Giuseppe Malleo
A5025062457- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- COVID-19 and healthcare impacts
- Nutrition and Health in Aging
- Neuroblastoma Research and Treatments
- Colorectal Cancer Surgical Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic and Kidney Cyst Diseases
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Surgical site infection prevention
- Epigenetics and DNA Methylation
University of Verona
2016-2025
Fondazione Poliambulanza Istituto Ospedaliero
2024
Yahoo (United Kingdom)
2024
Barro Colorado Island
2024
General Motors (India)
2024
Flinders Medical Centre
2024
Flinders University
2024
Royal Free London NHS Foundation Trust
2024
Aquinas Institute of Theology
2023
Pancreas Centre (Canada)
2016-2023
The role of surgically placed intra-abdominal drainages after pancreatic resections has not been clearly established. In particular, their effect on morbidity rates and the optimal timing for removal remains controversial.A total 114 eligible patients who underwent standard at low risk postoperative fistula according to our institutional protocol (amylase value in drains < or =5000 U/L day [POD] 1) were randomized POD 3 receive either early (POD 3) drain 5 beyond). primary end point study...
Intraductal neoplasms are important precursors to invasive pancreatic cancer and provide an opportunity detect treat neoplasia before carcinoma develops. The diagnostic evaluation of these lesions is challenging, as imaging cytological sampling do not accurate information on lesion classification, the grade dysplasia or presence invasion. Moreover, molecular driver gene mutations precursor have yet be fully characterized. Fifty-two intraductal papillary neoplasms, including 48 mucinous...
<h3>Objectives</h3> Serous cystic neoplasm (SCN) is a of the pancreas whose natural history poorly known. The purpose study was to attempt describe SCN, including specific mortality. <h3>Design</h3> Retrospective multinational SCN diagnosed between 1990 and 2014. <h3>Results</h3> 2622 patients were included. Seventy-four per cent women, median age at diagnosis 58 years (16–99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus...
<h3>Importance</h3> The recently released eighth edition of the American Joint Committee on Cancer TNM staging system for pancreatic cancer seeks to improve prognostic accuracy but lacks international validation. <h3>Objective</h3> To validate in an cohort patients with resected ductal adenocarcinoma. <h3>Design, Setting, and Participants</h3> This multicenter study took place 5 tertiary centers Europe United States from 2000 2015. Patients who underwent pancreatoduodenectomy nonmetastatic...
There are no established guidelines for pathologic diagnosis/reporting of intraductal papillary mucinous neoplasms (IPMNs).
Objective: To use the concept of benchmarking to establish robust and standardized outcome references after pancreatico-duodenectomy (PD). Background: Best achievable results PD are unknown. Consequently, comparisons among different cohorts, centers or with novel surgical techniques remain speculative. Methods: This multicenter study analyzes consecutive patients (2012–2015) undergoing in 23 international expert pancreas surgery. Outcomes without significant comorbidities major vascular...
Objective To evaluate mid-term outcomes and predictors of survival in non-operated patients with pancreatic intraductal papillary mucinous neoplasms (IPMNs) worrisome features or high-risk stigmata as defined by International Consensus Guidelines for IPMN. Reasons non-surgical options were physicians’ recommendation, patient personal choice comorbidities precluding surgery. Methods In this retrospective, multicentre analysis, IPMNs classified branch duct (BD) main (MD), the latter including...
// Michele Simbolo 1,2,* , Matteo Fassan Andrea Ruzzenente 3,* Mafficini 1 Laura D. Wood 4 Vincenzo Corbo Davide Melisi 5 Giuseppe Malleo 6 Caterina Vicentini Giorgio Malpeli 1,3,6 Antonello Nicola Sperandio Paola Capelli 2 Anna Tomezzoli Calogero Iacono 3 Rita T. Lawlor 1,2 Claudio Bassi Ralph H. Hruban Alfredo Guglielmi Giampaolo Tortora Filippo de Braud 7 Aldo Scarpa ARC-Net Research Centre, University and Hospital Trust of Verona, Italy Department Pathology Diagnostics, Surgery, General...
To identify a clinical fistula risk score following distal pancreatectomy.Clinically relevant pancreatic (CR-POPF) pancreatectomy (DP) is dominant contributor to procedural morbidity, yet factors attributable CR-POPF and effective practices reduce its occurrence remain elusive.This multinational, retrospective study of 2026 DPs involved 52 surgeons at 10 institutions (2001-2016). CR-POPFs were defined by 2016 International Study Group criteria, models generated using stepwise logistic...
This multicenter study sought to prospectively evaluate a drain management protocol for pancreatoduodenectomy (PD).Recent evidence suggests value both selective placement and early removal PD. Both strategies have been associated with reduced rates of clinically relevant pancreatic fistula (CR-POPF)-the most common morbid complication after PD.The was applied 260 consecutive PDs performed at two institutions over 17 months. Risk ISGPF CR-POPF determined intraoperatively using the Fistula...
Objective: The REDISCOVER consensus conference aimed at developing and validate guidelines on the perioperative care of patients with borderline resectable (BR-) locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). Summary Background Data: Coupled improvements in chemotherapy radiation, contemporary approach to surgery supports resection BR-PDAC and, a lesser extent, LA-PDAC. Guidelines outlining selection for these are lacking. Methods: Scottish Intercollegiate Network (SIGN)...
Intratumour heterogeneity and phenotypic plasticity drive tumour progression therapy resistance1,2. Oncogene dosage variation contributes to cell-state transitions heterogeneity3, thereby providing a substrate for somatic evolution. Nonetheless, the genetic mechanisms underlying are still poorly understood. Here we show that extrachromosomal DNA (ecDNA) is major source of high-level focal amplification in key oncogenes contributor MYC pancreatic ductal adenocarcinoma (PDAC). We demonstrate...
To evaluate surgical performance in pancreatoduodenectomy using clinically relevant postoperative pancreatic fistula (CR-POPF) occurrence as a quality indicator.Accurate assessment of surgeon and institutional requires (1) standardized definitions for the outcome interest (2) comprehensive risk-adjustment process to control differences patient risk.This multinational, retrospective study 4301 pancreatoduodenectomies involved 55 surgeons at 15 institutions. Risk CR-POPF was assessed...
Objective: The aim of this study was to identify the optimal fistula mitigation strategy following pancreaticoduodenectomy. Background: utility technical strategies prevent clinically relevant postoperative pancreatic (CR-POPF) pancreatoduodenectomy (PD) may vary by circumstances anastomosis. Fistula Risk Score (FRS) identifies a distinct high-risk cohort (FRS 7 10) that demonstrates substantially worse clinical outcomes. value various in these particular high-stakes cases has not been...
Mixed adenoneuroendocrine carcinomas (MANECs) of the gastrointestinal tract are rare neoplasms characterized by coexisting exocrine and neuroendocrine neoplastic components. MANECs' histogenetic classification molecular characterization remain unclear, significantly affecting identification innovative therapeutic options for these tumors.The components 6 MANECs were microdissected subjected to simultaneous mutation assessment in selected regions 54 cancer-associated genes using Ion Torrent...
The aim of the study is to characterize postoperative acute pancreatitis (POAP).A standardized definition POAP after pancreaticoduodenectomy (PD) has been recently proposed, but specific studies are lacking.The patients were extracted from prospective database Pancreas Institute Verona. was defined as an elevation serum pancreatic amylase levels above upper limit normal (52 U/L) on day (POD) 0 or 1. endpoints included defining incidence and predictors investigating association with fistula...
<h3>Importance</h3> Chemotherapy is the recommended induction strategy in borderline resectable and locally advanced pancreatic ductal adenocarcinoma. However, associated results on an intention-to-treat basis are poorly understood. <h3>Objective</h3> To investigate pragmatically treatment compliance, conversion to surgery, survival outcomes of patients with adenocarcinoma undergoing primary chemotherapy. <h3>Design, Setting, Participants</h3> This prospective study took place a national...