A5041418452- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Clinical Nutrition and Gastroenterology
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Renal Transplantation Outcomes and Treatments
- Congenital Anomalies and Fetal Surgery
- Liver Diseases and Immunity
- Childhood Cancer Survivors' Quality of Life
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Pregnancy and Medication Impact
- Adolescent and Pediatric Healthcare
- Gallbladder and Bile Duct Disorders
- Heavy Metal Exposure and Toxicity
- Porphyrin Metabolism and Disorders
- Drug Transport and Resistance Mechanisms
- Infant Nutrition and Health
- Neonatal Health and Biochemistry
- Hepatitis C virus research
- Child Nutrition and Feeding Issues
- Organ Donation and Transplantation
- Electrolyte and hormonal disorders
- Amino Acid Enzymes and Metabolism
Birmingham Women's Hospital
2018-2024
University of Birmingham
2023-2024
Indiana University – Purdue University Indianapolis
2024
University Hospitals Birmingham NHS Foundation Trust
2024
Birmingham Women’s and Children’s NHS Foundation Trust
2022-2023
Patient Advocate Foundation
2022
Birmingham Children's Hospital
2005-2021
Children's of Alabama
2012-2013
Pfizer (United Kingdom)
2009
Boston Children's Hospital
2002-2006
ABSTRACT Background Family screening is a main step for the diagnosis in Wilson disease. This study was undertaken to evaluate value of relative exchangeable copper family screening. Methods Data from were collected French National Center Reference Subjects who first‐ or second‐degree relatives index case underwent clinical examination and biological parameters. Results Of 127 subjects examined, abnormalities low ceruloplasminemia detected 21 subjects, corresponding 5 patients with disease,...
Congenital hepatic fibrosis (CHF) and Caroli syndrome are frequently associated with renal cystic diseases. They have a variable clinical course, the natural history is not well defined despite molecular advances. Our study describes manifestations long-term outcome in children this disorder.A retrospective case review of CHF at single centre diagnosed on basis features, radiological endoscopic evidence portal hypertension (PHT), compatible histopathological findings. Children were...
Long-term follow-up studies of paediatric onset autoimmune liver disease (AILD) are invaluable in helping better understand the clinical course disease. In day-to-day practice clinicians struggle with definitions whilst patients and parents lack clear prognostic information.
Little information is available on contemporary, prospectively collected data the long-term outcome of national cohorts children with biliary atresia.This study aimed to describe current a cohort atresia.All 93 cases atresia in United Kingdom and Ireland diagnosed between March 1993 February 1995 were followed up prospectively.A total 91 underwent Kasai portoenterostomy 15 individual centres. Only 2 centres treated more than 5 annually. Median age at last follow-up was 12 years (range...
Sheth J, Sharif K, Lloyd C, Gupte G, Kelly D, de Ville Goyet Millar AJ, Mirza DF, Chardot C. Staged abdominal closure after small bowel or multivisceral transplantation. Pediatr Transplantation 2012: 16: 36–40. © 2011 John Wiley & Sons A/S. Abstract: Following paediatric SBMT, size discrepancy between the recipient’s abdomen and graft may lead to ACS, dysfunction, death. We report our experience with SAC in these patients. Between 04/1993 03/2009, 57 children underwent 62 SBMTs. When...
Primary hyperoxaluria-I (PH-I) is a serious metabolic disease resulting in end-stage renal disease. Pre-emptive liver transplantation (PLT) for PH-I an option children with early diagnosis. There still little information on its effect long-term function this situation.Long-term assessment of was conducted using Schwartz's formula (estimated glomerular filtration rate-eGFR) four (Group A) undergoing PLT between 2002 and 2008, comparison done eight gender- sex-matched controls B) having other...
The histological prevalence of allograft fibrosis in asymptomatic children after liver transplantation (LT) is well documented. However, long-term graft and patient survival remain unclear. This retrospective multicenter study aims to determine the analyze outcome for patients transplanted childhood.We reviewed clinical data who had undergone 10-y protocol biopsies. We excluded with autoimmune hepatitis, primary sclerosing cholangitis, hepatitis B or C, retransplantation. In total, 494...
Neurologic problems postpediatric liver transplant have been reported in up to 46% of cases, and mortality is higher the pediatric age group compared with adults.An internal audit was performed all children undergoing solid organ Liver unit at Birmingham Children's Hospital identify neurologic complications.One hundred seventeen underwent 127 combined small bowel episodes over a 4-year period. were present after 31 (24.4%) involving 29 children. Seizures most common presentation (n=17;...
Selected infants with short bowel syndrome (SBS) and progressive intestinal failure associated liver disease (IFALD) may benefit from isolated transplantation (iLTx). The aim of the study is to identify risk factors for unfavourable outcome in iLTx.A retrospective review medical records 1998 2005 was undertaken. Risk were assessed by comparing long-term survivors those who died after iLTx.Fifteen iLTx performed 14 IFALD. All parenteral nutrition (PN) dependent, but had tolerated enterally...
Abstract Vitamin D deficiency and insufficiency are increasingly recognized in the general population, including healthy children. There is also an increasing emphasis on importance of vitamin status following pediatric liver transplantation specifically its relationship to metabolic bone disease growth retardation. has been associated with multiple immunological disorders adults. To our knowledge, this not systematically evaluated children undergoing date. Between October 2004 August 2008,...
Graft availability remains a problem in pediatric intestinal transplantation (IT), with most children waiting being less than 10 kg weight. In November 2004, wait-listed the United Kingdom were prioritized nationally to receive donor organs improve for IT. We aimed evaluate impact of this change on recipient population.Data regarding organ and allocation accessed from National Transplant database. Recipient demographics outcomes recorded Liver Unit Between 2001 2006, there 228 donors...
Background and Method. Combined liver kidney transplant (CLKT) is a recognized treatment option for end-stage renal disease due to primary hyperoxaluria (PH-I) cystic disorders, yet there only limited data on posttransplant function recovery. The objective of this study was assess postoperative children with PH-I (group A) undergoing CLKT compare cohort B) who received other indications. Results. Twenty-three patients underwent between 1994 2008 A: 9 patients; median age 8.6 [1.6–16.7]...
Abstract To compare the incidence of acute histologically proven rejection in children who have had a liver transplant for hepatoblastoma with control group transplanted biliary atresia ( EHBA ). A retrospective case notes based study was performed. Twenty patients were identified at single unit between 1991 and 2008. These matched as closely possible age, gender, year type immunosuppression used to (n = 60). There significant decrease rate assessed by activity index RAI ) (75% vs. 50%,...
Steroid-free immunosuppression protocols gained popularity in pediatric liver transplantation (pLT) after the introduction of IL-2–receptor blockade for induction therapy. We analyzed clinical and immunologic outcome data multicenter prospective observational ChilSFree study to compare impact steroid-free versus steroid-containing immunosuppressive therapy following pLT a real-life scenario. Two hundred forty-six children [55.3% male, age at median: 2.4 (range: 0.2–17.9) y] transplanted...