Catherine Houlihan
A5085847806- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- Poxvirus research and outbreaks
- SARS-CoV-2 detection and testing
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- Disaster Response and Management
- COVID-19 and Mental Health
- Infection Control and Ventilation
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Cervical Cancer and HPV Research
- Viral gastroenteritis research and epidemiology
- COVID-19 and healthcare impacts
- Global Security and Public Health
- Data-Driven Disease Surveillance
- Respiratory viral infections research
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Infectious Encephalopathies and Encephalitis
- Mosquito-borne diseases and control
University College London Hospitals NHS Foundation Trust
2020-2025
University College London
2016-2025
University College Hospital
2017-2025
UK Health Security Agency
2021-2024
National Hospital for Neurology and Neurosurgery
2020-2024
Royal London Hospital
2016-2023
Hospital for Tropical Diseases
2016-2023
Salisbury NHS Foundation Trust
2023
Great Ormond Street Hospital
2021-2023
Salisbury District Hospital
2023
Cases of human monkeypox are rarely seen outside west and central Africa. There few data regarding viral kinetics or the duration shedding no licensed treatments. Two oral drugs, brincidofovir tecovirimat, have been approved for treatment smallpox demonstrated efficacy against in animals. Our aim was to describe longitudinal clinical course a high-income setting, coupled with dynamics, any adverse events related novel antiviral therapies.
Abstract Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 order discuss begin understand presentations patients suspected COVID-19-related disorders. Detailed paraclinical were collected from cases...
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected humoral immunity. spike glycoprotein (S)-reactive were detectable using a flow cytometry-based method SARS-CoV-2-uninfected individuals and particularly prevalent children adolescents. They predominantly the immunoglobulin G (IgG) class targeted S2 subunit. By contrast, infection induced higher titers S-reactive IgG...
SummaryBackgroundEmergence of variants with specific mutations in key epitopes the spike protein SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use monoclonal antibodies. We aimed describe emergence B.1.1.7 variant concern (VOC), including virological characteristics clinical severity contemporaneous patients without variant.MethodsIn this cohort study, samples positive for on PCR that were collected from Nov 9, 2020, acutely admitted one two hospitals or before Dec...
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the viral entry protein, spike. Because new SARS-CoV-2 variants are emerging rapidly, as exemplified B.1.1.7, B.1.351, and P.1 lineages, it critical to understand whether antibody responses induced infection with original virus or current remain effective. In this study, we evaluate neutralization of a series mutated...
Coronavirus disease 2019 (COVID-19) can cause deadly healthcare-associated outbreaks. In a major London teaching hospital, 66 of 435 (15%) COVID-19 inpatient cases between 2 March and 12 April 2020 were definitely or probably hospital-acquired, through varied transmission routes. The case fatality was 36%. Nosocomial infection rates fell following comprehensive prevention control measures.
Most reported cases of human monkeypox occur in Central and West Africa, where the causing virus is endemic. We describe identification public health response to an imported case African from Nigeria United Kingdom (UK) May 2021. Secondary transmission index occurred within family another adult a toddler. Concurrent COVID-19-related control measures upon arrival at hospital, facilitated detection limited number potential contacts.
Abstract Background Routine asymptomatic testing using RT-PCR of people who interact with vulnerable populations, such as medical staff in hospitals or care workers homes, has been employed to help prevent outbreaks among populations. Although the peak sensitivity can be high, probability detecting an infection will vary throughout course infection. The effectiveness routine therefore depend on frequency and how PCR detection varies over time. Methods We fitted a Bayesian statistical model...
Abstract Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis children have been reported worldwide, including 278 the UK 1 . Here we report an investigation 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination genomic, transcriptomic, proteomic immunohistochemical methods. We detected high levels adeno-associated virus 2 (AAV2) DNA liver, blood, plasma or stool from 27 28 cases....
The scale of the 2022 global mpox (formerly known as monkeypox) outbreak has been unprecedented. In less than 6 months, non-endemic countries have reported more 67 000 cases a disease that had previously rare outside Africa. Mortality but hospital admission relatively common. We aimed to describe clinical and laboratory characteristics outcomes individuals admitted with associated complications, including tecovirimat recipients.
This article evaluates the Hlabisa HIV treatment and Care Programme in South Africa. The goal of this program is to promote prevention practices as part services with ultimate curbing epidemic. A cohort study monitored success integrated system impact on communities. It includes a tracking checkpoints children evaluations. concluded that properly placed location where population needs variety complex approach treatment. However more research needed determine whether maternal health ART TB...
BackgroundThe frequency of asymptomatic infection with Ebola virus is unclear: previous estimates vary and there no standard test. Asymptomatic could contribute to population immunity, reducing spread. If people are infectious it explain re-emergences disease (EVD) without known contact.MethodsWe validated a new oral fluid anti-glycoprotein IgG capture assay among survivors from Kerry Town Treatment Centre controls communities unaffected by EVD in Sierra Leone. We then assessed the...
Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) alpha variant (B.1.1.7) is associated with higher transmissibility than wild-type virus, becoming the dominant in England by January 2021. We aimed to describe severity of terms pathway disease from testing positive hospital admission and death. Methods With approval NHS England, we linked individual-level data primary care SARS-CoV-2 community testing, admission, Office for National Statistics all-cause...
Abstract Several related human coronaviruses (HCoVs) are endemic in the population, causing mild respiratory infections 1 . Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), etiologic agent of disease 2019 (COVID-19), is a recent zoonotic infection that has quickly reached pandemic proportions 2,3 Zoonotic introduction novel thought to occur absence pre-existing immunity target population. Using diverse assays for detection antibodies reactive with SARS-CoV-2 spike (S)...
Abstract SARS‐CoV‐2 infection can damage the nervous system with multiple neurological manifestations described. However, there is limited understanding of mechanisms underlying COVID‐19 injury. This a cross‐sectional exploratory prospective biomarker cohort study 21 patients syndromes (Guillain–Barre Syndrome [GBS], encephalitis, encephalopathy, acute disseminated encephalomyelitis [ADEM], intracranial hypertension, and central pain syndrome) 23 healthy negative controls. We measured...
In early 2022, a cluster of monkeypox virus (MPXV) infection (mpox) cases were identified within the UK with no prior travel history to MPXV-endemic regions. Subsequently, case numbers exceeding 80,000 reported worldwide, primarily affecting gay, bisexual, and other men who have sex (GBMSM). Public health agencies worldwide offered IMVANEX Smallpox vaccination these individuals at high-risk provide protection limit spread MPXV. We developed comprehensive array ELISAs study poxvirus-induced...
In May, 2022, the first global outbreak of mpox (formerly known as monkeypox) occurred. response, public health agencies in UK have made smallpox vaccines available to individuals at highest risk infection. With cases still being detected globally, novel tools are required aid with diagnosis, serosurveillance, and evaluation immune responses following infection immunisation current new vaccine candidates. Here, we describe development a multiplexed immunoassay, MpoxPlex, able measure IgG 12...
The SARS-CoV-2 global pandemic has highlighted the risk of nosocomial infections airborne viruses to patient populations around world. Increased use mechanical ventilation and portable air cleaners (PACs) have been suggested as methods mitigate this risk, but introduction new flows indoor areas can complex potentially unforeseen consequences. We used particle counters investigate effect using built-in and/or PACs in a typical hospital outpatients' clinic upon spread aerosols produced by an...