A5064509655- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Magnetic properties of thin films
- Intensive Care Unit Cognitive Disorders
- Lipid metabolism and disorders
- Alcohol Consumption and Health Effects
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Liver Disease and Transplantation
- Gastrointestinal motility and disorders
- RNA modifications and cancer
First Hospital of China Medical University
2017-2025
China Medical University
2017-2025
Fujian Medical University
2015-2025
Union Hospital
2010-2025
Guangzhou First People's Hospital
2016-2025
Guangzhou Medical University
2016-2025
South China University of Technology
2018-2025
First Affiliated Hospital of Zhengzhou University
2024-2025
Fujian Provincial Hospital
2024
Putian University
2024
Abstract Rationale: Fecal microbiota transplantation (FMT) is recognized as an emerging treatment through reconstruction of gut microbiota. Parkinson's disease a neurodegenerative disorder, which accompanied by constipation. Here we first reported patient with and constipation that were obviously relieved after FMT. Patient concerns: A 71-year-old male presented 7 years resting tremor, bradykinesia (first inflicted the upper limbs subsequently spread to lower limbs), intractable (defecation...
AIM:To investigate the population-based prevalence of fatty liver disease (FLD) and its risk factors in Guangdong Province, China. METHODS:A cross-sectional survey with multiple-stage stratified cluster random sampling inhabitants over 7-year-old was performed 6 urban rural areas China.Questionnaires, designed by co-working epidemiologists hepatologists, included demographic characteristics, current medication use, medical history health-relevant behaviors, i.e., alcohol consumption, smoking...
The factors driving the composition of gut microbiota are still only partly understood but appear to include environmental, cultural, and genetic factors. In order obtain more insight into relative importance these factors, we analyzed microbiome in subjects Tibetan or Han descent living at different altitudes. DNA was isolated from stool samples. Using polymerase chain reaction methodology, 16S rRNA V1–V3 regions were amplified sequence information by principal coordinates analysis Lefse...
Primary or secondary mutations in
Abstract Background Dextran sulfate sodium (DSS) replicates ulcerative colitis (UC)-like in murine models. However, the microbial characteristics of DSS-triggered require further clarification. To analyze changes gut microbiota associated with DSS-induced acute and chronic colitis. Methods Acute was induced mice by administering 3% DSS for 1 week drinking water, supplementing water 2.5% every other 5 weeks. Control groups received same without supplementation. The histopathological score...
Magnetic skyrmions with a well-defined spin texture have shown unprecedented potential for various spintronic applications owning to their topologically non-trivial and quasiparticle properties. To put into practical technology, efficient manipulation, especially the inhibition of skyrmion Hall effect (SkHE) has been intensively pursued. In spite recent progress made on reducing SkHE in several substituted systems, such as ferrimagnets synthetic antiferromagnets, organized creation current...
Abstract Background and Aim Fexuprazan is a novel potassium‐competitive acid blocker (P‐CAB). This study aimed to explore the noninferior efficacy safety of fexuprazan esomeprazole in treating erosive esophagitis (EE). Methods was phase III, randomized, double‐blind multicenter study. Patients with endoscopically confirmed EE were randomized receive 40 mg or once daily for 4–8 weeks. The healing rates EE, symptom response, GERD‐health‐related quality life (GERD‐HRQL), treatment‐emergent...
The effect of photobiomodulation on delayed onset muscle soreness remains unknown. This study represents the first investigation this treatment using an animal model.Seventy-two Sprague-Dawley rats were randomly divided into five groups: sedentary control group, exercise group and three exercise-plus-laser groups. Downhill running was used to induce injury in gastrocnemius muscle. He-Ne laser irradiations administered injured muscles immediately at 18 42 h after groups 12, 28, 43 J/cm2,...
To quantify Fusobacterium spp., Enterococcus faecalis (E.faecalis), Enterotoxigenic Bacteroides fragilis (ETBF), and Enteropathogenic Escherichia coli in colorectal cancer (CRC) patients their possible association with CRC clinicopathogical features, we collected the resected tumors adjacent normal tissues (N) from 97 patients. 48 age- sex-matched healthy controls (HC) were also recruited. Real-time PCR was used for bacterial quantification. The median abundance ofFusobacterium spp.(p <...
Abstract Acquired immune deficiency syndrome ( AIDS ), caused by infection with human immunodeficiency virus HIV is associated gastrointestinal disease, systemic activation and changes in the gut microbiota. Here, we aim to investigate microbiota patterns of ‐infected individuals ‐uninfected populations from South China. We enrolled 33 patients (14 participants treated highly active antiretroviral therapy [ HAART ] for more than 3 months; remaining 19 had not received treatment) 35 healthy...
Fecal microbiota transplantation (FMT) can inhibit the progression of ulcerative colitis (UC). However, how FMT modulates gut and which biomarker is valuable for evaluating efficacy have not been clarified. This study aimed to determine changes in their relationship with butyric acid following UC. (FM) was isolated from healthy individuals or mice transplanted into 12 UC patients induced by dextran sulfate sodium (DSS). Their clinical severities were monitored. analyzed 16S sequencing...
To evaluate the diagnostic performance of ultrasound attenuation parameter (UAP) and liver stiffness measurement (LSM) by FibroTouch for diagnosis hepatic steatosis fibrosis in patients with nonalcoholic fatty disease (NAFLD).We recruited 237 undergoing biopsy within 2 weeks. The pathological findings were scored Nonalcoholic Steatohepatitis Clinical Research Network, accuracy UAP LSM was evaluated area under receiver operating characteristic curve (AUROC). impacts histological parameters on...
Abstract Background and Aim: The aim of this study was to investigate the influence polygenetic polymorphisms, which play a role in pathogenesis metabolic syndrome, on susceptibility non‐alcoholic fatty liver disease (NAFLD) Chinese people. Methods: subjects were selected from an epidemiological survey Guangdong province southern China. In each polymorphism study, 50–117 who met diagnostic criteria NAFLD had typical clinical ultrasonographic findings placed into case group. Using nested...
Autophagy and gut microbiota correlates closely with the inflammatory bowel disease. Herein, we aimed to study roles of rapamycin on in disease.Acute colitis was induced dextran sodium sulfate (DSS) 2,4,6-trinitrobenzenesulfonic acid solution mice. Mice were administered or hydroxychloroquine. Weight loss, disease activity index scores, histopathological score, serum cytokines, intestinal permeability, colonic autophagy-related proteins detected. Cecal content also preserved liquid nitrogen...
Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the association DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD.50 male SD rats were randomly divided into five groups with or without high fat diet (HFD), antibiotics, probiotics, order establish an imbalanced probiotic treatment model NAFLD rats. After 13 weeks treatment, blood, liver,...
Oropharyngeal microbiomes play a significant role in the susceptibility and severity of COVID-19, yet these for development COVID-19 Omicron variant have not been reported. A total 791 pharyngeal swab samples were prospectively included this study, including 297 confirmed cases (CCO), 222 case who recovered (CCOR), 73 original strain (CCOS) 199 healthy controls (HC). All completed MiSeq sequencing. The results showed that compared with HC, conditional pathogens increased CCO, while...
Background: Delivery of therapeutic small interfering RNA (siRNA) via functionalized nanoparticles holds great promise for cancer therapy. However, developing a safe and efficient delivery carrier siRNA is challenging issue. Methods: RGDfC peptide was used to modify the surface selenium (SeNPs) synthesize biocompatible vehicle (R-SeNPs), MEF2D-siRNA loaded onto R-SeNPs prepare nanoparticle [email protected] The chemical properties were characterized, anticancer efficacy as well related...