A5101747116- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Liver physiology and pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical site infection prevention
- Neuroendocrine Tumor Research Advances
- Dental materials and restorations
- Dental Erosion and Treatment
- Health and Medical Research Impacts
- Metabolism and Genetic Disorders
- Colorectal Cancer Treatments and Studies
- Innovations in Medical Education
- Colorectal Cancer Surgical Treatments
- Pelvic and Acetabular Injuries
- Pancreatic function and diabetes
- Dental Implant Techniques and Outcomes
- Hernia repair and management
Queen Elizabeth Hospital Birmingham
2010-2024
Queen Elizabeth Hospital
2013-2024
University of North Carolina at Chapel Hill
2024
University Hospitals Birmingham NHS Foundation Trust
2015-2024
University of Birmingham
2010-2023
Klinikum Saarbrücken
2023
Erasmus MC
2023
NIHR Surgical Reconstruction and Microbiology Research Centre
2022-2023
Allegheny Health Network
2023
Memorial Sloan Kettering Cancer Center
2023
<b>Objective</b> To determine the clinical effectiveness of wound edge protection devices in reducing surgical site infection after abdominal surgery. <b>Design</b> Multicentre observer blinded randomised controlled trial. <b>Participants</b> Patients undergoing laparotomy at 21 UK hospitals. <b>Interventions</b> Standard care or use a device during <b>Main outcome measures</b> Surgical within 30 days surgery, assessed by clinicians seven and patient’s self report for intervening period....
Successful and consistent isolation of primary human hepatocytes remains a challenge for both cell-based therapeutics/transplantation laboratory research. Several centres around the world have extensive experience in from non-diseased livers obtained donor liver surplus to surgical requirement or at hepatic resection tumours. These are an important but limited source cells therapy The capacity isolate diseased tissue removed transplantation would substantially increase availability However...
Human bone marrow mesenchymal stem cells (hMSCs) have shown benefit in clinical trials of patients with liver disease. Efficient delivery to target organs is critical improving their effectiveness. This requires an understanding the mechanisms governing cellular engraftment into liver. Binding hMSCs normal/injured tissue, purified extracellular matrices, and human hepatic sinusoidal endothelial (HSECs) were quantified static flow conditions. To define underpinning hMSC interactions,...
In the United Kingdom, up to 20% of liver graft offers are not used for transplantation, and reasons refusal multifactorial consistent among transplant units.Liver grafts previously declined by other centers in Kingdom but transplanted our unit Birmingham between 2011 2015 were analyzed. According indicated reason previous declines, categorized into 3 groups: "quality," "logistics," "other reasons." Results compared with a matched, low-risk cohort livers primarily accepted at center.During...
Ensuring that doctors in training acquire sufficient knowledge, experience and understanding of medical research is a universal longstanding issue which has been brought into sharper focus by the growth evidence based medicine. All healthcare systems preparing for practice have to balance acquisition specific clinical attitudes, knowledge skills with wider need ensure are equipped remain professionally competent as science advances. Most professional bodies acknowledge this requires trainee...
Retransplantation candidates are disadvantaged owing to lack of good-quality liver grafts. Strategies that can facilitate transplantation suboptimal grafts into retransplant require investigation. The aim was determine whether late retransplantation be performed safely with grafts, following normothermic machine perfusion.A prospectively enrolled group patients who required received a graft preserved via perfusion. This compared both historical and contemporaneous cohorts patient by cold...
Abstract Background Surgeon burnout has implications for patient safety and workforce sustainability. The aim of this study was to establish the prevalence among surgeons in UK during COVID‐19 pandemic. Methods This cross‐sectional online survey set National Health Service involved 601 across all specialities grades. Participants completed Maslach Burnout Inventory a bespoke questionnaire. Outcome measures included emotional exhaustion, depersonalisation low personal accomplishment, as...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis. Accurate preoperative assessment using computed tomography (CT) to determine resectability crucial in ensuring patients are offered the most appropriate therapeutic strategy. Despite use of classification guidelines, any interobserver variability between reviewing surgeons and radiologists may confound decisions influencing patient treatment pathways.
Mortality after severe complications hepatectomy (failure to rescue) is strongly linked center volume. The aim of this study was evaluate the risk factors for failure rescue in a high-volume center.
Although laparoscopic hepatectomy (LH) is associated with improved short-term outcomes compared to open (OH), it unknown whether frail patients also benefit from LH. The aim of this study was evaluate the impact frailty on post-operative after LH and OH.Consecutive who underwent OH between January 2011 December 2018 were identified a prospective database. Frailty assessed using modified Index (mFI), scoring mFI ≥ 1 deemed be frail.Of 1826 patients, 34.7% (N = 634) 18.6% 340) elderly (≥ 75...
Background Wound-edge protection devices (WEPDs) have been used in surgery for more than 40 years to reduce surgical site infection (SSI). No economic evaluation of WEPDs against any comparator has ever conducted. The aim the paper was assess whether are cost-effective reducing SSI compared standard care alone United Kingdom. Methods and Findings An conducted alongside ROSSINI trial. study perspective that UK National Health Service time horizon 30 days post-operatively. 21 hospitals. 760...