A5043464919- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Hip and Femur Fractures
- Healthcare cost, quality, practices
- Gastric Cancer Management and Outcomes
- Pelvic and Acetabular Injuries
- Cancer Genomics and Diagnostics
- Pleural and Pulmonary Diseases
- Hernia repair and management
- Diversity and Career in Medicine
- Frailty in Older Adults
- Lymphoma Diagnosis and Treatment
National Institute for Health Research
2017-2024
University of Birmingham
2018-2024
University Hospital of Zurich
2019-2023
Erasmus MC Transplant Institute
2023
Erasmus MC Cancer Institute
2023
Erasmus University Rotterdam
2013-2023
Queen Elizabeth Hospital Birmingham
2017-2021
Queen Elizabeth University Hospital
2017-2019
Erasmus MC
2012-2019
University Hospitals Birmingham NHS Foundation Trust
2018-2019
Objective: To use the concept of benchmarking to establish robust and standardized outcome references after pancreatico-duodenectomy (PD). Background: Best achievable results PD are unknown. Consequently, comparisons among different cohorts, centers or with novel surgical techniques remain speculative. Methods: This multicenter study analyzes consecutive patients (2012–2015) undergoing in 23 international expert pancreas surgery. Outcomes without significant comorbidities major vascular...
<h3>Objective</h3> The value of surveillance for patients with Barrett9s oesophagus (BO) is under discussion given the overall low incidence neoplastic progression and lack discriminative tests risk stratification. Histological diagnosis low-grade dysplasia (LGD) only accepted predictor to date, but has a predictive value. aim this study was therefore evaluate p53 immunohistochemistry predicting in BO. <h3>Design</h3> We conducted case–control within prospective cohort 720 Patients who...
Advanced donor age has been identified as a risk factor when combined with warm ischemia time (WIT), eg, in donation after circulatory death (DCD). In several countries, DCD livers older than 60 years are not considered suitable due to concerns related poor graft function and development of ischemic cholangiopathy. this study, we evaluate outcomes liver transplantation using grafts from donors years. We analyzed (n = 315), comparing > 93) ≤ 222) our center between 2005 2015. End points...
To test the total burden of complications in early postoperative period after liver transplantation (LT) between donation circulatory death (DCD) and brain (DBD) grafts with novel Comprehensive Complication Index (CCI).LT is complex surgery increasing use high-risk pressuring current outcomes. DCD particular are associated ischemic-type biliary lesions (ITBL) subsequent impaired graft survival rates.Retrospective single-center study all LT since start program (2001-2015). CCI (at hospital...
Objective: The aim of this study was to investigate tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC), with and without hypothermic oxygenated perfusion (HOPE) before transplantation. Patients Methods: We analyzed all recipients HCC, transplanted between January 2012 September 2019 donation circulatory death (DCD) livers previous end-ischemic HOPE-treatment (n = 70, Center A). Tumor parameters key confounders were compared consecutive during the same observation...
In the United Kingdom, up to 20% of liver graft offers are not used for transplantation, and reasons refusal multifactorial consistent among transplant units.Liver grafts previously declined by other centers in Kingdom but transplanted our unit Birmingham between 2011 2015 were analyzed. According indicated reason previous declines, categorized into 3 groups: "quality," "logistics," "other reasons." Results compared with a matched, low-risk cohort livers primarily accepted at center.During...
Abstract The aim of this study was to investigate the impact hypoxia and hypotension during agonal phase donor warm ischemia time (DWIT) on hepatic ischemia/reperfusion injury (IRI) complications in donation after circulatory death (DCD) liver transplantation. A retrospective single‐center 93 DCD transplants (Maastricht type III) performed. DWIT divided into 2 periods: (from withdrawal treatment [WoT] until arrest) asystolic (circulatory arrest cold perfusion). drop <80% peripheral...
Acute kidney injury (AKI) is a common complication after liver transplantation and more frequently observed when high-risk grafts, such as donation circulatory death (DCD) grafts are used. Our aim was to investigate the impact of ischemia periods on development AKI in DCD transplantation.We performed 2-center retrospective study with 368 graft-recipients. Donor warm time (DWIT) divided into agonal phase (withdrawal life support-cardiac arrest) asystolic (cardiac arrest-start cold perfusion)....
The use of extended criteria donor (ECD) grafts has been associated with acute kidney injury (AKI) after liver transplantation. However, the relation between graft quality and development chronic disease (CKD) remains unknown. Therefore, aim this study was to analyze impact ECD for CKD All patients (2007-2015) transplanted end-stage at our center were assessed. Longterm function divided into 4 groups: no (estimated glomerular filtration rate [eGFR], ≥60 mL/minute/1.73 m2 ), mild (eGFR, 30-59...
To investigate the value of α-methylacyl-CoA racemase (AMACR) immunohistochemistry for predicting neoplastic progression in Barrett's oesophagus (BO).We conducted a case-control study within prospective cohort 720 BO patients. Patients who developed high-grade dysplasia or oesophageal adenocarcinoma were classified as cases, and patients without controls. AMACR expression was determined by 12 127 biopsies from 635 patients, scored independently two expert pathologists. Relative risks...
Parameters of retrieval surgery are meticulously documented in the United Kingdom, where up to 40% livers donation after circulatory death (DCD) donations. This retrospective analysis focuses on outcomes transplantation DCD livers, retrieved by different UK centers between 2011 and 2016. Donor recipient risk factors donor technique were assessed. A total 236 from 9 with a median score 5 (low risk) 7 points (high compared. The majority used University Wisconsin solution for aortic flush...