A5003629514- Bone health and treatments
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Pharmaceutical studies and practices
- Cancer Treatment and Pharmacology
- Medical Imaging and Pathology Studies
- Colorectal Cancer Treatments and Studies
- Magnesium in Health and Disease
- Cancer, Lipids, and Metabolism
- Biosimilars and Bioanalytical Methods
- Boron Compounds in Chemistry
- Cancer Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Prostate Cancer Treatment and Research
- Pharmaceutical Economics and Policy
- Atherosclerosis and Cardiovascular Diseases
- Childhood Cancer Survivors' Quality of Life
- Protein Tyrosine Phosphatases
- HER2/EGFR in Cancer Research
- Bone health and osteoporosis research
Italian Medicines Agency
2015-2024
European Medicines Agency
2020-2024
Sapienza University of Rome
2002-2014
Università Campus Bio-Medico
2006-2011
Medica (Italy)
2008-2010
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2008
Campus Bio Medico University Hospital
2005-2007
Columbia University
2004-2005
University of Bari Aldo Moro
2003
Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation activity. stimulates migration RANK-expressing tumor cells vitro, conversely inhibited OPG.We examined mRNA expression levels RANKL/RANK/OPG publicly available microarray dataset 295 primary breast cancer patients. We next analyzed RANK immunohistochemistry an independent series 93 specimens investigated possible...
Abstract Purpose: On the basis of stimulating data on animals reporting that weekly regimens zoledronic acid (ZA) were effective in reducing skeletal tumor burden, we designed a study humans to investigate potential antiangiogenic role low-dose therapy with ZA patients malignancies. Experimental Design: Twenty-six consecutive advanced solid cancer and bone metastases received 1 mg every week for four times (days 1, 7, 14, 21) followed by 4 standard 28-day schedule repeated thrice 28, 56,...
The authors assessed the prevalence of neuropsychiatric manifestations occurring in patients with systemic lupus erythematosus (NPSLE), according to American College Rheumatology standardized definitions for NPSLE, and evaluated relationship between NPSLE antiphospholipid antibodies. Sixty-one consecutive SLE were studied. Neuropsychiatric consistent diagnosis occurred 44 (72%). Patients showed significantly higher levels anticardiolipin
Summary In the present study we investigated potential role of Toll-like receptor 4 (TLR-4) Asp299Gly and Thr399Ile polymorphisms as risk factors in development gastric cancer. TLR-4 were 171 Italian patients with sporadic cancer 151 controls. Unconditional regression (odds ratio 95% confidence intervals) used to investigate association studied polymorphism is linked an increased susceptibility (P = 0·023 hazard 3·62). No significant for was found. subgroup intestinal-type cancer, a...
The third multistakeholder Paediatric Strategy Forum organised by ACCELERATE and the European Medicines Agency focused on immune checkpoint inhibitors for use in combination therapy children adolescents. As inhibitors, both as monotherapy combinations have shown impressive success some adult malignancies early phase trials of single agent now been completed, it seemed an appropriate time to consider opportunities paediatric studies used combination. Among patients, clinical demonstrated a...
Abstract Attempts to enhance patients’ immune responses malignancies have been largely unsuccessful. We now describe an immune-escape mechanism mediated by the inhibitory receptor Ig-like transcript 3 (ILT3) that may be responsible for such failures. Using a humanized SCID mouse model, we demonstrate soluble and membrane ILT3 induce CD8+ T suppressor cells prevent rejection of allogeneic tumor transplants. Furthermore, found patients with melanoma, carcinomas colon, rectum, pancreas produce...
To investigate the thrombotic tendency in patients with systemic lupus erythematosus (SLE) by evaluating congenital or acquired abnormalities associated an increased risk of venous and/or arterial thrombosis.A total 57 SLE were included study. Twenty-one (37%) had a history thrombosis and 36 (63%) did not have such history. Sera from 50 healthy controls examined. Protein C, protein S, antithrombin, D-dimer, fibrinogen, homocysteine, anticardiolipin antibodies (aCL), anticoagulant (LAC),...
Magnesium plays a role in large number of cellular metabolic reactions. Cetuximab is able to induce hypomagnesemia by interfering with magnesium (Mg(2+)) transport the kidney. We designed this trial investigate if Mg(2+) serum level modifications may be related clinical response and outcome advanced colorectal cancer patients during treatment cetuximab plus irinotecan.Sixty-eight heavily pretreated metastatic were evaluated for levels at following time points: before; 6 hours; 1, 7, 14, 21,...
Alexithymia is conceptualized as a disorder of emotion regulation mechanisms, which involves dissociation emotional and physical responses to life events bodily sensations. Our results might suggest possible relationship between the alexithymic construct TNF levels in RA patients. These preliminary findings corroborate integrated bidirectional interactions neuropsychological mechanisms neuroendocrine-immune system patients affected by autoimmune diseases contribute finding common biological...