A5100370483- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Traditional Chinese Medicine Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pneumonia and Respiratory Infections
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Microbial infections and disease research
- Abdominal vascular conditions and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory viral infections research
- Renin-Angiotensin System Studies
- MicroRNA in disease regulation
- Academic Publishing and Open Access
- Sinusitis and nasal conditions
- Birth, Development, and Health
Zhejiang Chinese Medical University
2025
Xinjiang Medical University
2019-2025
The First Affiliated Hospital, Sun Yat-sen University
2013-2024
Zhongshan Hospital
2013-2024
Fudan University
2013-2024
Sun Yat-sen University
2013-2024
Sun Yat-sen University Cancer Center
2024
Shanghai Institute of Hematology
2020-2024
Beijing Center for Disease Prevention and Control
2024
Army Medical University
2012-2023
The epithelial-mesenchymal transition (EMT) and angiogenesis have emerged as two pivotal events in cancer progression. Curcumin has been extensively studied preclinical models clinical trials of prevention due to its favorable toxicity profile. However, the possible involvement curcumin EMT lung remains unclear. This study found that inhibited hepatocyte growth factor (HGF)-induced migration EMT-related morphological changes A549 PC-9 cells. Moreover, pretreatment with blocked HGF-induced...
Abstract Background Hepatic fibrosis is a common pathologic stage in chronic liver disease development, which might ultimately lead to cirrhosis. Accumulating evidence suggests that adipose-derived stromal cells (ADSCs)-based therapies show excellent therapeutic potential injury owing its superior properties, including tissue repair ability and immunomodulation effect. However, cell-based therapy still limits several problems, such as engraftment efficiency immunoreaction, impede the...
The effectiveness and risks of anticoagulant therapy in cirrhotic patients with non-symptomatic portal vein thrombosis (PVT) remain unclear. We conducted a multicenter, Zelen-designed randomized controlled trial to determine the warfarin PVT during one-year follow-up. In brief, 64 were 1:1 randomly divided into anticoagulation group or untreated group. probability recanalization was significantly higher than those both ITT analysis (71.9% vs 34.4%, p = 0.004) PP (76.7% 32.4%, < 0.001)....
For patients with large unresectable hepatocellular carcinoma (HCC), the effectiveness of conventional transarterial chemoembolization (cTACE) remains suboptimal. This study investigated efficacy and safety modified TACE using low-dose chemotherapy blank microspheres (BMS-TACE) plus lenvatinib (LD-LEN) microwave ablation (MWA) in HCC.
Abstract Background and Aim Current guidelines recommend injection of cyanoacrylate as first‐line therapy to prevent gastric variceal rebleeding. The method still poses a risk ectopic embolism, which possibly correlates with the volume used. In this trial, we evaluated short‐term efficacy safety tissue adhesive combined lauromacrogol for treating varices. Methods Patients admitted our hospital hemorrhage were enrolled blindly randomized into two treatment groups: group...
The clinical features, treatment, and prognosis of allergic bronchopulmonary aspergillosis (ABPA) are not well-defined.We aimed to investigate the characteristics, therapy, ABPA aid its recognition.A total 232 patients with were analyzed retrospectively. characteristics in terms misdiagnosis, computed tomography classification, relationship asthma analyzed, risk factors for acute exacerbation based on follow-up data.Of patients, 132 had a history misdiagnosis. Compared misdiagnosed central...
Abstract Introduction This study aimed to elucidate the relationship between neutrophil‐to‐lymphocyte ratio (neutrophil–lymphocyte ratio, NLR) and 28‐day mortality in critically ill elderly sepsis patients. Methods Retrieval of information on patients > 65 years age who meet diagnostic criteria for 3.0 using Medical Information Marketplace Intensive Care‐IV (MIMIC‐IV) database. Optimal NLR truncation was identified X‐tile software corresponding Kaplan–Meier (K‐M) survival curves were...
Rationale: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia is a severe and rapidly progressing infection that can lead to acute respiratory distress syndrome septic shock. The use of venovenous extracorporeal membrane oxygenation (ECMO) may improve outcomes in critically ill patients who fail conventional mechanical ventilation. Patient concerns: Two female patients, aged 14 32 years, presented with fever cough before hospital admission. Both developed...
Acute lung injury (ALI) is a severe inflammatory disease, for which no specific treatment exists. The decreased ratio of regulatory T cells (CD4+ CD25+ FoxP3 Tregs) and Th17 implicated in ALI inflammation. We here investigated whether maintaining the balance CD4+ Foxp3+ Tregs can alleviate injury. For Treg depletion, 200 μg an anti-CD25 antibody was administered intraperitoneally per mouse on days -3 -1 before lipopolysaccharide (LPS) instillation. And 150 TGF-β day 0 after LPS To...
To assess the effects of TCHM on patients with HIV infection and AIDS, we reviewed eleven randomized placebo-controlled trials involving 998 patients. Due to limited number RCTs for included small sample size each study, are not able draw firm conclusions concerning therapy in treating AIDS. However, some high-quality clinical studies do exist. Studies diarrhea oral candidiasis, which challenging symptoms were demonstrated have positive effects. Study peripheral leukocytes, a side effect...
Stem cell factor (SCF), a ligand of c-kit, is hematopoietic growth factor. Uncontrolled activity SCF/c-kit signaling pathway contributes to the formation variety human malignancies. In this study, we determined whether SCF expression could risk-stratify patients with hepatocellular carcinoma (HCC) after curative resection. HCC tissues from 160 were collected during resection and stained CD34, marker for microvessel density (MVD), using immunohistochemistry. Two statistical analyses...
Commercial plasma donation was introduced in China the 1970s. Cases of non-A, non-B hepatitis (hepatitis C) continued to occur, with multiple outbreaks among donors Guan county, Hebei province between 1972 and 1990. The outcomes C virus (HCV) infection these paid from six villages county were followed up for 12-19 years.A total 402 HCV enrolled since anti-HCV-positive 1991 or 1998. Follow maintained until death end observation period. No antiviral treatment applied during period...
Background Low self-efficacy in chronic disease patients is one of the main disturbances which require physical and mental rehabilitation, calling for development a home accessible way to improve self-management. Objectives The purpose this study was explore effectiveness community based Baduanjin exercise on adults with cardiovascular disease. Design A randomized controlled trial, longitudinal research design employed. Participants After screening by health documents Community Health...
Hepatic progenitor cells, capable of maturing into hepatocytes and biliary are hypothesized to be involved in all forms liver regeneration may prove clinically useful at reconstituting damaged livers. A murine hepatic cell population from young adult tissue has been isolated characterized establish a model for the development therapies analysis immune responses after transplantation. cells were 3- 6-week-old C57BL/6 mice using modifications two-stage perfusion technique followed by low speed...
Hepatic cirrhosis is a common pathway of progressive liver destruction from multiple causes. Iron uptake can occur within the hepatic parenchyma or various nodules that form in cirrhotic liver, termed siderotic nodules. Siderotic nodule formation has been shown to correlate with inflammatory activity, and while relationship between malignancy remains unclear, iron distribution known implications for detection hepatocellular carcinoma. We aimed evaluate role abdominal susceptibility-weighted...
The etiology and pathogenesis of pancreatitis remains unclear. In the presence pancreatic inflammation, metabolite abnormalities appear before transformation tissue structure changes in functions occur. Detection levels facilitates a greater understanding pathophysiological events aids early diagnosis disease. this study, metabolic profiles from pancreas Wistar rats were examined using high-resolution proton magic angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy to...
A recently published network meta-analysis showed that ligation combined with sclerotherapy might be the most efficacious intervention for secondary prophylaxis of variceal bleeding. Most studies excluded patients concomitant gastric varices; thus, outcomes in such have not yet been reported. The present study aimed to investigate efficacy two endoscopic procedures cirrhotic presenting both esophageal and varices.A randomized controlled was carried out a tertiary care referral center....
To compare the long-term outcomes of combined transarterial chemoembolization and radiofrequency ablation (TACE-RFA) with (RFA) monotherapy for small (≤3 cm) hepatocellular carcinomas (HCCs).A total 248 patients 329 HCC nodules who underwent TACE-RFA or RFA as only first-line treatment between January 2009 December 2020 were included in this study. The technical success, complications, survival rate, local tumor progression (LTP) rate compared two treatments.The 1-, 3- 5-year rates similar...