylaxis Research
- Tuberculosis Research and Epidemiology
- Autoimmune Bullous Skin Diseases
- Viral-associated cancers and disorders
- Pharmacological Effects and Toxicity Studies
- Parvovirus B19 Infection Studies
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
North Bristol NHS Trust
2016-2025
Southmead Hospital
2016-2025
National Health Service
2016-2024
Ionis Pharmaceuticals (United States)
2024
Barzilai Medical Center
2024
Jagiellonian University
2024
Amsterdam University Medical Centers
2022
University of Amsterdam
2022
Chelsea and Westminster Hospital
2011-2017
The Royal Free Hospital
2017
The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared available heterosexual couples. aim second phase PARTNER study (PARTNER2) was to provide precise estimates partnerships.The a prospective observational done at 75 sites 14 European countries. first (PARTNER1; Sept 15, 2010, May 31, 2014) recruited and followed up both (HIV-positive ART)...
The objective of this study is to estimate life expectancies HIV-positive patients conditional on response antiretroviral therapy (ART).Patients aged more than 20 years who started ART during 2000-2010 (excluding IDU) in HIV clinics contributing the UK CHIC Study were followed for mortality until 2012. We determined latest CD4 cell count and viral load before each 1-5 ART. For duration ART, tables based estimated rates by sex, age, suppression (HIV-1 RNA <400 copies/ml), used expected age at...
<b>Objectives </b>To estimate life expectancy for people with HIV undergoing treatment compared in the general population and to assess impact on of late treatment, defined as CD4 count <200 cells/mm<sup>3</sup> at start antiretroviral therapy. <b>Design </b>Cohort study. <b>Setting </b>Outpatient clinics throughout United Kingdom. <b>Population </b>Adult patients from UK Collaborative Cohort (UK CHIC) Study ≤350 therapy 1996-2008. <b>Main outcome measures </b>Life exact age 20 (the...
Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis effective therapy are critical. This revision update of the global WAO/EAACI guideline on management HAE provides up-to-date guidance HAE. For this guideline, an international panel experts reviewed existing evidence, developed 28 recommendations, established consensus by online DELPHI process. The goal these recommendations to help physicians their patients in making rational decisions with deficient C1...
Hereditary angioedema (C1 inhibitor deficiency, HAE) is associated with intermittent swellings which are disabling and may be fatal. Effective treatments available these most useful when given early in the course of swelling. The requirement to attend a medical facility for parenteral treatment results delays. Home therapy offers possibility earlier better symptom control, enabling patients live more healthy, productive lives. This paper examines evidence patient-controlled home acute...
Hereditary angioedema is a life-threatening illness caused by mutations in the gene encoding C1 inhibitor (also called esterase inhibitor) that lead to overactivation of kallikrein-bradykinin cascade. BCX7353 potent oral small-molecule plasma kallikrein with pharmacokinetic and pharmacodynamic profile may help prevent attacks.In this international, three-part, dose-ranging, placebo-controlled trial, we evaluated four doses (62.5 mg, 125 250 350 mg once daily) for prevention attacks over...
Vaccination prevents severe morbidity and mortality from COVID-19 in the general population. The immunogenicity efficacy of SARS-CoV-2 vaccines patients with antibody deficiency is poorly understood.
Hereditary angioedema is a rare disorder characterized by episodic, potentially life-threatening swelling caused kallikrein-kinin dysregulation. Long-term prophylaxis can stabilize this system. Donidalorsen, an antisense oligonucleotide, specifically reduces prekallikrein expression.
An alternative pathway of Trp metabolism involves the conversion to kynurenine by indoleamine-2,3-dioxygenase, which leads synthesis neurotoxin, quinolinic acid. This study explores relationship indoleamine-2,3-dioxygenase activity with stages HIV infection. Sera from 206 HIV-positive and 72 seronegative subjects were analyzed for kynurenine. The kynurenine-to-Trp (KT) ratio was calculated. mean KT controls 36.6 +/- 10.9, median 34.9. upper limit ratio, defined as + 2 SD, 58.4. Patients...
To compare the efficacy, safety, and impact on lipid fractions of switching from a ritonavir-boosted protease inhibitor (PI/r) to dolutegravir (DTG) regimen.
BackgroundStandard-of-care antiretroviral therapy (ART) uses a combination of drugs deemed essential to minimise treatment failure and drug resistance. Protease inhibitors are potent, with high genetic barrier resistance, have potential use as monotherapy after viral load suppression is achieved treatment. We aimed assess clinical risks benefits protease inhibitor in long-term use: particular, the effect on resistance future options.MethodsIn this pragmatic, parallel-group, randomised,...
To compare rates of all-cause, liver-related, and AIDS-related mortality among individuals who are HIV-monoinfected with those coinfected HIV hepatitis B (HBV) and/or C (HCV) viruses.An ongoing observational cohort study collating routinely collected clinical data on HIV-positive attending for care at treatment centres throughout the United Kingdom.Individuals were included if they had been seen from 2004 onwards tested HBV HCV. Crude (all cause, liver related, AIDS related) calculated HIV,...
This is the second report of United Kingdom Primary Immunodeficiency (UKPID) registry. The registry will be a decade old in 2018 and, as August 2017, had recruited 4758 patients encompassing 97% immunology centres within Kingdom. represents doubling recruitment into since we reported on 2229 included our first 2013. Minimum PID prevalence currently 5·90/100 000 and an average incidence between 1980 2000 7·6 cases per 100 UK live births. Data are presented frequency diseases recorded, disease...
SUMMARY We have undertaken a retrospective study of antibody deficient patients, with and without lymphoma, assessed the ability specific polymerase chain reaction (PCR) primers to determine if detection clonal lymphocyte populations correlates clinical immunohistochemical diagnosis lymphoma. identified 158 cases deficiency presenting during past 20 years. Paraffin-embedded biopsy specimens or slides were available for analysis in cohort 34 patients. Of these 29 had common variable...
Aim: To determine the diagnostic efficiency of assays routinely used in investigation hereditary angiooedema.Methods: Over a four year period, 1144 samples were received for analysis from 907 patients suspected C1 inhibitor deficiency.Analyses performed C4 and (functional immunochemical).Notes reviewed retrospectively on with low serological indicators to diagnosis.Results: These are first data indicate sensitivity, specificity, predictive values most frequently screen deficiency.A...
Objective: To identify a definition of presentation after clinical or immunological disease progression that will reliably an individual at high risk mortality over the first 3 months HIV diagnosis and can be adopted as basis for comparing time regions. Design: An observational cohort study. Methods: Individuals seen UK Collaborative Cohort study clinic from 1996 to 2006 were identified. Two (CD4 cell count < 200 cells/μl CD4 <50 cells/μl) two (AIDS severe/moderate AIDS) criteria with...
BackgroundThe length of time that people with HIV on antiretroviral therapy (ART) viral load suppression will be able to continue before developing rebound is unknown. We aimed investigate the rate first in have achieved initial ART, determine factors associated rebound, and use these estimates predict long-term durability suppression.MethodsThe UK Collaborative Cohort (UK CHIC) Study an ongoing multicentre cohort study brings together a standardised format data attending clinics around UK....
GA2LEN, the Global Allergy and Asthma European Network, HAE international (HAEi), global umbrella organization for world's hereditary angioedema (HAE) patient groups, have launched their joint ACARE (Angioedema Center of Reference Excellence) program, within GA2LEN's center reference excellence (CORE) initiative. Angioedema is a common, heterogeneous, often debilitating chronic condition frequently challenge physicians affected patients, especially patients suffering from recurrent attacks....