A5101839146- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Prostate Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Esophageal and GI Pathology
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Cancer-related Molecular Pathways
- Management of metastatic bone disease
- Cancer Research and Treatments
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
Fujian Medical University
2011-2025
Xiamen University
2018-2025
Chinese People's Liberation Army
2022-2024
South China Agricultural University
2024
Weatherford College
2023
Fujian University of Traditional Chinese Medicine
2023
Huzhou University
2023
117th Hospital of People's Liberation Army
2022
Wuhan University of Technology
2021
Yueyang Hospital
2020
<h3>Importance</h3> Standard first-line therapy for advanced or metastatic esophageal carcinoma is chemotherapy, but the prognosis remains poor. Camrelizumab (an anti–programmed death receptor 1 [PD-1] antibody) showed antitumor activity in previously treated squamous cell carcinoma. <h3>Objective</h3> To evaluate efficacy and adverse events of camrelizumab plus chemotherapy vs placebo as a treatment <h3>Design, Setting, Participants</h3> This randomized, double-blind, placebo-controlled,...
Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), 514 patients with treatment-naïve ESCC were randomized (1:1) to receive toripalimab or placebo in combination paclitaxel plus cisplatin (TP) every weeks up 6 cycles, followed by maintenance. At prespecified final analysis of progression-free survival (PFS), a significant improvement PFS observed arm over (hazard ratio...
Background:The aim of the study was to assess role irradiation in expression HIF-1a, VEGF, and P53 human cervical carcinoma cells under a simulated hypoxia environment. Material andMethods:The tetrazolium-based colorimetric cellular assay (MTT) flow cytometry (FCM) were used detect growth inhibition rates HeLa different groups. Western blot reverse transcription polymerase chain reaction (RT-PCR) observe gene protein HIF-1α, P53. The effect HIF-1α on radioresistance VEGF confirmed with siRNA...
4000 Background: The current standard first-line therapy for advanced or metastatic ESCC is doublet chemotherapy, and prognosis remains poor. Camrelizumab, a humanized anti-PD-1 monoclonal antibody, has shown promising antitumor activity in previously treated (Huang et al. Lancet Oncol 2019). Immunotherapy may work synergistically with but lacking clinical evidences ESCC. Here, we report the findings of phase 3 ESCORT-1st study which evaluated efficacy safety camrelizumab plus chemotherapy...
Immune checkpoint inhibitors (ICIs) play an important role in the treatment of esophageal cancer (EC). However, their efficacy is variable, and there are still no effective convenient biomarkers to identify assess efficacy. In recent years, programmed cell death-ligand 1 (PD-L1) expression, tumor mutation burden (TMB) other commonly used cannot meet clinical needs. PNI easy obtain its predictive value for prognosis immunotherapy has been confirmed many species, but relationship between...
<title>Abstract</title> Background Patients with locally advanced esophageal squamous-cell carcinoma (LA-ESCC) generally experience poor prognosis after surgery. Neoadjuvant therapy has shown potential to improve survival outcomes. This study aimed compare the long-term efficacy and safety of neoadjuvant chemoimmunotherapy (nCIT) versus chemoradiotherapy (nCRT) in patients LA-ESCC. Methods multicenter included LA-ESCC treated at three hospitals China between November 2015 January 2024....
Esophageal squamous cell carcinoma (ESCC), the most common type of esophageal cancer, characterized by low five-year survival rate, and concurrent chemoradiotherapy (CCRT) has been proposed to treat ESCC, while potential biomarkers for prognostic monitoring after optimized CCRT remains unknown. Serum samples from 45 patients with ESCC were collected categorized into three groups: Control (pre-CCRT), (during CCRT), CCRT-1 M (one-month post-CCRT). The therapeutic effect was evaluated using CT...
Esophageal cancer (ESCA) poses a significant challenge in oncology because of the limited treatment options and poor prognosis. Therefore, enhancing therapeutic effects radiotherapy for ESCA identifying relevant targets are crucial improving both survival rate quality life patients. To define role transcription factor Snail family transcriptional repressor 1 (SNAI1) ESCA, particularly its regulation radiosensitivity. A comprehensive analysis TCGA data assessed SNAI1 expression ESCA. Survival...
Esophageal squamous cell carcinoma (ESCC) may be correlated with HPV infection, and the mechanism underlying ESCC formation induced by HPV16 infection remains elusive. Here, we overexpressed E6 E7 coordinated overexpression of these two genes in EPC2 cells. We found that expression promoted proliferation cells, upregulation shh was responsible for since use vismodegib led to failure organoid formation. Meanwhile, cells proliferation, migration, invasion vitro. Importantly, coordinately...
This study aims to investigate the impact of dietary supplementation with selenium yeast (SeY) and glycerol monolaurate (GML) on transfer antioxidative capacity between mother fetus during pregnancy its underlying mechanisms. A total 160 sows similar body weight parity 3–6 were randomly uniformly allocated four groups (n = 40) as follows: CON group, SeY GML SG (SeY + GML) group. Animal feeding started from 85th day gestation continued delivery. The resulted in increased placental reduced...
BACKGROUND:Different sensitivity of advanced cervical cancer to irradiation can decrease effectiveness radiotherapy in some cases. We attempted identify the differentially expressed genes residual after that might be associated with poor prognosis and radioresistance. MATERIAL AND METHODS:Differential expression was identified by an oligonucleotide microarray tissues before radiation a 50-Gy dose radiation. The results were validated quantitative real-time PCR. CXCL12 immunohistochemistry...
Background: Prostate cancer (PCa) is the second most common among men worldwide. Perineural invasion (PNI) was a prominent characteristic of PCa, which recognized as key factor in promoting PCa progression. As complex and heterogeneous disease, its true condition difficult to explain thoroughly with conventional bulk RNA sequencing. Thus, an improved understanding PNI-PCa progression at single-cell level needed. Methods: In this study, we performed scRNAseq on tumor tissues three patients....
The present study aimed to observe the role of mesenchymal stem cells (MSCs) in repair acute skin damage caused by radiation. Rat bone marrow MSCs (BMSCs) were isolated and cultured vitro. A rat model radiation‑induced was established irradiation hind legs Sprague-Dawley rats using a linear accelerator (45 Gy). After irradiation, randomly divided into two groups: BMSC group control group. Rats treated with tail vein injection 2x106 BMSCs (1 ml) immediately after local multipoint at injured...
Intestine derived lipopolysaccharide (LPS) is closely related to systemic inflammation and disorders, yet little known about its roles in the weanling stress of piglets potential as a nutritional intervention target. This study aimed investigate essential oils (EO) organic acids (OA) mitigating weaning by modulating circulation intestine LPS. Seventy-two weaned at 21 d old with body weight 8.12 ± 0.168 kg were randomly divided into control group (CON) an experimental group, each consisting...
Fuel cell power generation system is a potential renewable source. To reduce hydrogen consumption and enhance the dynamic performance of system, Grey–Markov chain prediction energy management strategy for fuel systems was proposed. Firstly, topology proposed, mathematical model established through mechanism analysis. Secondly, framework presented, proposed to predict load based on which implemented. Finally, compared with rule-based by experiment. The results show that can accurately in...
CCK-8, Cell Counting Kit 8; Chip, Chromatin Immunoprecipitation; EC, Esophageal cancer; EMT, epithelial-to-mesenchymal transition; ESCC, squamous cell carcinomas; LLGL2, lethal (2) giant larvae protein homolog 2; LLGL2ov, LLGL2 overexpression; MET, mesenchymal-epithelial miRNAs, MicroRNAs; PRM-MS, Parallel reaction monitoring-Mass spectrometry; SD, Standard deviation; SOX, sex determining region Y (SRY)-like box; SOX2-Kd, SOX2-knockdwon; TUNEL, TdT-mediated dUTP Nick-End Labeling.
Microalgae play an important role in the formation of biofloc. To demonstrate feasibility Chlorella pyrenoidosa biofloc formation, experiment was performed with a simple random design consisting five inoculation levels (in triplicate) C. (0, 1 × 108, 109, 5 and 1010 cells·L−1) system. All treatments kept C:N ratio approximately 15:1. This study observed effects different initial concentrations on water quality bacterial community systems. The results indicated that had ability to enhance...