Yueyin Pan
A5002727383- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Cancer therapeutics and mechanisms
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Advanced Chemical Sensor Technologies
- Monoclonal and Polyclonal Antibodies Research
Anhui Provincial Hospital
2017-2025
Sun Yat-sen University
2020-2025
University of Science and Technology of China
2018-2025
Xi’an Children’s Hospital
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Shanghai University of Medicine and Health Sciences
2025
Jiading District Central Hospital
2025
University of Southern California
2025
Chongqing Medical University
2025
Foshan Maternity and Child Health Care Hospital
2025
This article reports on a noninvasive approach in detecting and following-up individuals who are at-risk or have an existing COVID-19 infection, with potential ability to serve as epidemic control tool. The proposed method uses developed breath device composed of nanomaterial-based hybrid sensor array multiplexed detection capabilities that can detect disease-specific biomarkers from exhaled breath, thus enabling rapid accurate diagnosis. An exploratory clinical study this was examined...
To evaluate sintilimab versus placebo in combination with chemotherapy (cisplatin plus paclitaxel or cisplatin 5-fluorouracil) as first line treatment of unresectable locally advanced, recurrent, metastatic oesophageal squamous cell carcinoma.Multicentre, randomised, double blind, phase 3 trial.66 sites China and 13 outside between 14 December 2018 9 April 2021.659 adults (aged ≥18 years) advanced carcinoma who had not received systemic treatment.Participants were randomised 1:1 to receive...
Importance Programmed cell death ligand 1 inhibitors combined with chemotherapy has changed the approach to first-line treatment in patients extensive-stage small lung cancer (SCLC). It remained unknown whether adding a programmed (PD-1) inhibitor provided similar or better benefits SCLC, which would add evidence on efficacy of checkpoint SCLC. Objective To evaluate and adverse event profile PD-1 serplulimab plus compared placebo as Design, Setting, Participants This international,...
Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-negative metastatic breast cancer who had received prior chemotherapy for their disease. multicenter, open-label, single arm enrolled cancer, pretreated anthracycline, taxanes capecitabine, failed setting at least 1 most 4 regimens one endocrine drug hormone receptor-positive as well...
Importance Gastric and gastroesophageal junction cancers are diagnosed in more than 1 million people worldwide annually, few effective treatments available. Sintilimab, a recombinant human IgG4 monoclonal antibody that binds to programmed cell death (PD-1), combination with chemotherapy, has demonstrated promising efficacy. Objective To compare overall survival of patients unresectable locally advanced or metastatic gastric who were treated sintilimab chemotherapy vs placebo chemotherapy....
Cancer cells display phenotypic equilibrium between the stem-like and differentiated states during neoplastic homeostasis. The functional mechanistic implications of this subpopulation plasticity remain largely unknown. Herein, it is demonstrated that breast cancer stem cell (BCSC) secretome autonomously compresses population. Co-implantation with BCSCs decreases tumor-initiating capacity yet increases metastasis accompanying cells, wherein DKK1 identified as a pivotal factor secreted by for...
Importance The efficacy of niraparib maintenance therapy with an individualized starting dose (ISD) warrants further investigation in a broad population newly diagnosed advanced ovarian cancer (aOC), including patients without postoperative residual disease. Objective To evaluate the and safety ISD aOC (R0 resection permitted). Design, Setting, Participants This multicenter, randomized, double-blind, placebo-controlled, phase 3 study was conducted China enrolled 384 who received primary or...
Abstract Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but whether is also involved in metabolic reprogramming-mediated cancer progression remains unknown. Here, we report that directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH catalyzes interconversion between pyruvate lactate. Aurora-A-mediated phosphorylation LDHB serine 162 significantly increases its activity reducing to lactate, which...
Developing guidelines for the diagnosis and treatment of common cancers in China based on evidence-based practice, availability products, up-to-date advances precision medicine is one basic tasks Chinese Society Clinical Oncology (CSCO).In recent years, medical resources has become a major concern clinical guidelines, which particularly important developing countries or socioeconomically diverse territories.China world's largest country, with large territory uneven economic academic...