A5100336638- Inflammasome and immune disorders
- Inflammatory Bowel Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
- Gut microbiota and health
- Genomics, phytochemicals, and oxidative stress
- Erythropoietin and Anemia Treatment
- Retinoids in leukemia and cellular processes
- IL-33, ST2, and ILC Pathways
- Estrogen and related hormone effects
- Algal biology and biofuel production
- Traditional Chinese Medicine Studies
- Ginseng Biological Effects and Applications
- Thermal Regulation in Medicine
- Kruppel-like factors research
- Glutathione Transferases and Polymorphisms
- Climate Change and Health Impacts
- Metabolomics and Mass Spectrometry Studies
- Biocrusts and Microbial Ecology
- Quantum Dots Synthesis And Properties
- S100 Proteins and Annexins
- Autoimmune and Inflammatory Disorders Research
- MRI in cancer diagnosis
- RNA and protein synthesis mechanisms
Wenzhou Medical University
2020-2023
First Affiliated Hospital of Wenzhou Medical University
2022-2023
Tohoku University
2021-2023
Tohoku Medical Megabank Organization
2023
Beijing University of Chinese Medicine
2023
State Key Laboratory of Oral Diseases
2020-2021
Yanshan University
2021
Sichuan University
2020-2021
Ningbo University
2020
Kagawa University
2020
Retinoids, particularly all- trans -retinoic acid (RA), are potent regulators of cell differentiation, proliferation, and apoptosis. The role -RA during development in the maintenance adult tissues has been well established. control levels cells is regulated by balance between its biosynthesis catabolism to inactive metabolites. cytochrome P450 enzyme P450RAI (herein renamed P450RAI-1) partially responsible for this inactivation -RA. In report, we describe identification, molecular cloning,...
Ulcerative colitis (UC) has become a global epidemic, and the lack of an effective cure highlights necessity urgency to explore novel therapies. Sijunzi Decoction (SJZD), classical Chinese herbal formula, been comprehensively applied clinically proven in treating UC; however, pharmacological mechanism behind its therapeutic benefits is largely obscure. Here, we find that SJZD can restore microbiota homeostasis intestinal barrier integrity DSS-induced colitis. significantly alleviated colonic...
Neuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). It has been reported that TRIM45 associated with tumours and inflammatory diseases. However, the role in SAE relationship between are unknown. In this study, we found played regulating molecular mechanism.SAE was induced intraperitoneal injection LPS WT AAV-shTRIM45 mice. BV2 cells were treated LPS/ATP vitro. Cognitive function assessed Morris water maze. Nissl staining...
While it is well established that the KEAP1-NRF2 pathway regulates main inducible cellular response to oxidative stress, this cytoprotective function of NRF2 could become deleterious host if confers survival onto irreparably damaged cells. In regard, we have found in diseased states, promotes transcriptional activation a specific subset senescence-associated secretory phenotype (SASP) gene program, which named NRF2-induced (NISP). two models hepatic disease using Pten::Keap1 and Keap1::Atg7...
Rheumatoid arthritis is a systemic autoimmune disease with pain and functional disorder of joints. Multiple strategies toward treatment the rheumatoid are operating, while there concerns serious adverse effects therapeutic drugs. Here, we show that activation Nrf2 (Nuclear factor erythroid 2-related 2) efficiently improves SKG mice, which develop T cell-mediated by zymosan A injection. We found genetic knockdown Keap1 (Kelch-like ECH-associated protein 1), negative regulator Nrf2, repressed...
ABSTRACTHeme oxygenase 1 (HO-1) is the key enzyme for heme catabolism and cytoprotection. Whereas HO-1 gene expression in response to various stresses has been investigated extensively, precise mechanisms by which regulated substrate remain elusive. To systematically examine whether stress-mediated induction substrate-mediated of utilize similar or distinct regulatory pathways, we developed an HO-1–DsRed-knock-in reporter mouse floxed loxP sites DsRed inserted. Myeloid lineage-specific...
The kidneys are the major organs for erythropoietin (EPO) production in adults, and thus, kidney damage results reduced EPO levels anemia. Inhibitors of Hypoxia-inducible factor-prolyl hydroxylase domain-containing protein (HIF-PHD) awaited as new therapeutic options renal It can be predicted that most patients who receive HIF-PHD inhibitors have dysfunction a cause Therefore, present study, we investigated effects inhibitor molidustat on anemia when initiated after onset Male C57BL/6J mice...
Abstract Csn2 is an important protein of the CRISPR‐Cas system. The physiological function this and its regulatory role in Streptococcus mutans , as primary causative agent human dental caries, still unclear. In study, we investigated whether csn2 deletion would affect S. physiology virulence gene expression. We used microscopic imaging, acid killing assays, pH drop, biofilm formation, exopolysaccharide (EPS) production tests to determine influenced colony morphology, tolerance/production,...
TGF-β is a critical cytokine to regulate multiple pathophysiological functions. For tumor development and progression, was reported play dual functions as suppressor epithelial-mesenchymal transition (EMT) inducer. The mechanism of the signaling pathway essential for TGF-β/Smad-targeted therapy in clinic. Here, ATBF1 demonstrated participate via different ways. On one hand, expression level associated with EMT migration induced by TGF-β. After treatment, reduced dose- time-dependent manner,...
Abstract Background Neuroinflammation mediated by microglia pyroptosis activation is an important pathogenesis of septic encephalopathy(SAE). It reported that TRIM45 associated with tumors and inflammatory diseases. However, the role in SAE relationship between are unknown. In this study, we found plays regulating its molecular mechanism. Methods was induced lps mice transfected adenovirus shTRIM45. BV2 treated + ATP vitro. Cognitive function assessed Morris water maze. Nissl staining Tunnel...
Objective: To establish a high performance liquid chromatography tandem mass spectrometry (HPLC / MS) method for the simultaneous determination of three antidepressant drugs in feces. Methods: Samples were pretreated with n-hexane isopropanol (95:5, v/v). Gradient elution was carried out mixed ultrapure water and acetonitrile as mobile phase separated by Agilent ZORBAX SB-C18 column (2.1 mm×100 mm, 3.5 m). The samples detected electrospray ionization quantified internal standard method....
Abstract Background: The pathophysiological mechanism of sepsis-related acute lung injury, which leads to a major cause mortality in critically ill patients remains ambiguous. Our previous study demonstrated that PICK1 played pivotal role regulating antioxidants (Glutathione) synthesis via affecting xCT, however, its effects on oxidants was still unknown. This aimed explore whether mediates reactive oxygen species release and apoptosis endotoxin-induced thereby funding effective treatments...
The Atlantic sea nettle (<i>Chrysaora quinquecirrha</i>) has been paid more and attention due to its high ecological value commercial cultivation. This study aimed evaluate that culture salinity levels affected on the growth digestive enzyme activities of <i>C. quinquecirrha</i>. Three (10‰, 20‰ 30‰) were used in cultured jellyfish at three stages scyphula, juvenile adult medusa. Results suggested had changed physiological performance...
To explore the differences in transcriptional levels between mutant strains of csn2 gene CRISPR-Cas9 system Streptococcus mutans( S. mutans) and wild-type strains.The mutans UA159, csn2-gene-deleted (Δ csn2) csn2-gene-covering csn2/pDL278- were cultivated. Total RNA was extracted, high-throughput sequencing technology used for transcriptome sequencing. Based on GO analysis KEGG differentially expressed genes, biological processes involved thoroughly examined. The qRT-PCR method to verify...