A5042628274- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- Renal and related cancers
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- CRISPR and Genetic Engineering
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Acute Lymphoblastic Leukemia research
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Genomics and Rare Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Pluripotent Stem Cells Research
- Lymphoma Diagnosis and Treatment
University College London
2015-2024
The Royal Free Hospital
2014-2024
Roland Hill (United Kingdom)
2007-2024
Institute of Infection and Immunity
2015-2024
Weatherford College
2024
University Hospital Münster
2023
Ludwig-Maximilians-Universität München
2023
Centre for Immunity, Infection and Evolution
2017-2021
Royal Free London NHS Foundation Trust
2018-2020
NHS Blood and Transplant
2016-2018
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the viral entry protein, spike. Because new SARS-CoV-2 variants are emerging rapidly, as exemplified B.1.1.7, B.1.351, and P.1 lineages, it critical to understand whether antibody responses induced infection with original virus or current remain effective. In this study, we evaluate neutralization of a series mutated...
In addition to helper and regulatory potential, CD4
Abstract NP 105–113 -B*07:02-specific CD8 + T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis clones and single-cell sequencing were performed concurrently, functional avidity antiviral efficacy assessed using an vitro SARS-CoV-2 infection system, correlated receptor usage, transcriptome signature disease severity (acute n = 77, convalescent 52). demonstrated a beneficial cells...
T cell responses to MHC-mismatched transplants can be mediated via direct recognition of allogeneic MHC molecules on the cells transplant or peptides presented surface recipient APCs in - a process known as indirect recognition. As CD4(+)CD25(+) Tregs play an important role regulating alloresponses, we investigated whether mouse specific for could generated vitro and promote transplantation tolerance immunocompetent mice. able directly recognize class II (dTregs) were obtained by stimulating...
Regulatory T cells (Tregs) can suppress a wide range of immune cells, making them an ideal candidate for the treatment autoimmunity. The potential clinical translation targeted therapy with antigen-specific Tregs is hampered by difficulties isolating rare specificities from natural polyclonal cell repertoire. Moreover, initiating antigen often unknown in autoimmune disease. Here we tested ability generated retroviral gene transfer to ameliorate arthritis through linked suppression and...
Gain-of-function (GOF) mutations in the signal transducer and activator of transcription 1 (STAT1) result unbalanced STAT signaling cause immune dysregulation immunodeficiency. The latter is often characterized by susceptibility to recurrent Candida infections, resulting clinical picture chronic mucocutaneous candidiasis (CMC). This study aims assess frequency GOF STAT1 a large international cohort CMC patients. was sequenced genomic DNA from 57 patients 35 healthy family members. functional...
Adoptive transfer of Ag-specific T lymphocytes is an attractive form immunotherapy for cancers. However, acquiring sufficient numbers host-derived tumor-specific by selection and expansion challenging, as these cells may be rare or anergic. Using engineered can overcome this difficulty. Such generated using a chimeric Ag receptor based on common formats composed from Ag-recognition elements such αβ-TCR genes with the desired specificity, Ab variable domain fragments fused cell-signaling...
Abstract The thymus is a primary lymphoid organ, essential for T cell maturation and selection. There has been long-standing interest in processes underpinning generation the potential to manipulate it clinically, because alterations of development or function can result severe immunodeficiency autoimmunity. Here, we identify epithelial-mesenchymal hybrid cells, capable long-term expansion vitro, able reconstitute an anatomic phenocopy native thymus, when combined with thymic interstitial...
Abstract Determining divergent metabolic requirements of T cells, and the viruses tumours they fail to combat, could provide new therapeutic checkpoints. Inhibition acyl-CoA:cholesterol acyltransferase (ACAT) has direct anti-carcinogenic activity. Here, we show that ACAT inhibition antiviral activity against hepatitis B (HBV), as well boosting protective anti-HBV anti-hepatocellular carcinoma (HCC) cells. reduces CD8 + cell neutral lipid droplets promotes microdomains, enhancing TCR...
Regulatory T (Treg) cells, generated in vitro by Foxp3 gene transfer into naive CD4+25- have been shown to inhibit the development of inflammation and autoimmune disease, but it is not known whether they are able prevent allograft rejection. This study investigated Treg cells from CD4+ could induce transplantation tolerance.HY-specific, T-cell receptor (TCR)-transgenic were retrovirally transduced with gene. The phenotype, function, cytokine profiles examined fluorescence-activated cell...
Studies in melanoma patients have revealed that self proteins can function as targets for tumor-reactive cytotoxic T lymphocytes (CTL). One group of MAGE, BAGE, and GAGE are normally only expressed testis placenta, whilst another CTL recognized melanocyte-specific differentiation antigens. In this study we investigated whether be raised against a ubiquitously protein, mdm-2, which is frequently overexpressed tumors. The observation T-cell tolerance major histocompatibility complex-restricted...