Jerome I. Rotter
A5040770914- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Genetic Mapping and Diversity in Plants and Animals
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Birth, Development, and Health
- Genetic and phenotypic traits in livestock
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Helicobacter pylori-related gastroenterology studies
- Retinal Diseases and Treatments
- Cancer, Lipids, and Metabolism
University of California, Los Angeles
2016-2025
Harbor–UCLA Medical Center
2016-2025
The Lundquist Institute
2016-2025
UCLA Medical Center
2016-2025
Los Angeles Medical Center
2015-2024
University of Alabama at Birmingham
2007-2024
University of South Dakota
2023-2024
University of Cambridge
2016-2024
Johns Hopkins Medicine
2006-2024
Johns Hopkins University
2006-2024
The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic disorders that cause abdominal pain, diarrhea, gastrointestinal bleeding. To identify genetic factors might contribute to these disorders, we performed a genome-wide association study. We found highly significant between the IL23R gene on chromosome 1p31, which encodes subunit of receptor for proinflammatory cytokine interleukin-23. An uncommon coding variant (rs11209026, c.1142G>A, p.Arg381Gln)...
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified genetic sharing 25 disorders from genome-wide association studies 265,218 patients 784,643 control participants assessed relationship to 17 phenotypes 1,191,588 individuals. Psychiatric common variant risk, whereas neurological appear more distinct one another psychiatric disorders. also identified significant between a number...
The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community interacts immune system through innate receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was result of altered responses indigenous fungi. In humans, identified polymorphism in gene for (CLEC7A) is strongly linked severe form...
Background Mild retinopathy (microaneurysms or dot-blot hemorrhages) is observed in persons without diabetes hypertension and may reflect microvascular disease other organs. We conducted a genome-wide association study (GWAS) of mild diabetes. Methods A working group agreed on phenotype harmonization, covariate selection analytic plans for within-cohort GWAS. An inverse-variance weighted fixed effects meta-analysis was performed with GWAS results from six cohorts 19,411 Caucasians. The...
Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density (HDL) cholesterol. It is not known whether such or therapeutic antagonism ANGPTL3 are a reduced risk atherosclerotic cardiovascular disease.
Background— The primary aim of genome-wide association studies is to identify novel genetic loci associated with interindividual variation in the levels risk factors, degree subclinical disease, or clinical disease. requirement for large sample sizes and importance replication have served as powerful incentives scientific collaboration. Methods— Cohorts Heart Aging Research Genomic Epidemiology Consortium was formed facilitate meta-analyses opportunities among multiple population-based...