Deenan Pillay
A5017146733- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Impact and Responses
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- COVID-19 epidemiological studies
- Respiratory viral infections research
- Global Maternal and Child Health
- Poverty, Education, and Child Welfare
- Sex work and related issues
- Parvovirus B19 Infection Studies
- Hepatitis B Virus Studies
- Tuberculosis Research and Epidemiology
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 detection and testing
- Data-Driven Disease Surveillance
- Food Security and Health in Diverse Populations
- COVID-19 diagnosis using AI
- Genomics and Phylogenetic Studies
- Global Public Health Policies and Epidemiology
- Biosensors and Analytical Detection
University College London
2014-2024
Africa Health Research Institute
2016-2024
University of Malaya
2023
Institute for Medical Research
2023
Mortimer Market Centre
2022
Hospital Universitari Germans Trias i Pujol
2022
IrsiCaixa
2022
Institute of Infection and Immunity
2000-2021
University of KwaZulu-Natal
2018-2021
European Bioinformatics Institute
2020
Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines provide feedback on the success prevention programs. To accurately compare rates across geographic regions times, World Health Organization has recommended adoption a consensus genotypic definition resistance. In January 2007, we outlined criteria for developing list mutations drug-resistance surveillance compiled 80 RT protease meeting these (surveillance mutations;...
Resistance to antiretroviral drugs remains an important limitation successful human immunodeficiency virus type 1 (HIV-1) therapy. testing can improve treatment outcomes for infected individuals. The availability of new from various classes, standardization resistance assays, and the development viral tropism tests necessitate guidelines testing. International AIDS Society-USA convened a panel physicians scientists with expertise in drug-resistant HIV-1, drug management, patient care review...
SummaryBackgroundEmergence of variants with specific mutations in key epitopes the spike protein SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use monoclonal antibodies. We aimed describe emergence B.1.1.7 variant concern (VOC), including virological characteristics clinical severity contemporaneous patients without variant.MethodsIn this cohort study, samples positive for on PCR that were collected from Nov 9, 2020, acutely admitted one two hospitals or before Dec...
Objectives To estimate the impact of COVID-19 pandemic on cancer care services and overall (direct indirect) excess deaths in people with cancer. Methods We employed near real-time weekly data to determine adverse effect services. also used these data, together national death registrations until June 2020 model deaths, background (pre-COVID-19) mortality, Background mortality risks for 24 cancers without COVID-19-relevant comorbidities were obtained from population-based primary cohort...
<h2>Summary</h2><h3>Background</h3> Antiretroviral therapy (ART) is crucial for controlling HIV-1 infection through wide-scale treatment as prevention and pre-exposure prophylaxis (PrEP). Potent tenofovir disoproxil fumarate-containing regimens are increasingly used to treat prevent HIV, although few data exist frequency risk factors of acquired drug resistance in regions hardest hit by the HIV pandemic. We aimed do a global assessment after virological failure with first-line...
Contemporary antiretroviral therapies (ART) and management strategies have diminished both human immunodeficiency virus (HIV) treatment failure the acquired resistance to drugs in resource-rich regions, but transmission of drug-resistant viruses has not similarly decreased. In low- middle-income ART roll-out improved outcomes, resulted increasing transmitted resistances. Our objective was review methods detect it, provide updated recommendations for testing monitoring drug HIV-infected...
Background Sexually transmitted infections (STIs) and bacterial vaginosis (BV) are associated with increased transmission of HIV, poor reproductive sexual health. The burden STIs/BV among young people is unknown in many high HIV prevalence settings. We conducted an acceptability, feasibility, study home-based sampling for men women aged 15–24 years old a health demographic surveillance site (HDSS) rural KwaZulu-Natal, South Africa. Methods findings A total 1,342 people, stratified by age...
Background The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded regions of the world where diverse non-subtype-B viruses predominate. Methods Findings To assess impact subtype on distribution mutations in protease reverse transcriptase, a binomial response model using explanatory variables was used analyze large compiled dataset sequences. Non-subtype-B sequences from 3,686 persons with...
Objective To examine whether the level of primary resistance to HIV drugs is increasing in United Kingdom.