A5053958827- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Wound Healing and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Obstructive Sleep Apnea Research
Zhongshan Hospital
2017-2025
Fudan University
2017-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2020-2025
Sun Yat-sen University
2017-2025
The First Affiliated Hospital, Sun Yat-sen University
2017-2025
Shaanxi Normal University
2025
Lanzhou University
2024
Temper (United States)
2024
First Hospital of Lanzhou University
2024
Robert Bosch (Germany)
2024
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, necessitating approaches to improve prognosis. As the mediator of allergic process, mast cells have been found in various cancers and are associated with survival. However, biological behaviors tumor‐associated (TAMCs) remain unclear. Herein, an excessive infiltration TAMCs PDAC demonstrated, which apparently poor survival patients. recruit CXCR2 + MCs into TME, then inhibited ferroptosis, maintained their...
Alteration of the lung microbiome has been observed in several respiratory tract diseases. However, most previous studies were based on 16S ribosomal RNA and shotgun metagenome sequencing; viability functional activity microbiome, as well its interaction with host immune systems, have not studied. To characterize active associations response clinical features, we applied metatranscriptome sequencing to bronchoalveolar lavage fluid (BALF) samples from 25 patients chronic obstructive pulmonary...
Abstract CD73 is a glycosylphosphatidylinositol (GPI)‐anchored protein that attenuates tumour immunity via cooperating with CD39 to generate immunosuppressive adenosine. Therefore, blockade has been incorporated into clinical trials for cancers based on preclinical efficacy. However, the biological role and underlying mechanism of in pancreatic cancer (PC) microenvironment its prognostic impact have not comprehensively studied. In this article, we found expression was up‐regulated PC tissues...
This study aimed to determine whether community-acquired pneumonia (CAP) had a metabolic profile and this can be used for disease severity assessment. A total of 175 individuals including 119 CAP patients 56 controls were enrolled divided into two cohorts. Serum samples from discovery cohort (n = 102, 38 non-severe CAP, 30 severe 34 age sex-matched controls) determined by untargeted ultra-high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based metabolomics....
Abstract Lipopolysaccharide (LPS) as an important inflammatory mediator activates the innate/adaptive immune system. The existence of LPS in pancreatic ductal adenocarcinoma (PDAC) has been reported, however, its biological function PDAC remains unclear. Here, we demonstrated that circulating and tumoral was significantly increased by intestinal leakage orthotopic murine model, administration promoted T cell infiltration but exhaustion paradoxically subcutaneous model. By bioinformatic...
Background As an integral part of the tumor microenvironment (TME), tumor-associated neutrophils play a crucial role in development. The objective this study was to investigate plasticity N1 and N2 TME pancreatic ductal adenocarcinoma (PDAC), along with its impact on survival association immune infiltrations. Methods primary validation cohorts including 90 radical resection patients from September 2012 May 2016 29 2018 October 2019, respectively, complete data, were enrolled....
Background: The prognosis of pancreatic carcinoma (PC) remains poor and the American Joint Committee on Cancer (AJCC) 8th staging system for survival prediction in PC patients after curative resection is still limited. Thus, aim this study to refine a valuable prognostic model novel with resection. Methods: data 3,458 used were retrieved from Surveillance, Epidemiology, End Results database registry National Institute. value lymph node ratio (LNR) was analyzed primary cohort nomogram based...
Background:The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor and the models for survival prediction in PDAC patients after curative resection are still limited.Preoperative alkaline phosphatase-to-albumin ratio (APAR), an original inflammation-based score, has been established to analyze prognostic significance PDAC.Therefore, this study, we aim formulate a valuable nomogram following resection.Methods: A total 354 with undergoing were retrospectively enrolled study.The...
To evaluate somatic mutations, circulating tumor cells (CTCs) and DNA (ctDNA) in patients with Pancreatic ductal adenocarcinoma (PDAC) pathologic complete response (pCR) to neoadjuvant therapy (NAT) find their associations outcome.Thirty-six PDAC pCR were identified from 2009 2017. Macrodissection was performed on resected specimens isolate 332 regions of interest including fibrosis, normal duct, parenchyma, undefined (UDCs). Cell-free CTCs also extracted. Next-generation sequencing used...
The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome 2 (SARS-CoV-2). objective of this study was to determine clinical course and risk factors for patients showing recurrent SARS-CoV-2 RNA positivity. A total 1087 COVID-19 confirmed RT-PCR from February 24, 2020 March 31, were retrospectively enrolled. Advanced age significantly associated with mortality. In addition, 81 (7.6%) discharged tested positive during isolation period. For positivity,...
The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor due to the difficulty disease diagnosis and therapy. Immunotherapy has had robust performance against several malignancies, including PDAC. In this study, we aim analyze expression CD8 FoxP3 on T lymphocytes TGF-β in tumor tissues, then possible clinical significance these finding order find a novel effective immunotherapy target PDAC using murine model. A tissue microarray patient samples was stained analyzed for...
Objective: The aim of this study was to characterize the patterns and treatment disease recurrence in patients achieving a pathological complete response (pCR) following neoadjuvant chemoradiation for advanced pancreatic ductal adenocarcinoma (PDAC). Summary Background Data: A pCR is an independent predictor improved survival PDAC. However, still observed these patients. Methods: Patients with PDAC who were treated therapy had identified between 2009 2017. Overall (OS) determined from...
The role of CD161 expression on CD8+ T cells in tumor immunology has been explored a few studies, and the clinical significance CD161+CD8+ pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study seeks to clarify prognostic value molecular characteristics linked cell infiltration PDAC. included 186 patients with confirmed PDAC histology after radical resection. was assessed using immunofluorescence staining microarrays. Flow cytometry single-cell RNA sequencing were used evaluate...
Community-acquired pneumonia (CAP) is a major cause of death worldwide and occurs with variable severity. There are few studies focused on the expression soluble urokinase-type plasminogen activator receptor (suPAR) syndecan-4 in patients CAP. A prospective, multi-centre study was conducted between January 2014 December 2016. total 103 severe CAP (SCAP), 149 non-SCAP, 30 healthy individuals were enrolled. Clinical data recorded for all enrolled patients. Serum suPAR levels determined by...
The aims of this study were to introduce our experience with treating patients pancreatic solid pseudopapillary tumors (SPTs) and investigate the clinical risk factors for recurrence SPTs because no consensus has been established date.One hundred twenty-one underwent surgical resection from January 2008 December 2015 in institution. Clinical data collected standardized reports.Of 121 patients, 93 (76.9%) women, 28 (23.1%) men, mean age at diagnosis was 33.7 years (range, 11-68 years). Sixty...
Abstract Pancreatic ductal adenocarcinoma is the known kind of tumor biologically featured as high malignant degree, lack effective methods for diagnosis and treatment, which reflects its unpleasant prognosis. Recently, with breakthrough burgeoning therapeutic methods, flush dawn pancreatic cancer nearly arrives. Nowadays, besides surgery, neoadjuvant chemoradiotherapy, vaccine therapy, immunotherapy all show their active situation obtain certain clinical efficacy, but that still limited to...
Background: The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains dismally poor and is widely considered as an intricate genetic disorder. mutational landscape PDAC may directly reflect cancer immunogenicity dictate the extent phenotype immune cell infiltration. In adverse, microenvironment also effect gene expression cells, which associated with clinical prognosis. Thus, it crucial to identify genomic alterations in its impacts on Methods: profiles, mutation data information 179...
Derivates of natural products have been wildly utilized in the treatment malignant tumors. Isorhamnetin (ISO), a most important active ingredient derived from flavonoids, shows great potential tumor therapy. However, therapeutic effects ISO on gastric cancer (GC) remain unclear. Here, we demonstrate that dramatically inhibited proliferation two types GC cells (AGS-1 and HGC-27) both vitro vivo time- dose-dependent manners. These results are consistent with transcriptomic analysis ISO-treated...