A5101778227- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Protein Kinase Regulation and GTPase Signaling
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Obesity, Physical Activity, Diet
- PI3K/AKT/mTOR signaling in cancer
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Cardiovascular Health and Risk Factors
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Adipokines, Inflammation, and Metabolic Diseases
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Coffee research and impacts
- Advanced Sensor and Energy Harvesting Materials
- Cancer, Lipids, and Metabolism
- Melanoma and MAPK Pathways
Harvard University
2016-2025
Capital Medical University
2024-2025
Beijing Friendship Hospital
2025
Shandong University
2025
Xinjiang Medical University
2013-2024
Huazhong University of Science and Technology
2010-2024
Shanghai Jiao Tong University
2024
Brigham and Women's Hospital
2013-2024
Joslin Diabetes Center
2024
Nanfang Hospital
2022-2024
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects European ancestry after imputation using 1000 Genomes multiethnic reference panel. Promising signals were followed up in additional sets (of 14,545 or 7,397 38,994 71,604 subjects). We identified 13 novel T2D-associated loci (P < 5 × 10-8), including variants near GLP2R, GIP, HLA-DQA1...
Looking for fragments: A fragment-based screen using NMR spectroscopy was applied to discover ligands that bind the GTPase K-Ras and modulate activity of nucleotide exchange factor Sos. Structural data on how these fragment-derived hits guanosine diphosphate–K-Ras complex (see picture) provides a starting point future discovery drugs target activation signaling. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not...
The 3 human RAS genes, KRAS, NRAS, and HRAS, encode 4 different proteins which belong to the protein family of small GTPases that function as binary molecular switches involved in cell signaling. Activating mutations are among most common oncogenic drivers cancers, with KRAS being frequently mutated oncogene. Although is an excellent drug discovery target for many despite decades research, no therapeutic agent directly targeting has been clinically approved. Using structure-based design, we...
Prospective evidence regarding associations for exposures to bisphenol A (BPA) and phthalates with type 2 diabetes (T2D) is lacking.We prospectively examined urinary concentrations of BPA phthalate metabolites T2D risk.We measured eight major among 971 incident case-control pairs from the Nurses' Health Study (NHS) (mean age, 65.6 years) NHSII 45.6 years).In NHSII, levels were not associated in multivariate-adjusted analysis until body mass index was adjusted: odds ratio (OR) comparing...
The association between consumption of caffeinated and decaffeinated coffee risk mortality remains inconclusive.We examined the associations total, caffeinated, with subsequent total cause-specific among 74,890 women in Nurses' Health Study (NHS), 93,054 II, 40,557 men Professionals Follow-up Study. Coffee was assessed at baseline using a semiquantitative food frequency questionnaire. During 4,690,072 person-years follow-up, 19,524 12,432 died. Consumption were nonlinearly associated...
Abstract Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in leptin ( LEP ) gene are well known to cause deficiency and severe obesity, no common loci regulating have been uncovered. Therefore, we performed a genome-wide association study (GWAS) from 32,161 individuals followed up reaching P <10 −6 19,979 additional individuals. We identify five robustly associated <5 × 10 −8 in/near , SLC32A1...
Abstract Highly stretchable aerogel films are attractive for advanced next‐generation electronics. However, it is a great challenge to achieve high stretchability films. Here, several types of unprecedented ultra‐stretchable semiconducting polymer‐based with crimpled porous structures developed via crosslinking and template methods combined uniaxial biaxial pre‐stretching strategies. The obtained by exhibit ultrahigh up 100–200%, while those show 50%. resulting strain‐insensitive electrical...
To identify type 2 diabetes (T2D) susceptibility loci, we conducted genome-wide association (GWA) scans in nested case–control samples from two prospective cohort studies, including 2591 patients and 3052 controls of European ancestry. Validation was performed 11 independent GWA studies 10 870 cases 73 735 controls. We identified significantly associated variants near RBMS1 ITGB6 genes at 2q24, best-represented by SNP rs7593730 (combined OR = 0.90, 95% CI 0.86–0.93; P 3.7 × 10−8). The...
Significance Ras is one of the most highly validated targets in cancer; however, discovery potent inhibitors has been difficult to achieve. We report small molecules that bind a pocket on Ras:Son Sevenless:Ras complex and alter activity biochemical cell-based experiments. High-resolution cocrystal structures define protein–ligand interactions, lead compounds provide starting point for signaling.
Blood soluble E-selectin (sE-selectin) levels have been related to various conditions such as type 2 diabetes. We performed a genome-wide association study among women of European ancestry from the Nurses' Health Study, and identified significant associations between cluster markers at ABO locus (9q34) plasma sE-selectin concentration. The strongest was with rs651007, which explained ∼9.71% variation in concentrations. SNP rs651007 also nominally associated intracellular cell adhesion...
Coffee consumption has been associated with a lower risk of type 2 diabetes in prospective cohort studies, but the underlying mechanisms remain unclear. The aim this study was to evaluate effects regular and decaffeinated coffee on biological factors for diabetes. Randomized parallel-arm intervention conducted 45 healthy overweight volunteers who were nonsmokers consumers. Participants assigned 5 cups (177 mL each) per day instant caffeinated coffee, or no (i.e., water) 8 weeks. Average age...
Activating mutations in KRAS are the most frequent oncogenic alterations cancer. The hotspot position 12, located at lip of switch II pocket, offers a covalent attachment point for KRASG12C inhibitors. To date, inhibitors have been discovered by first covalently binding to cysteine 12 and then optimizing pocket binding. We report on discovery vivo active inhibitor BI-0474 using different approach, which small molecules that bind reversibly were identified optimized non-covalent...
Abstract Background Epigenetic alterations have been shown to contribute immensely human carcinogenesis. Dynamic and reversible N6‐methyladenosine (m6A) RNA modification regulates gene expression cell fate. However, the reasons for activation of KIAA1429 (also known as VIRMA, an methyltransferase) its underlying mechanism in lung adenocarcinoma (LUAD) remain largely unexplored. In this study, we aimed clarify oncogenic role tumorigenesis LUAD. Methods Whole‐genome sequencing transcriptome...
Abstract Highly sensitive self‐powered stretchable electronic skins with the capability of detecting broad‐range dynamic and static pressures are urgently needed increasing demands for miniaturized wearable electronics, robots, artificial intelligence, etc. However, it remains a great challenge to achieve this kind skins. Here, unprecedented battery‐type all‐in‐one novel structure composed pressure‐sensitive elastic vanadium pentoxide (V 2 O 5 ) nanowire‐based porous cathode, polyurethane...
Super enhancers (SE) play pivotal roles in cell identity and diseases occur including tumorigenesis. The depletion of SE-associated lncRNA transcripts, also known as super-lncRNA, causes the activity SE to be dysregulated.We screened identified an elevated metastasis-associated SE-lncRNA SUCLG2-AS1 nasopharyngeal carcinoma (NPC) using RNA-sequencing, real-time quantitative polymerase chain reaction (RT-qPCR) bioinformatics. Western blotting, RT-qPCR, methylated RNA immunoprecipitation...