A5100588635- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Curcumin's Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Complex Systems and Time Series Analysis
- Lung Cancer Research Studies
- Natural product bioactivities and synthesis
- Ophthalmology and Eye Disorders
- Silymarin and Mushroom Poisoning
- Bioactive Compounds and Antitumor Agents
- Drug-Induced Hepatotoxicity and Protection
- Endoplasmic Reticulum Stress and Disease
- Satellite Communication Systems
- Cancer therapeutics and mechanisms
- Intensive Care Unit Cognitive Disorders
- Electric Power System Optimization
- Smart Grid and Power Systems
- Optical measurement and interference techniques
- Retinal Diseases and Treatments
- Climate Change Policy and Economics
- Ophthalmology and Visual Impairment Studies
- Pharmacological Effects of Natural Compounds
Chengdu University of Traditional Chinese Medicine
2024-2025
Wenzhou Medical University
2023-2024
First Affiliated Hospital of Wenzhou Medical University
2023-2024
North China Electric Power University
2023-2024
Dalian Medical University
2023
He Eye Hospital
2016
Second Artillery General Hospital of Chinese People's Liberation Army
2013
Ecological Consulting (Czechia)
2012
Walter de Gruyter (Germany)
2012
Chinese People's Armed Police Force
2008
Importance Programmed cell death ligand 1 inhibitors combined with chemotherapy has changed the approach to first-line treatment in patients extensive-stage small lung cancer (SCLC). It remained unknown whether adding a programmed (PD-1) inhibitor provided similar or better benefits SCLC, which would add evidence on efficacy of checkpoint SCLC. Objective To evaluate and adverse event profile PD-1 serplulimab plus compared placebo as Design, Setting, Participants This international,...
Neuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). It has been reported that TRIM45 associated with tumours and inflammatory diseases. However, the role in SAE relationship between are unknown. In this study, we found played regulating molecular mechanism.SAE was induced intraperitoneal injection LPS WT AAV-shTRIM45 mice. BV2 cells were treated LPS/ATP vitro. Cognitive function assessed Morris water maze. Nissl staining...
Diosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other plants. Diosmetin demonstrates variety of pharmacological activities, including anticancer, antioxidant, anti-inflammatory, antibacterial, metabolic regulation, cardiovascular function improvement, estrogenic effects, others. The process literature search was done using PubMed, Web Science ClinicalTrials databases with terms containing content, activity, pharmacokinetics, vivo, vitro. aim this...
Abstract Liver fibrosis, a progressive condition resulting from chronic liver injury, can lead to cirrhosis and hepatocellular carcinoma. Nanoparticles have emerged as promising tools for their diagnosis treatment due unique properties. This review highlights advances in lipid‐based (e.g., liposomes, solid lipid nanoparticles), polymer‐based nanocapsules, dendrimers), inorganic iron oxide, gold biological nanoparticles extracellular vesicles, exosomes). These enhance imaging contrast MRI CT,...
As a devastating neurological disease, spinal cord injury (SCI) results in severe tissue loss and dysfunction. Pregnane X receptor (PXR) is ligand-activated nuclear with major regulatory role xenobiotic endobiotic metabolism recently has been implicated the central nervous system. In present study, we aimed to investigate mechanism of PXR SCI.The clip-compressive SCI model was performed male wild-type C57BL/6 (PXR+/+ ) PXR-knockout (PXR-/- mice. The N2a H2 O2 -induced mimicked pathological...
Dichloroacetate (DCA), a pyruvate dehydrogenase kinase inhibitor, is often used to treat lactic acidosis and malignant tumors. Increasing studies have shown that DCA has neuroprotective effects. Here, we explored the role mechanism of in Sepsis associated encephalopathy (SAE). Single-cell analysis was determine important PDK4 SAE identify cell type. GO GSEA were correlation between pyroptosis. Through LPS + ATP stimulation, microglia pyroptosis model established observe expression level...
Background Sepsis-induced acute lung injury (ALI) is a common and serious complication of sepsis that eventually progresses to life-threatening hypoxemia. Disulfidptosis newly discovered type cell death associated with the pathogenesis different diseases. This study investigated potential association between sepsis-induced disulfidptosis by bioinformatics analysis. Methods In order identify differentially expressed genes (DEGs) linked sepsis, we screened appropriate data sets from GEO...
Against the backdrop of global climate change, China is actively promoting construction an ecological civilization and green low-carbon development, accounting treatment carbon emissions trading, as one important market mechanisms to achieve this goal, has become increasingly prominent. Although issued a number guidance documents on emission rights there are still challenges shortcomings, which limit accuracy comparability information affect participants' perception value rights. This paper...
The high proportion of renewable energy integration and the sharp fluctuation load bring huge backup demand to power system, which requires auxiliary service thermal units ensure safety system. However, widely used marginal price mechanism is difficult identify externalities value market members ancillary services provided by generators. To accurately externality members, Vickey-Clarke-Groves (VCG) based on incremental costs was introduced. Compared with mechanism, VCG removing generators...
In this paper we propose an M-ary MC CDMA scheme, which might be seen as a potential candidate for uplink mobile transmission. The provides variable data rates and high spectral efficiency in uplinks. transmitted bits are serial to parallel converted assigned number of groups. each group, several mapped certain frequency using modulation. Additionally, direct sequence spread spectrum modulation is used the transmission on chosen orthogonal frequency. groups user signals separated by...
Objective To detect the effects of cataract phacoemulsification,intraocular lens implantation and trabeculectomy for acute angle closure glaucoma (AACG).Methods 46 eyes with AACG were treated by trabeculectomy.Preoperative postoperative visual acuities,the depth anterior chamber,and intraocular pressure (IOP)of each eye recorded following-up ranged from 1 month to year.Results The acuities improved.The IOP in all was normal chamber improved.After surgery,39 had corneal edema; 11 uveal...
Abstract Background Neuroinflammation mediated by microglia pyroptosis activation is an important pathogenesis of septic encephalopathy(SAE). It reported that TRIM45 associated with tumors and inflammatory diseases. However, the role in SAE relationship between are unknown. In this study, we found plays regulating its molecular mechanism. Methods was induced lps mice transfected adenovirus shTRIM45. BV2 treated + ATP vitro. Cognitive function assessed Morris water maze. Nissl staining Tunnel...
Objective To investigate the safety and validity of fine adjusted-customized ablation treatment(F-CAT)for moderate high astigmatism.Methods 36patients(53 eyes)of astigmatism ranged from-2.00D to-6.00D(The mean cylindrical refraction were-2.65±0.93D) were treated with German Wavelight Allegretto wave Eye-Q bye means F-CAT.Results The uncorrected Visual acuity was 1.01±0.24 at 12 months after operation,48 eyes(90.6%)reached or exceeded pre-operation corrected visual acuity,the clearly amended...
Objective To observe the long-term efficacy of intravitreal injection Conbercept before trabeculectomy combined with panretinal photocoagulation (PRP) in treatment neovascular glaucoma (NVG). Methods The data 30 eyes NVG patients from Jan.2014 to Dec.2014 were collected and analyzed retrospectively. All cases treated Conbercerpt. After neovessels iris disappeared, they underwent PRP. The follow-up time was months. visual acuity, intraocular pressure, vessels complications observed...