A5001563233- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound and Hyperthermia Applications
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Advanced MRI Techniques and Applications
- Genetic factors in colorectal cancer
- MRI in cancer diagnosis
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Pancreatic function and diabetes
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
Columbia University Irving Medical Center
2016-2025
Columbia University
2014-2025
Morgan Stanley Children's Hospital
2006-2025
Center for Digestive and Liver Diseases
2025
LMU Klinikum
2025
Ludwig-Maximilians-Universität München
2025
NewYork–Presbyterian Hospital
2002-2024
Texas Health Dallas
2020
New York Hospital Queens
2000-2019
Presbyterian Hospital
2000-2019
Helene Zinszner, Masahiko Kuroda, XiaoZhong Wang, Nikoleta Batchvarova, Richard T. Lightfoot, Helen Remotti, James L. Stevens, and David Ron Skirball Institute of Biomolecular Medicine, the Departments Cell Biology, Kaplan Cancer Center, New York University (NYU) Medical York, 10016 USA; Adirondack Biomedical Research Facility, Lake Placid, 12946 Department Pathology, Cornell 10021 USA
Doublecortin-like kinase 1 protein (DCLK1) is a gastrointestinal tuft cell marker that has been proposed to identify quiescent and tumor growth-sustaining stem cells. DCLK1⁺ cells are increased in inflammation-induced carcinogenesis; however, the role of these within epithelium their potential as cancer-initiating poorly understood. Here, using BAC-CreERT-dependent genetic lineage-tracing strategy, we determined subpopulation extremely long lived possesses rare abilities. Moreover, ablation...
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) not defined. Here, we found that subdiaphragmatic vagotomy in LSL-Kras +/G12D;Pdx1-Cre (KC) mice accelerated PDAC development, whereas treatment with systemic muscarinic agonist bethanechol restored normal KC phenotype, thereby suppressing tumorigenesis caused...
Molecular characterization has the potential to advance management of pediatric cancer and high-risk hematologic disease. The clinical integration genome sequencing into standard practice been limited utility identify clinically impactful information beyond targetable alterations underestimated. Precision in Pediatric Sequencing (PIPseq) Program at Columbia University Medical Center instituted prospective next generation (NGS) for disorders risk treatment failure. We performed whole exome...
Abstract Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood 1–5 . Here we demonstrate that genetic depletion HSCs changes WNT activity zonation hepatocytes, leading to marked alterations regeneration, cytochrome P450 metabolism injury. We identify R-spondin 3 (RSPO3), an HSC-enriched modulator signalling, as responsible for these hepatocyte-regulatory...
Abstract Purpose: Recent studies have reported high frequencies of somatic mutations in the phosphoinositide-3-kinase catalytic-α (PIK3CA) gene various human solid tumors. More than 75% those are clustered helical (exon 9) and kinase domains 20). The three hot-spot mutations, E542K, E545K, H1047R, been proven to elevate lipid activity PIK3CA activate Akt signaling pathway. mutational status intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) has not evaluated previously....
Hepatocellular carcinoma (HCC) incidence has increased in the US and also one of fastest growing death rates any cancer. The purpose current study was to discover novel genome-wide aberrant DNA methylation patterns HCC tumors that are predominantly HCV-related. Infinium HumanMethylation 450K BeadChip arrays were used examine profiles 66 pairs tumor adjacent non-tumor tissues. After Bonferroni adjustment, a total 130,512 CpG sites significantly differed level compared with tissues, 28,017...
MicroRNAs (miRNA) are abundant in the circulation and play a central role diverse biologic processes; they may be useful for early diagnosis of hepatocellular carcinoma.We conducted two-phase, case-control study (20 pairs discovery set 49 validation set) to test hypothesis that genome-wide dysregulation circulating miRNAs differentiates carcinoma cases from controls. Taqman low-density arrays were used examine miRNA expression set, quantitative real-time PCR was validate candidate both...
Wanglong Qiu 1 , Fikret Sahin 3,4 Christine A. Iacobuzio-Donahue 3 Dario Garcia-Carracedo Wendy M. Wang Chia-Yu Kuo Doris Chen Dan E. Arking 5 Andrew Lowy 6 Ralph H. Hruban Helen Remotti 2 and Gloria Su 1,2* The Departments of Otolaryngology Head Neck Surgery, Columbia University College Physicians Surgeons, New York, NY 10032 Department Pathology, Sol Goldman Pancreatic Cancer research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21205 4 Microbiology Department, School...