A5021503189- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Wnt/β-catenin signaling in development and cancer
- Gastroesophageal reflux and treatments
- Galectins and Cancer Biology
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Diet, Metabolism, and Disease
- Gastrointestinal Bleeding Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Stress, Anesthesia, and Immune Response
Lanzhou University
2016-2025
First Hospital of Lanzhou University
2016-2025
Xuzhou Medical College
2025
Gansu University of Traditional Chinese Medicine
2020
Sichuan University
2008
West China Hospital of Sichuan University
2008
GNS Healthcare (United States)
2007
Southwest Hospital
2002-2005
Army Medical University
2002-2005
University Gastroenterology
2005
Dysregulated miRNAs in gastric cancer are usually screened by miRNA microarray from clinical samples, however, reports have indicated that results of each screening considerably different, and dysregulated miRNAs, especially downregulated were contradictory. In view this, the Human Cancer Pathway Finder PCR array was applied to compare 7 cell lines AGS, SGC-7901, MKN-45, MKN-28, MGC-803, BCG-823, HGC-27 with an immortalized normal line, GES-1 pathway-related expression profile, followed qPCR...
Gastric cancer, one of the most common malignancies worldwide, typically has a poor prognosis and survival rate. Previous studies have investigated chemopreventive effect celecoxib. In present study, SGC-7901 human gastric cancer cell line was utilized to examine mechanisms The inhibition proliferation determined using MTT assay, apoptosis monitored by terminal deoxynucleotidyl transferase-mediated dUTP nick end‑labeling (TUNEL) flow cytometry, ultrastructural changes were assessed via...
Abstract Background Dietary carotenoids have been proven to improve intestinal disorders like inflammatory bowel disease and colon cancer, yet little is known about the link between dietary constipation. This study aims examine relationship intake constipation, using data from National Health Nutrition Examination Survey (NHANES) 2005–2010. Methods A total of 11,722 participants were enrolled. Chronic constipation was defined as type 1 (separate hard lumps, nuts) 2 (sausage-like, but lumpy)...
Background: Observational studies have previously shown a possible link between fatty acids and aging-related diseases, raising questions about its health implications. However, the causal relationship two remains uncertain. Methods: Univariable multivariable Mendelian randomization (MR) was used to analyze five types of acids—polyunsaturated acid (PUFA), monounsaturated (MUFA), saturated (SFA), Omega-6 (Omega-6 FA), Omega-3 (Omega-3 FA) three markers aging: telomere length (TL), frailty...
The E-cadherin-catenin complex is important for cell-cell adhesion of epithelial cells. Impairment one or more components this associated with poor differentiation and increased invasiveness carcinomas. We evaluated the expression pattern E-cadherin beta-catenin in gastric carcinoma dysplasia analyzed their relationship tumor clinicopathological features patient survival.Immunohistochemical staining was performed from paraffin specimens 163 carcinomas, 44 mucosal dysplasia, 25 intestinal...
Portal hypertensive gastropathy is an important complication of liver cirrhosis and it contributes to acute gastric bleeding. Effective management this condition remains a clinical challenge. We assessed compared the efficacy octreotide, vasopressin, omeprazole in treatment bleeding patients with portal gastropathy.Sixty-eight were randomized into Octreotide, Vasopressin, Omeprazole groups. Bleeding was monitored by observing contents nasogastric tube. Blood transfusion requirements...
Abstract Aim: To evaluate the efficacy and safety of celecoxib combined with chemotherapy in treatment metastatic or postoperative recurrent gastric cancer. Methods: This preliminary, three-center, clinical trial study was conducted between September 2010 December 2016. In experimental group (n = 100), patients were treated chemotherapy, alone used control group. Progression-free survival (PFS) considered as primary parameter. Overall (OS), remission rate (RR), quality life (QOL) drug...
Cyclooxygenase-2 (COX-2) participates in cancer invasion and metastasis by decreasing the expression of E-cadherin. However, molecular mechanisms through which COX-2 regulates E-cadherin function have not yet been fully elucidated. The aim this study was to investigate possible gastric cancer. mRNA protein COX-2, nuclear factor-κB (NF-κB), Snail detected cells quantitative PCR western blot analysis, respectively. these genes also healthy mucosa tissues immunohistochemistry. We various levels...
The aim of the present study was to screen for and identify microRNAs (miRNAs/miRs) that are associated with gastric cancer clarify role these miRNAs in cancer. Thus, differential expression a panel two pairs tissues their matched adjacent healthy investigated by performing microarray analysis. To verify results this screen, 56 were analyzed selected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). association between specific miRNA clinical data relating tissue...
To evaluate the prevalence of Helicobacter pylori infection and risk factors to serotype strains in Wuwei, located north-western China, which has a high incidence gastric cancer. was analysed 21 291 adults by 14 C-urea breath test, H. antibody were detected 9183 serum samples latex immunoturbidimetric method. The correlation with demographic-economic, lifestyle medical history among participants determined questionnaire. antibodies against urease, VacA CagA dot immunobinding assay. rate...
Background: To date, the pathogenesis of gastric cancer (GC) remains unclear.We combined public database resources and bioinformatics analysis methods, explored some novel genes verified experiments to further understand GC provide a promising target for anti-tumor therapy. Methods:We downloaded chip data related from Gene Expression Omnibus (GEO) database, extracted differentially expressed (DEGs), then determined key in development via PPI networks model analysis.Functional annotation GO...
E-cadherin, vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMPs) are important molecules involved in tumor metastasis. In this study, we examined the expressions of VEGF, MMP-1, MMP-2, microvessel density (MVD), as well microlymphatic vessel (MLVD) 200 cases gastric cancer tissues, determined relationship between these parameters clinicopathological features patient survival. Protein expressions, MVD, MLVD were detected by immunohistochemistry. The correlation...
Background: Hepatocellular carcinoma (HCC) is one of the highly heterogeneous cancers that lacks an effective risk model for prognosis prediction. Therefore, we searched angiogenesis-related immune genes affected HCC to construct a and studied role this in HCC. Methods: In study, collected transcriptome data from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) database. Pearson correlation analysis was performed identify association between genes. Consensus clustering applied...
Several risk factors have been identified for the development of gastric adenocarcinoma (GAC), where control group was usually a healthy population. However, it is unclear at what stage known factor exert their influence toward progression to cancer. Based on Wuwei Cohort, we enrolled 1,739 patients with chronic non-atrophic gastritis (no-CAG), 3,409 atrophic (CAG), 1,757 intestinal metaplasia (IM), 2,239 low-grade dysplasia (LGD), and 182 high-grade (HGD) or GAC assess between each two...
Gastric cancer is one of the common malignant tumors digestive system worldwide, posing a serious threat to human health. A growing number studies have demonstrated important role that lipid droplets play in promoting progression. However, few systematically evaluated droplet metabolism-related genes (LDMRGs) patients with gastric cancer.