A5014748431- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Renal cell carcinoma treatment
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Transplantation: Methods and Outcomes
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Organ Transplantation Techniques and Outcomes
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Frailty in Older Adults
Northwell Health
2019-2025
Hofstra University
2021-2025
Johns Hopkins Hospital
2015-2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2020-2024
Canadian Blood Services
2024
The Ohio State University Wexner Medical Center
2020-2023
Erasmus University Rotterdam
2023
Hôpital Beaujon
2023
Assistance Publique – Hôpitaux de Paris
2023
University of Virginia
1995-2023
Objective: To describe accurately the pattern, timing, and predictors of disease recurrence after a potentially curative resection for pancreatic ductal adenocarcinoma (PDAC). Summary Background Data: After surgery PDAC, most patients will develop recurrence. Understanding patterns timing failure can help guide improvements in therapy. Methods: Patients who underwent pancreatectomy PDAC at Johns Hopkins Hospital between 2000 2010 were included. Exclusion criteria incomplete follow-up...
Significance Few patients with pancreatic cancer survive longer than 5 y, in part because most are identified only after their disease has progressed to an advanced stage. In this study, we show how combining mutations circulating tumor DNA (ctDNA) protein markers can result a screening test improved sensitivity while retaining specificity. The combination of the ctDNA and was superior any single marker. Moreover, detected nearly two-thirds cancers that had no evidence distant metastasis at...
Objective: The aim of this study was to evaluate and validate the proposed 8th edition American Joint Committee on Cancer (AJCC) system for T N staging pancreatic adenocarcinoma. Summary Background Data: Investigators have questioned clinical relevance reproducibility previous AJCC Methods: Prospective databases at Memorial Sloan Kettering (MSK), Massachusetts General Hospital (MGH), Johns Hopkins (JHH) were queried patients who had undergone resection Patients underwent a margin-negative...
Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and are well documented in families which multiple members have had cancer. Methods To define the prevalence of these patients with apparently sporadic cancer, we sequenced 32 genes, including known DNA prepared from normal tissue obtained 854 ductal adenocarcinoma, 288 other periampullary neoplasms, 51 non-neoplastic diseases who underwent resection at Johns Hopkins Hospital between 2000 2015. Results...
The aim of the study was to identify survival patients with locally advanced pancreatic cancer (LAPC) and assess effect surgical resection after neoadjuvant therapy on patient outcomes.An increasing number LAPC who respond favorably undergo resection. impact surgery is largely unknown.All presented institutional multidisciplinary clinic (PMDC) from January 2013 September 2017 were included in study. Demographics clinical data treatment documented. Primary tumor rates overall (OS) primary...
To establish an evidence-based cut-off to differentiate between early and late recurrence compare clinicopathologic risk factors the two groups.A clear definition of "early recurrence" after pancreatic ductal adenocarcinoma resection is currently lacking.Patients undergoing pancreatectomy for 2000 2013 were included. Exclusion criteria neoadjuvant therapy incomplete follow-up. A minimum P-value approach was used evaluate optimal value recurrence-free survival divide patients into cohorts...
The objective of this study was to investigate the characteristics, treatment and prognosis early versus late recurrence intrahepatic cholangiocarcinoma (ICC) after hepatic resection.Patients who underwent resection with curative intent for ICC were identified from a multi-institutional database. Data on clinicopathological initial operative details, timing sites recurrence, management long-term outcomes analysed.A total 933 patients included. With median follow-up 22 months, 685 (73·4 per...
Composite measures may be superior to individual for the analysis of hospital performance and quality surgical care.To determine incidence a so-called textbook outcome, composite measure care, among patients undergoing curative-intent resection intrahepatic cholangiocarcinoma.This cohort study involved an multinational, multi-institutional patient from 15 major hepatobiliary centers in North America, Europe, Australia, Asia who underwent cholangiocarcinoma between 1993 2015. Data was...
Liver cancer is the fourth leading cause of cancer-related mortality and distinguished by a relative paucity chemotherapy options. It has been hypothesized that intratumor genetic heterogeneity may contribute to high failure rate chemotherapy. Here, we evaluated functional in cohort primary human liver organoid lines. Each surgical specimen was used generate multiple lines, obtained from distinct regions tumor. A total 27 lines were established tested with 129 drugs, generating 3,483 cell...
BRAF mutations are reportedly associated with aggressive tumor biology. However, in contrast primary colorectal cancer, the association of V600E and non-V600E survival recurrence after resection liver metastases (CRLM) has not been well studied.To investigate prognostic independently compared other determinants, such as KRAS mutations.In this cohort study, all patients who underwent for CRLM curative intent from January 1, 2000, through December 31, 2016, at institutions participating...
Although surgery offers the best chance of a potential cure for patients with localized, resectable intrahepatic cholangiocarcinoma (ICC), prognosis remains dismal largely because high incidence recurrence.To predict very early recurrence (VER) (ie, within 6 months after surgery) following resection ICC in pre- and postoperative setting.Patients who underwent curative-intent between May 1990 July 2016 were identified from an international multi-institutional database. The study was conducted...
To describe the survival outcome of patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma (BR/LA-PDAC) who have a pathologic complete response (pCR) following neoadjuvant chemoradiation.Patients BR/LA-PDAC are often treated chemoradiation in an attempt to downstage tumor. Uncommonly, pCR may result.A retrospective review prospectively maintained database was performed at single institution. defined as no viable tumor identified pancreas lymph nodes by...
In research settings, circulating tumor DNA (ctDNA) shows promise as a tumor-specific biomarker for pancreatic ductal adenocarcinoma (PDAC). This study aims to perform analytical and clinical validation of KRAS ctDNA assay in Clinical Laboratory Improvement Amendments (CLIA) College American Pathology-certified laboratory.Digital-droplet PCR was used detect the major PDAC-associated somatic mutations (G12D, G12V, G12R, Q61H) liquid biopsies. For validation, 290 preoperative longitudinal...
Abstract Introduction While postoperative adjuvant chemotherapy (AC) is generally recommended for intrahepatic cholangiocarcinoma (ICC), its benefit remains debated. This study aimed to identify patients that may from AC following liver resection of ICC. Methods Patients who underwent ICC between 2000 and 2023 were identified an international multi-institutional database. Individual multivariable Cox models used evaluate the interaction each prognostic factor effect on survival. Results...