A5100461552- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
- Liver Diseases and Immunity
- Monoclonal and Polyclonal Antibodies Research
- Drug-Induced Hepatotoxicity and Protection
- Traditional Chinese Medicine Studies
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Bacteriophages and microbial interactions
- Cardiac Valve Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Alcohol Consumption and Health Effects
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Organ Transplantation Techniques and Outcomes
- COVID-19 epidemiological studies
- Cardiovascular Function and Risk Factors
- Diabetes and associated disorders
Beijing Tsinghua Chang Gung Hospital
2018-2025
Tsinghua University
2018-2025
Xiamen University
2025
Peking University
2013-2024
Tongji Hospital
2009-2024
Nankai University
2024
Zunyi Medical University
2022-2024
Fujian University of Traditional Chinese Medicine
2024
Chinese Center For Disease Control and Prevention
2014-2024
Tongji University
2024
The sudden outbreak of novel coronavirus 2019 (COVID-19) increased the diagnostic burden radiologists. In time an epidemic crisis, we hoped artificial intelligence (AI) to help reduce physician workload in regions with outbreak, and improve diagnosis accuracy for physicians before they could acquire enough experience new disease. Here, present our building deploying AI system that automatically analyzes CT images detect COVID-19 pneumonia features. Different from conventional medical AI,...
•In total, 17,374 patients with viral and non-viral hepatitis from 11 global prospective cohorts/trials were studied.•An HCC risk score (called the aMAP score, ranging 0 to 100), which involves only age, male, albumin–bilirubin platelet data, was developed validated.•The had excellent discrimination calibration in assessing 5-year irrespective of aetiology ethnicity.•Patients <50, accounting for 44% overall population, an incidence <0.2% per year. Background & AimsHepatocellular carcinoma...
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To facilitate the achieving of goal "eliminating viral hepatitis as a major public health threat by 2030" set World Health Organization, Chinese Society Hepatology together with Infectious Diseases (both are branches Medical Association) organized panel experts and updated guidelines for prevention treatment chronic B in China (version 2022). With support available evidence, this revision focuses on active prevention, large scale testing, expansion therapeutic indication aim reducing related...
Shift work is associated with increased risk of acute myocardial infarction (AMI) and worsened prognosis. However, the mechanisms linking shift prognosis in AMI remain unclear. This study sought to investigate impact on reperfusion injury, a major determinant clinical outcomes AMI. Study patient data were obtained from database EARLY-MYO-CMR (Early Assessment Myocardial Tissue Characteristics by CMR STEMI) registry, which was prospective, multicenter registry patients ST-segment elevation...
Chronic hepatitis B and its life-threatening sequelae are highly prevalent in China. There is a need for effective new therapies to suppress virus (HBV) replication ameliorate liver disease. In this study, we compared the efficacy of telbivudine, nucleoside analogue, with lamivudine Chinese patients. phase III, double-blind, multicenter trial conducted China, 332 patients compensated e antigen (HBeAg)–positive or HBeAg-negative chronic were randomly assigned treatment 600 mg telbivudine 100...
Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) sulfamoylbenzamides (SBAs), have been discovered allosterically modulate structure consequentially alter the kinetics pathway assembly, resulting in formation irregularly-shaped aggregates or "empty" capsids devoid polymerase. Interestingly,...
Alpha interferon (IFN-alpha) is an approved medication for chronic hepatitis B. Gamma (IFN-gamma) a key mediator of host antiviral immunity against B virus (HBV) infection in vivo. However, the molecular mechanism by which these cytokines suppress HBV replication remains elusive. Using immortalized murine hepatocyte (AML12)-derived cell line supporting tetracycline-inducible replication, we show this report that both IFN-alpha and IFN-gamma efficiently reduce amount intracellular...
Patients with type 2 diabetes (DM) have a higher risk of developing pulmonary tuberculosis (PTB); moreover, DM co-morbidity in PTB is associated poor treatment outcomes. Community based prevalence data on and prediabetes (pre-DM) among TB patients lacking, particularly from the world. Therefore we conducted prospective study to investigate pre-DM evaluated factors for presence newly detected rural areas China.In community carried out 2010 2012, representative sample 6382 7 clinics Linyi were...
Hepatitis B virus (HBV) infection carries substantial stigma in China. We surveyed HBV knowledge and among chronic hepatitis (CHB) patients persons without Beijing, China.Four hundred thirty five CHB 801 controls at Peking University People's Hospital were surveyed.Chronic older (mean 46 vs. 39 years) more often men (71 48%) than controls. Mean score was 11.9/15 for 9.3/15 control (P < 0.001). Average 22.1/39 19.2/30 patients. Controls expressed discomfort with close contact (45%) or sharing...
Single nucleotide polymorphisms (SNPs) near the IL28B gene have been shown to be associated with response treatment for chronic hepatitis C and also spontaneous clearance of virus (HCV) infection. We analysed association between genetic variants HCV infection in 376 HCV-infected Chinese paid plasma donors. Genotyping eight SNPs region was performed by iPLEX system (MassARRAY(®) SNP Genotyping; Sequenom) all donors, sequencing on 80 donors who cleared 160 296 did not clear validate genotypes....