A5035448439- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Dialysis and Renal Disease Management
- Neurological Complications and Syndromes
- Full-Duplex Wireless Communications
- Hepatitis C virus research
- Parvovirus B19 Infection Studies
- Acute Kidney Injury Research
- Pharmacological Effects and Toxicity Studies
- Transplantation: Methods and Outcomes
- Metabolism and Genetic Disorders
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Organ Donation and Transplantation
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Renal Diseases and Glomerulopathies
- Clinical Nutrition and Gastroenterology
- Drug-Induced Hepatotoxicity and Protection
- Body Composition Measurement Techniques
- Aortic Disease and Treatment Approaches
University of Rome Tor Vergata
2021-2025
Policlinico Tor Vergata
2023-2024
Sapienza University of Rome
2012-2021
Queen Elizabeth Hospital Birmingham
2016
University Hospitals Birmingham NHS Foundation Trust
2016
NIHR Birmingham Liver Biomedical Research Unit
2016
National Institute for Health Research
2016
University of Birmingham
2016
Institute of Clinical Research
2016
Policlinico Umberto I
2010
Objective. The aim of our study was to evaluate the lymphocyte subpopulations and cytokines in peripheral blood patients with type-A Stanford acute aortic dissection (AAD group) determine whether inflammatory cells are present at site dissection.Methods. Thirty-five consecutive were evaluated for haemochrome (CD3+, CD4+, CD8+, CD19+, CD4+CD25+, CD16+CD56+, CD4+CD28−, CD8+CD28−) by flow cytometry. C-reactive protein (CRP), tumour necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-6, IL-8,...
Objectives. To determine whether tumour necrosis factor (TNF)-α blockers may reduce carotid intima-media thickness (cIMT) in patients with active rheumatoid arthritis (RA) steadily responsive to such therapy. Methods. From 287 consecutive RA attending our out-patient clinic and diagnosed on the basis of American College Rheumatology (ACR) criteria, 49 without traditional cardiovascular risk factors meeting requirements for TNF-α therapy were selected. Among them, 39 actually started...
The authors assessed the prevalence of neuropsychiatric manifestations occurring in patients with systemic lupus erythematosus (NPSLE), according to American College Rheumatology standardized definitions for NPSLE, and evaluated relationship between NPSLE antiphospholipid antibodies. Sixty-one consecutive SLE were studied. Neuropsychiatric consistent diagnosis occurred 44 (72%). Patients showed significantly higher levels anticardiolipin
Abstract Objective . To evaluate the efficacy of long‐term treatment with cyclosporin A (CSA) in systemic lupus erythematosus (SLE). Methods Thirty patients SLE whose condition was either poorly responsive or unresponsive to steroids and/or cytotoxic drugs were enrolled a prospective, nonrandomized study CSA. Patients hypertension hypercreatinemia excluded. Disease activity evaluated according measure. Assessments made prior entry and after 6, 12, 18, 24 months. Results Twenty‐seven...
<b><i>Objectives:</i></b> The aim of the study was to determine whether release by macrophages matrix metalloproteinase (MMP)-12 and vascular endothelial growth factor (VEGF) - leading inflammation, degradation neoangiogenesis represents an effective pathway that underlies aortic wall remodeling in Stanford type A acute dissection (AAD). <b><i>Methods:</i></b> Twenty-one consecutive patients with no genetic predisposition, AAD were selected. In...
Cognitive impairment and malnutrition are prevalent in patients on hemodialysis (HD), they negatively affect the outcomes of HD patients. Evidence suggests that cognitive may be associated, but clinical studies to assess this association lacking. The aim study was evaluate between evaluated by Montreal Assessment (MoCA) score nutritional status inflammation (MIS) We enrolled 84 (44 males 40 females; age: 75.8 years (63.5-82.7); vintage: 46.0 months (22.1-66.9)). MISs identified 34 (40%) as...
To investigate the thrombotic tendency in patients with systemic lupus erythematosus (SLE) by evaluating congenital or acquired abnormalities associated an increased risk of venous and/or arterial thrombosis.A total 57 SLE were included study. Twenty-one (37%) had a history thrombosis and 36 (63%) did not have such history. Sera from 50 healthy controls examined. Protein C, protein S, antithrombin, D-dimer, fibrinogen, homocysteine, anticardiolipin antibodies (aCL), anticoagulant (LAC),...
Acute kidney injury (AKI) is a common complication after liver transplantation and more frequently observed when high-risk grafts, such as donation circulatory death (DCD) grafts are used. Our aim was to investigate the impact of ischemia periods on development AKI in DCD transplantation.We performed 2-center retrospective study with 368 graft-recipients. Donor warm time (DWIT) divided into agonal phase (withdrawal life support-cardiac arrest) asystolic (cardiac arrest-start cold perfusion)....
Chronic kidney disease (CKD) is a highly prevalent condition in the world. Neurological, psychological, and cognitive disorders, related to CKD, could contribute morbidity, mortality, poor quality of life these patients. The aim this study was assess neurological, imbalance patients with CKD on conservative replacement therapy. Seventy-four clinically stable affected by therapy, therapy (hemodialysis (HD), peritoneal dialysis (PD)), or transplantation (KT) 25 healthy controls (HC), matched...
Abstract Background Cystic fibrosis (CF) is one of the most frequent genetic diseases and median survival these patients has improved in last few decades, therefore it becomes necessary to evaluate long-term complications as renal cardiovascular risk factors. Aim study To incidence, manifestations disease possible association with metabolic endothelial dysfunction markers CF population. Materials methods We performed a cross-sectional, observational on 226 patients. Clinical laboratory...
In chronic kidney disease (CKD) patients, several risk factors contribute to the development of endothelial dysfunction (ED), which can be described as an alteration in cell structure or function endothelium. Among well-known CKD-related capable altering production endothelium-derived relaxing factors, we include asymmetric dimethylarginine increase, reduced dimethylamine hydrolase enzyme activity, low-grade systemic inflammation, hyperhomocysteinemia, oxidative stress, insulin resistance,...
Background: Chronic kidney disease (CKD) will become the fifth leading cause of death in world by 2040. It is fundamental to prevent and treat this pathology reduce its impact on national health costs. This trial’s aim evaluate effects induced a combination consumed functional foods (FFs) with adapted physical activity (APA) progression CKD-related comorbidities. Methods: The study lasted 12 weeks. We divided 40 CKD patients into four groups: mixed (FF + APA), APA, FF control group (usual...
Nowadays, better immunosuppressors have decreased the rates of acute rejection in kidney transplantation, but also led to emergence BKV-associated nephropathy (BKVAN). Therefore, we prospectively investigated BKV load plasma and urine samples a cohort transplants, receiving basiliximab combined with mycophenolate mofetil-based triple immunotherapy, evaluate difference between replication during first 3 months post-transplantation, characterized by non-depleting action basiliximab, versus...
Abstract Toll‐like receptor 9 (TLR‐9) and TLR‐7 may have a role in the production of anti‐DNA anti‐RNA autoantibodies, respectively, but murine models do not clearly demonstrate their contribution to development systemic lupus erythematosus (SLE). Herein we describe patient with SLE who had long‐lasting remission her autoimmune disease after an antibody deficiency resembling common variable immunodeficiency (CVID). After CVID developed, anti–double‐stranded DNA antibodies disappeared,...