A5100342869- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Consumer Market Behavior and Pricing
- Enzyme Production and Characterization
- Supramolecular Self-Assembly in Materials
- Biofuel production and bioconversion
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Angiogenesis and VEGF in Cancer
- DNA Repair Mechanisms
- Digital Platforms and Economics
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Hepatitis C virus research
- Enhanced Oil Recovery Techniques
- Nanofabrication and Lithography Techniques
Beijing Ditan Hospital
2024-2025
Capital Medical University
2023-2025
Sinopec (China)
2023-2025
Capital University
2025
Nanjing Agricultural University
2022-2025
Sanya University
2024-2025
Northwestern Polytechnical University
2020-2025
Henan University of Technology
2025
Beijing University of Chinese Medicine
2019-2025
Sun Yat-sen University
2014-2025
A kind of highly sensitive bifunctional sensing hydrogel composed dense and small-size AgNP modified carbon nanotubes was studied, its application in underwater water pressure temperature detection demonstrated.
Resident cardiac fibroblasts (CFs) play crucial roles in sensing injury signals and regulating inflammatory responses post-myocardial infarction (MI). Damaged mitochondria can be transferred extracellularly via various mechanisms, including extracellular vesicles (EVs). In this study, we aimed to investigate whether CFs could transfer damaged mitochondrial components small EVs (sEVs) elucidate their role post-MI. Left anterior descending coronary artery ligation was performed mice....
Progressive tissue fibrosis is a cause of major morbidity and mortality. Pulmonary an epithelial-mesenchymal disorder in which TGF-β1 plays central role pathogenesis. Here we show that follistatin-like 1 (FSTL1) differentially regulates TGF-β bone morphogenetic protein signaling, leading to epithelial injury fibroblast activation. Haplodeletion Fstl1 mice or blockage FSTL1 with neutralizing antibody reduced bleomycin-induced vivo. induced response lung promotes the accumulation...
Rationale: Anti-tumor necrosis factor (TNF) therapy is a very effective way to treat inflammatory bowel disease. However, systemic exposure anti-TNF-α antibodies through current clinical administration can cause serious adverse effects in many patients. Here, we report facile prepared self-assembled supramolecular nanoparticle based on natural polyphenol tannic acid and poly(ethylene glycol) containing polymer for oral antibody delivery. Method: This was fabricated within minutes aqueous...
Abstract Here, a novel strategy to selectively degrade membrane proteins of programmed cell death‐ligand 1 (PD‐L1) in cancer cells is reported. 4T1 show high levels extracellular alkaline phosphatase (ALP) and PD‐L1. Therefore, peptide derivatives capable responding ALP binding PD‐L1 are designed. Enzyme‐instructed self‐assembly (EISA) by surface‐induced Comp. 3 leads the selective formation nanomaterials around on membrane, which similar attaching hydrophobic label surface simulate its...
We report a versatile mechanophore exhibiting vividly detectable, light-regulable multicolor mechanochromism. Such optical features rely on the synergistic coupling of mechanochromic bis-rhodamine (Rh) and photochromic bisthienylethene (BTE). Poly(methyl acrylate)s incorporating this bis-mechanophore can be mechanically activated under sonication. The relative distribution two distinctly colored fluorescent Rh ring-opening products is altered with different magnitudes applied force....
RNA modifications play a pivotal role in regulating cellular biology by exerting influence over distribution features and molecular functions at the post-transcriptional level.Among these modifications, N7-methylguanosine (m7G) stands out as one of most prevalent.Over recent years, significant attention has been directed towards understanding implications m7G modification.This modification is present diverse molecules, including transfer RNAs, messenger ribosomal other noncoding RNAs.Its...
With continued water injection development, most oilfields have entered high and ultra-high water-cut stages. To address the issue of poor thermal salt resistance in conventional polymer flooding systems, a salt-tolerant amphiphilic polymer-based supramolecular inclusion system was developed, incorporating surfactant as synergistic agent to reduce oil–water interfacial tension (IFT) further increase viscosity. In this study, viscosity were used evaluation indicators optimize formulation...
Sox2 and Oct4 are transcription factors with the characteristics of regulating self-renewal differentiation embryonic stem cell. The aim this study was to detect expression analyze their clinical significance in human non-small-cell lung cancer (NSCLC). Expression were assayed tissues corresponding paracancerous from 44 patients NSCLC 21 benign tumors using immunohistochemistry, Western blot, reverse polymerase chain reaction (RT-PCR). correlation between tumor type, grade prognosis utility...
Aims: Sweroside, a secoiridoid glucoside extracted from Swertia pseudochinensis Hara, is reported to possess antioxidant and anti-inflammatory activities. However, whether sweroside has protective effect on myocardial ischemia–reperfusion (IR) injury yet be elucidated. The present study aimed confirm the cardioprotective of identify its underlying mechanism. Methods Results: H9c2 cells were pretreated with then underwent hypoxia–reoxygenation. Cell Counting Kit-8, creatine kinase-myocardial...
Neuroprotection in cerebral ischemia (CI) has received increasing attention. However, efficient delivery of therapeutic agents to the brain remains a major challenge due complex environment brain. Nose-to-brain-based is promising approach. Here, we optimized nanocarrier formulation neuroprotective that can be used for nose-to-brain by obtaining RVG29 peptide-modified polyethylene glycol-polylactic acid-co-glycolic acid nanoparticles (PEG-PLGA RNPs) have physicochemical properties lead stable...
Rationale: Macrophages play multi-dimensional roles in hepatic fibrosis.Studies have implicated Notch signaling mediated by the transcription factor RBP-J macrophage activation and plasticity.Additionally, we previously shown that myeloid-specific disruption of can ameliorate fibrosis mice.Accordingly, next asked whether blocking macrophages could serve as a therapeutic strategy to treat fibrosis.In this study, used combination decoy oligodeoxynucleotides (ODNs) exosomes test...