A5037658093- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Extracellular vesicles in disease
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Colorectal and Anal Carcinomas
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Peking Union Medical College Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Third Affiliated Hospital of Inner Mongolia Medical College
2025
Xinxiang Medical University
2023-2025
First Affiliated Hospital of Xinxiang Medical University
2023-2025
Beijing Normal University
2023-2025
Qinghai Red Cross Hospital
2025
Qinghai University
2025
Huashan Hospital
2025
Purpose There is currently no standard treatment strategy for patients with advanced metastatic gastric cancer experiencing progression after two or more lines of chemotherapy. We assessed the efficacy and safety apatinib, a novel vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor, in gastroesophageal junction adenocarcinoma whom at least prior chemotherapy had failed. Patients Methods This was randomized, double-blind, placebo-controlled phase III trial. from 32 centers...
Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated fibroblasts (CAFs) support tumor progression and drug resistance secreting various bioactive substances, including exosomes. Yet, the role CAFs regulating metabolism as well ferroptosis cancer cells still unexplored remains enigmatic.Ferroptosis-related genes gastric (GC) were screened using mass spectrum; exosomes isolated...
<h3>Importance</h3> Standard first-line therapy for advanced or metastatic esophageal carcinoma is chemotherapy, but the prognosis remains poor. Camrelizumab (an anti–programmed death receptor 1 [PD-1] antibody) showed antitumor activity in previously treated squamous cell carcinoma. <h3>Objective</h3> To evaluate efficacy and adverse events of camrelizumab plus chemotherapy vs placebo as a treatment <h3>Design, Setting, Participants</h3> This randomized, double-blind, placebo-controlled,...
Abstract The metastatic organotropism has been one of the cancer’s greatest mysteries since ‘seed and soil’ hypothesis. Although role EGFR in cancer cells is well studied, effects secreted transported by exosomes are less understood. Here we show that from gastric can be delivered into liver integrated on plasma membrane stromal cells. translocated proved to effectively activate hepatocyte growth factor (HGF) suppressing miR-26a/b expression. Moreover, upregulated paracrine HGF, which binds...
Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, PKM2 expression varies even within single tumor. In this study, we confirmed that is heterogeneous CRC cells, namely high oxaliplatin-resistant cells but relatively low sensitive found chemoresistant had enhanced production. addition, report...
High tumor mutational burden (TMB-H) is correlated with enhanced objective response rate (ORR) and progression-free survival (PFS) for certain cancers receiving immunotherapy. This study aimed to investigate the safety efficacy of toripalimab, a humanized programmed death-1 (PD-1) antibody, in advanced gastric cancer (AGC), predictive benefit TMB PD-L1.
Abstract BACKGROUND Detection of pancreatic cancer (PaC), particularly at early stages, remains a great challenge owing to lack specific biomarkers. We sought identify PaC-specific serum microRNA (miRNA) expression profile and test its specificity sensitivity as biomarker in the diagnosis prognosis PaC. METHODS obtained samples from 197 PaC cases 158 age- sex-matched cancer-free controls. screened differentially expressed miRNAs with Illumina sequencing by synthesis technology using pooled...
Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in energy storage metabolism regulation by secretion adipokines. Circular RNAs (circRNAs), a novel type noncoding RNA, have recently been recognized as key factors tumor development, but role exosome circRNAs derived from adipose tissues not defined yet. Here, adipose-secreted were found regulate deubiquitination HCC, thus facilitating cell...
The detection of nonsmall cell lung cancer (NSCLC) at an early stage presents a daunting challenge due to the lack specific noninvasive marker. discovery microRNAs (miRNAs), particularly those found in serum, has opened new avenue for tumor diagnosis. To determine whether expression profile serum miRNAs can serve as NSCLC fingerprint, we performed Taqman probe-based quantitative RT-PCR assay selected differentially expressed from sample set including 400 cases and 220 controls, risk score...
Cancer‐related cachexia is a metabolic syndrome characterized by wasting disorder of adipose and skeletal muscle accompanied body weight loss systemic inflammation. The treatment options for cancer are limited, the molecular mechanism remains poorly understood. Circular RNAs (circRNAs) novel family endogenous noncoding that have been proposed to regulate gene expression in mammals. Exosomes small vesicles derived from cells, recent studies shown circRNAs stable exosomes. However, little...
Chemoresistance is one of the causes adverse effects in gastric cancer, including a poor response to cisplatin (DDP). Exosomes loaded with microRNA (miRNA), mRNA, and other non-coding RNAs could regulate drug resistance. Exo-anti-214 was extracted verified. A Cell Counting Kit-8 (CCK-8) cell viability assay, flow cytometry, transwell immunofluorescence assays were performed determine whether exo-anti-214 sensitize cells DDP vitro. combination intravenously injected intraperitoneal utilized...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editors. Molecular Therapy is retracting this article. After investigating concerns image duplication raised by a reader, evidence for in identical or altered fashion Figures 4A, 4G, and S1C was identified. reuse (and part, misrepresentation) data without appropriate attribution represents severe abuse scientific publishing system....
Hypoxia is one of the important properties solid tumor. However, oxygen supply within tumors generally heterogeneous according to distance from nearest blood vessel. The discrepancy metastatic potential exists between hypoxic cancer cells and relatively normoxic cells. But molecular mechanism remains poorly understood.
Abstract Background Current treatment options for human epidermal growth factor receptor 2 (HER2)‐overexpressing gastric cancer at third‐line have shown limited clinical benefit. Further, there is no specific HER2 immunohistochemistry (IHC) 2+ and fluorescence in‐situ hybridization‐negative patients. Here, we report the efficacy safety of a novel anti‐HER2 antibody RC48 patients with HER2‐overexpressing, advanced or gastroesophageal junction cancer. Methods Patients HER2‐overexpressing (IHC...
Abstract Obesity is closely related to a poor prognosis in patients with advanced colorectal cancer (CRC), but the mechanisms remain unclear. Ferroptosis form of nonapoptotic cell death characterized by lipid reactive oxygen species (ROS) accumulation and iron dependency associated chemoresistance tumors. Here, it shown that adipose‐derived exosomes reduce ferroptosis susceptibility CRC, thus promoting oxaliplatin. It found microsomal triglyceride transfer protein (MTTP) expression increased...
Oxaliplatin resistance is a challenge in the treatment of colorectal cancer (CRC) patients. Regulatory T cells (Tregs) are well known for their immunosuppressive roles, and targeting Tregs an effective way to improve chemosensitivity. Exosome-delivered microRNA (miRNA) might be used as potential biomarker predicting However, relationship between exosomal miRNAs remains largely unknown. TaqMan low-density array was performed screen differentially expressed serum from pooled patients who had...
Abstract Purpose RC48 contains the novel humanized anti-HER2 antibody hertuzumab conjugated to MMAE via a cleavable linker. A phase I study was initiated evaluate toxicity, MTD, PK, and antitumor activity of in patients with HER2-overexpressing locally advanced or metastatic solid carcinomas, particularly gastric cancer. Patients methods This 2-part study. Successive cohorts received escalating doses (0.1 mg/kg, 0.5 1.0 2.0 2.5 3.0 mg/kg). Dose expansion proceeded at dose mg/kg Q2W. The...