A5075270120- Single-cell and spatial transcriptomics
- Hematopoietic Stem Cell Transplantation
- Lymphatic System and Diseases
- Childhood Cancer Survivors' Quality of Life
- T-cell and B-cell Immunology
- Phagocytosis and Immune Regulation
- Diabetes and associated disorders
- Tissue Engineering and Regenerative Medicine
- Circadian rhythm and melatonin
- Electrospun Nanofibers in Biomedical Applications
- Esophageal and GI Pathology
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Liver physiology and pathology
The Francis Crick Institute
2019-2023
Centre for Immunity, Infection and Evolution
2022-2023
University College London
2022-2023
Abstract The thymus is a primary lymphoid organ, essential for T cell maturation and selection. There has been long-standing interest in processes underpinning generation the potential to manipulate it clinically, because alterations of development or function can result severe immunodeficiency autoimmunity. Here, we identify epithelial-mesenchymal hybrid cells, capable long-term expansion vitro, able reconstitute an anatomic phenocopy native thymus, when combined with thymic interstitial...
Thymus is necessary for lifelong immunological tolerance and immunity. It displays a distinctive epithelial complexity undergoes age-dependent atrophy. Nonetheless, it also retains regenerative capacity, which, if harnessed appropriately, might permit rejuvenation of adaptive By characterizing cortical medullary compartments in the human thymus at single-cell resolution, this study we have defined specific populations, including those that share properties with bona fide stem cells (SCs)...
Abstract The human thymus is the site of T‐cell maturation and induction central tolerance. Hematopoietic stem cell (HSC)‐derived progenitors are recruited to from fetal liver during early prenatal development bone marrow at later stages postnatal life. mechanism by which HSCs poorly understood in humans, though mouse models have indicated critical role thymic stromal cells (TSC). Here, we developed a 3D microfluidic assay based on model HSC extravasation across endothelium into...
<h3>Introduction</h3> Therapeutic options for long-gap oesophageal atresia are characterized by poor outcomes with impact on the quality of life. Tissue Engineered (TE) oesophagus could help to fill this gap. Epithelization is a critical factor avoid long-term complication as strictures. Therefore, TE strategy, crucial create and maintain functional epithelium. The aim our study was test capacity pig epithelial cells (PigOEC) engraft in decellularized scaffolds an in-vitro model....