A5100765398- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cutaneous Melanoma Detection and Management
- Breast Cancer Treatment Studies
- Eosinophilic Esophagitis
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Angiogenesis and VEGF in Cancer
- Lymphatic System and Diseases
- CAR-T cell therapy research
- Lipid metabolism and disorders
- Cancer, Stress, Anesthesia, and Immune Response
- COVID-19 Clinical Research Studies
- Plasma Applications and Diagnostics
- interferon and immune responses
- Plant biochemistry and biosynthesis
- Microbial Inactivation Methods
- Immunotherapy and Immune Responses
- Polyamine Metabolism and Applications
Hubei University of Technology
2024-2025
Jilin University
2023-2025
First Hospital of Jilin University
2025
Zhongshan Hospital
2022-2024
First Affiliated Hospital of Xiamen University
2023-2024
Xiamen University
2024
Texas A&M University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking Union Medical College Hospital
2022-2024
Fudan University
2022-2024
Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 is a virus-induced inflammatory disease of the airways and lungs that leads to multi-organ damage death. Here we show cellular lipid synthesis required for SARS-CoV-2 replication offers an opportunity pharmacological intervention. Screening short-hairpin RNA sublibrary targets metabolic genes, identified genes either inhibit or promote viral infection, including two key candidate ACACA FASN, which operate in...
The incidence of hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is increasing. Plasmapheresis theoretically effective in removing triglyceride from plasma, but whether it confers clinical benefits unclear.To assess the association between plasmapheresis and duration organ failure among patients with HTG-AP.This an a priori analysis data multicenter, prospective cohort study enrolled 28 sites across China. Patients HTG-AP were admitted within 72 hours disease onset. first patient...
Cereal and legume proteins, pivotal for human health, significantly influence the quality stability of processed foods. Despite their importance, inherent limited functional properties these natural proteins constrain utility across various sectors, including food, packaging, pharmaceutical industries. Enhancing attributes cereal through scientific technological interventions is essential to broadening application. Cold plasma (CP) technology, characterized by its non-toxic, non-thermal...
Background As an integral part of the tumor microenvironment (TME), tumor-associated neutrophils play a crucial role in development. The objective this study was to investigate plasticity N1 and N2 TME pancreatic ductal adenocarcinoma (PDAC), along with its impact on survival association immune infiltrations. Methods primary validation cohorts including 90 radical resection patients from September 2012 May 2016 29 2018 October 2019, respectively, complete data, were enrolled....
Abstract The cGAS-STING signaling pathway has emerged as a promising target for immunotherapy development. Here, we introduce light-sensitive optogenetic device control of the cGAS/STING to conditionally modulate innate immunity, called ‘light-inducible SMOC-like repeats’ (LiSmore). We demonstrate that photo-activated LiSmore boosts dendritic cell (DC) maturation and antigen presentation with high spatiotemporal precision. This non-invasive approach photo-sensitizes cytotoxic T lymphocytes...
No specific triglyceride-lowering therapy is recommended in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP), primarily because of the lack quality evidence. This study aimed to describe practice variations therapies for early HTG-AP and assess whether more rapid triglyceride decline associated improving organ failure. a multicentre, prospective cohort recruiting elevated plasma (> 11.3 mmol/L) admitted within 72 h from onset symptoms. Patients were dichotomised on...
The role of CD161 expression on CD8+ T cells in tumor immunology has been explored a few studies, and the clinical significance CD161+CD8+ pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study seeks to clarify prognostic value molecular characteristics linked cell infiltration PDAC. included 186 patients with confirmed PDAC histology after radical resection. was assessed using immunofluorescence staining microarrays. Flow cytometry single-cell RNA sequencing were used evaluate...
Abstract Introduction Demyelination is a key factor in axonal degeneration and neural loss, leading to disability multiple sclerosis (MS) patients. Transforming growth beta activated kinase 1 (TAK1) critical molecule involved immune inflammatory signaling pathways. Knockout of microglia TAK1 can inhibit autoimmune inflammation the brain spinal cord improve outcome MS. However, it unclear whether inhibiting alleviate demyelination. Methods Eight‐week‐old male c57bl/6j mice were randomly...
Tyrosol is an important drug precursor, and Saccharomyces cerevisiae one of the main microorganisms that produces tyrosol. Although excessive metabolic modification increases production tyrosol, it also causes a decrease in growth rate yeast. Therefore, this study attempted to restore S. through adaptive evolution further improve tyrosol production. After laboratory S26, three evolutionary strains were obtained. The biomass strain S26-AE2 reached 17.82 g DCW/L presence 100 g/L glucose, which...
Pancreatic ductal adenocarcinoma (PDAC) has been widely considered as one of the most lethal malignancies with a 5-year overall survival (OS) rate only 11%.1 Lots efforts have devoted into its early diagnosis, treatment strategies, and pathogenesis, etc. PDAC is characterized excessive desmoplastic tumor abundant immune cells infiltration, mainly including macrophages, T cells, immature myeloid neutrophils. Neutrophils are white blood in regarded homogeneous group past, which belongs to...
Background: Prostate cancer (PCa) is the second most common among men worldwide. Perineural invasion (PNI) was a prominent characteristic of PCa, which recognized as key factor in promoting PCa progression. As complex and heterogeneous disease, its true condition difficult to explain thoroughly with conventional bulk RNA sequencing. Thus, an improved understanding PNI-PCa progression at single-cell level needed. Methods: In this study, we performed scRNAseq on tumor tissues three patients....
Background: Patients with pancreatic ductal adenocarcinoma (PDAC) are increasingly receiving systemic neoadjuvant chemotherapy (NAC), particularly those borderline resectable and locally advanced disease. However, the specific role of additional adjuvant (AC) in these patients is unknown. The objective this study to further assess clinical benefit impact AC resected PDAC after NAC. Methods: Data on or without following NAC surgical resection were retrospectively retrieved from Surveillance,...
The limited availability of high-cost nucleotide sugars is a significant constraint on the application their downstream products (glycosides and prebiotics) in food or pharmaceutical industry. To better solve problem, this study presented one-pot approach for biosynthesis UDP-Gal using thermophilic multienzyme system consisting GalK, UGPase, PPase. Under optimal conditions, 2 h reaction resulted UTP conversion rate 87.4%. In fed-batch with Gal/ATP = 20 mM:10 mM, accumulated to 33.76 mM...
Abstract Background Preventing breast cancer-related lymphedema (BCRL) by preserving upper lymphatic drainage is still controversial. Our study aimed to use the axillary reverse mapping (ARM) technique in patients who underwent surgery analyse correlation between postoperative residual ARM nodes and occurrence of lymphedema, select candidates at high risk developing oncologic safety nodes. Methods Patients undergoing sentinel lymph node biopsy (SLNB) or dissection (ALND) from October 2015...
Colorectal cancer (CRC) is a prevalent malignancy with diverse molecular characteristics. The NGS-based approach enhances our comprehension of genomic landscape CRC and may guide future advancements in precision oncology for patients.In this research, we conducted an analysis using Next-Generation Sequencing (NGS) on samples collected from 111 individuals who had been diagnosed CRC. We identified somatic germline mutations structural variants across the tumor genomes through comprehensive...
Abstract Background Hexokinase (HK) is the first rate‐limiting enzyme of glycolysis, which can convert glucose to glucose‐6‐phosphate. There are several subtypes HK, including HK2, highly expressed in a variety different tumors and closely associated with survival. Methods Non‐small cell lung cancer (NSCLC) A549 cells stable overexpression knockdown HK2 were obtained by lentivirus transfection. The effects on proliferation, migration, invasion, glycolytic activity investigated. apoptosis...