A5052240441- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare and Venom Research
- Anesthesia and Pain Management
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Inflammasome and immune disorders
- Nerve injury and regeneration
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Pain Management Techniques
- Hippo pathway signaling and YAP/TAZ
- Pain Management and Placebo Effect
- Sirtuins and Resveratrol in Medicine
- interferon and immune responses
- Intensive Care Unit Cognitive Disorders
- Biochemical effects in animals
- Anesthesia and Sedative Agents
- RNA Research and Splicing
- RNA modifications and cancer
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Shaanxi Research Association for Women and Family
2019
Second Affiliated Hospital of Zhejiang University
2019
Background: Although N 6 -methyladenosine (m A) plays a very important role in different biological processes, its function the brain has not been fully explored. Thus, we investigated roles of RNA demethylases Alkbh5/Fto cerebral ischemia-reperfusion injury. Methods: We used rat model and primary neuronal cell culture to study m A cortex ischemic penumbra after Alkbh5-shRNA Lv-Fto ( vitro) regulate expression their regulation Results: found that levels increased consecutive increase Alkbh5...
Cerebral ischemic stroke (IS) is still a difficult problem to be solved; energy metabolism failure one of the main factors causing mitochondrion dysfunction and oxidation stress damage within pathogenesis cerebral ischemia, which produces considerable reactive oxygen species (ROS) opens blood-brain barrier. Dichloroacetic acid (DCA) can inhibit pyruvate dehydrogenase kinase (PDK). Moreover, DCA has been indicated with capability increasing mitochondrial uptake promoting glucose in course...
Previous studies have demonstrated that cardiomyocyte apoptosis, ferroptosis, and inflammation participate in the progress of sepsis-induced cardiomyopathy (SIC). Although Islet cell autoantigen 69 (ICA69) is an imperative molecule could regulate immune response numerous illnesses, its function cardiovascular disease, particularly SIC, still elusive. We confirmed LPS significantly enhanced expression ICA69 wild-type (WT) mice, macrophages, cardiomyocytes. The knockout...
Abstract C‐Jun N‐terminal kinase (JNK) is a pivotal MAPK (mitogen‐activated protein kinase), which activated by ischemia brain injury and plays fairly crucial function in cerebral ischemic injury. Emerging studies demonstrated that JNK‐IN‐8 (a JNK inhibitor with high specificity) regulates traumatic through controlling neuronal apoptosis inflammation. However, the of stroke mechanisms underlying about neuroprotection are not well understood. In this work, male rats were treated after...
Electroacupuncture (EA) is commonly used to treat cerebrovascular diseases. This study aimed clarify the mechanisms of action treatments cerebral ischemic stroke from perspective gut microecology. We a mouse model and cell cultures investigate effects EA on intestinal microflora in mice models middle artery occlusion (MCAO) underlying antioxidant activities metabolites. Fecal microbiota transplantation (FMT) was validate roles microbiota. Metabolomic analysis performed characterize metabolic...
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine that ubiquitously distributed in the central and peripheral nervous systems. Moreover, its phosphorylated (P-CaMKII) involved memory, mood, pain regulation anterior cingulate cortex (ACC). Electroacupuncture (EA) traditional Chinese therapeutic technique can effectively treat chronic inflammatory pain. However, CaMKII-GluA1 role EA analgesia ACC remains unclear. This study investigated of P-CaMKII...
Neuropathic pain is a chronic condition caused by damage or dysfunction of the central peripheral nervous system. Electroacupuncture (EA) has an antinociceptive effect on neuropathic pain, which partially due to inhibiting astrocyte activation in spinal cord.We found that intrathecal injection 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), selective adenosine A1 receptor antagonist, reversed effects EA constriction injury-induced model.The expression GFAP L4-L6 cord was significantly upgraded,...
Objective . Our present study tested whether flurbiprofen axetil could reduce perioperative sufentanil consumption and provide postoperative analgesia with decrease in emergency agitation systemic proinflammatory cytokines release. Methods Ninety patients undergoing tangential excision surgery were randomly assigned to three groups: (1) preoperative dose of 100 mg a 2 μ g/kg 10 mL placebo by patient‐controlled (PCA) pump, (2) PCA (3) pump. Results Preoperative administration decreased...
Glioblastoma (GBM) ranks the most common and aggressive primary brain malignant tumor worldwide. However, survival rates of patients remain very poor. Therefore, molecular oncology GBM are urgently needed. In this study, we performed an integrative analysis DNA methylation gene expression to identify key epigenetic genes in GBM. The Cancer Genome Atlas (TCGA) database were downloaded. After data preprocessing, identified 4,881 differentially expressed (DEGs) between normal samples, including...
A previous study has demonstrated that pretreatment with electroacupuncture (EA) induces rapid tolerance to focal cerebral ischemia. In the present study, we investigated whether adenosine receptor 1 (A1 R) is involved in EA pretreatment-induced cognitive impairment after ischemia rats. Two hours pretreatment, was induced by middle artery occlusion for 120 min male Sprague-Dawley The neurobehavioral score, function [as determined Morris water maze (MWM) test], neuronal number, and Bax/Bcl-2...
This study was identified the risk factors for and designed to investigate influence of postoperative moderate-to-severe pain post anaesthesia care unit (PACU) in patients with malignancy.
Middle cerebral artery occlusion (MCAO) injury refers to impaired blood supply the brain that is caused by a cerebrovascular disease, resulting in local tissue ischemia, hypoxic necrosis, and rapid neurological impairment. Nevertheless, mechanisms involved are unclear, pharmacological interventions lacking. 25-Hydroxycholesterol (25-HC) was reported be cholesterol lipid metabolism as an oxysterol molecule. This study aimed determine whether 25-HC exerts protective effect on MCAO investigate...
The activation of adenosine A1 receptors is important for protecting against ischemic brain injury and pretreatment with electroacupuncture has been shown to mitigate insult. aim this study was test whether the receptor mediates pretreatment-induced neuroprotection injury. We first performed 30 minutes at Baihui acupoint (GV20), delivered a current 1 mA, frequency 2/15 Hz, depth mm. High-performance liquid chromatography found that triphosphate levels peaked in cerebral cortex 15 120 after...
The aim of the study was to role anterior cingulate cortex (ACC)-dorsal midbrain striatum (DMS) in neuropathic pain mice.Optogenetics has been increasingly used neuroscience research selectively and precisely control activity a defined group central neurons determine their roles behavioral functions animals. most important opsins are blue-sensitive ChR2 yellow-sensitive NpHR. Calcium-calmodulin dependent protein kinase Iiα (CaMKIIα) is mostly expressed pyramidal excitatory neurons. Mice were...
Limb ischemia/reperfusion (I/R) can induce inflammation, causing acute lung injury. The Toll‑like receptor 4 (TLR4)/NF‑κB pathway plays an important role in and chronic inflammatory disorders. Several studies have demonstrated the efficacy of acupuncture aim present study was to elucidate mechanism underlying protective effect electroacupuncture (EA) against injury induced by limb I/R. EA applied at Zusanli Sanyinjiao acupoints attenuated decreased secretion factors such as tumor necrosis...