Sarah Fidler
A5067056877- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Impact and Responses
- Adolescent and Pediatric Healthcare
- SARS-CoV-2 and COVID-19 Research
- Sex work and related issues
- Hepatitis C virus research
- Tuberculosis Research and Epidemiology
- vaccines and immunoinformatics approaches
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Renal Transplantation Outcomes and Treatments
- Vaccine Coverage and Hesitancy
- Organ Donation and Transplantation
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Global Maternal and Child Health
- Syphilis Diagnosis and Treatment
Imperial College London
2016-2025
NIHR Imperial Biomedical Research Centre
2019-2025
Imperial College Healthcare NHS Trust
2016-2025
St. Mary's Hospital
2005-2024
St Mary's Hospital
2005-2024
Hospice UK
2023
National Institute for Health Research
2019-2023
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2019-2023
St Mary's Hospital
2006-2022
Johns Hopkins University
2019-2022
The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared available heterosexual couples. aim second phase PARTNER study (PARTNER2) was to provide precise estimates partnerships.The a prospective observational done at 75 sites 14 European countries. first (PARTNER1; Sept 15, 2010, May 31, 2014) recruited and followed up both (HIV-positive ART)...
A universal testing and treatment strategy is a potential approach to reduce the incidence of human immunodeficiency virus (HIV) infection, yet previous trial results are inconsistent.
In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim identifying individuals in whom ART might induce period viraemic control on stopping therapy, we hypothesised that quantification pool primary infection (PHI) would predict clinical progression and replication following ART. We measured DNA highly characterised randomised with PHI. explored associations between immunological virological markers...
The overall purpose of these guidelines is to provide guidance on best clinical practice in the treatment and management adults with HIV infection antiretroviral therapy (ART). scope includes: (i) initiation ART those previously naïve therapy; (ii)support patients treatment; (iii) experiencing virological failure; (iv) recommendations specific patient populations where other factors need be taken into consideration. are aimed at professionals directly involved responsible for care community...
Effective interventions to reduce HIV incidence in sub-Saharan Africa are urgently needed. Mathematical modelling and the Prevention Trials Network (HPTN) 052 trial results suggest that universal testing combined with immediate antiretroviral treatment (ART) should substantially may eliminate as a public health problem. We describe rationale design of evaluate this hypothesis.A rigorously-designed (UTT) is needed because: i) it unknown whether these can be delivered scale adequate uptake;...
Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as low dose vaccine against COVID-19.
Introduction Scope and purpose Methodology Guideline development process Patient involvement GRADE Good practice points Dissemination implementation updates date of next review Treatment aims Resource use Implications for research References Recommendations auditable outcomes (GRADE) in decision making (Section 3) When to start 4) What 5) Supporting patients on therapy 6) Managing virological failure 7) Antiretroviral therapies specific populations 8) Summary measures decision-making...
Abstract Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state ‘post-treatment control’ (PTC) some patients, whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding processes that maintain viral persistence. Here we show immunological biomarkers can predict time to rebound after stopping by analysing data from randomized study primary incorporating treatment interruption (TI) 48 (the...
Risk-reduction counselling is a standard preventive intervention, but behaviour change difficult to sustain over the duration of HIV infection. However, primary infection (PHI) highly infectious and plays key role in transmission - especially through dense sexual networks short term, so even transient risk reduction can mitigate its high infectivity. Targeting behaviour-change interventions at recently infected individuals may be effective, particularly higher groups. We explored potential...
The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 inhibitory molecules are up-regulated in infection associate with immune dysfunction. We evaluated participants (n = 122) recruited the SPARTAC randomised clinical trial determine whether exhaustion markers PD-1, Lag-3 Tim-3 were associated activation disease progression. Expression of Tim-3, CD38 on cells from closest pre-therapy time-point seroconversion was measured flow...
Achieving HIV epidemic control globally will require new strategies to accelerate reductions in incidence and mortality. Universal test treat (UTT) was evaluated four randomized population-based trials (BCPP/Ya Tsie, HPTN 071/PopART, SEARCH, ANRS 12249/TasP) conducted sub-Saharan Africa (SSA) during expanded antiretroviral treatment (ART) eligibility by World Health Organization guidelines the UNAIDS 90-90-90 campaign.
The overall purpose of these guidelines is to provide guidance on best clinical practice in the treatment and management adults with HIV infection antiretroviral therapy (ART). scope includes: (i) initiation ART those previously naïve therapy; (ii) support people living (PLWH) treatment; (iii) individuals experiencing virological failure; (iv) recommendations specific populations where other factors need be taken into consideration. are aimed at professionals directly involved responsible...
The Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets require that, by 2020, 90% of those living with HIV know their status, known HIV-positive individuals receive sustained antiretroviral therapy (ART), and ART have durable viral suppression. HPTN 071 (PopART) trial is measuring the impact a universal testing treatment intervention population-level incidence in 21 urban communities Zambia South Africa. We report observational data from four to assess progress towards...