A5062377553- RNA modifications and cancer
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Biomedical Text Mining and Ontologies
- Bioinformatics and Genomic Networks
- Pulmonary Hypertension Research and Treatments
- Cancer-related gene regulation
- Gene expression and cancer classification
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Protist diversity and phylogeny
- Semantic Web and Ontologies
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Sirtuins and Resveratrol in Medicine
- Cell Adhesion Molecules Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Endoplasmic Reticulum Stress and Disease
- Intracranial Aneurysms: Treatment and Complications
University of California, San Francisco
1997-2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Zhongshan Hospital
2023-2025
Fudan University
2023-2025
Sun Yat-sen University
2023-2025
South China Normal University
2022-2025
Huadong Hospital
2025
Sir Run Run Shaw Hospital
2015-2024
Zhejiang University
2015-2024
Zhejiang Cancer Hospital
2021-2024
Abstract Background N6-methyladenosine (m 6 A) has emerged as a significant regulator of the progress various cancers. However, its role in lung adenocarcinoma (LUAD) remains unclear. Here, we explored biological function and underlying mechanism methyltransferase-like 3 (METTL3), main catalyst m A, LUAD progression. Methods The expression METTL3, YTHDF1 SLC7A11 were detected by immunochemistry or/and online datasets patients. effects METTL3 on cell proliferation, apoptosis ferroptosis...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic, aggressive cancer that frequently progresses and spreads by metastasis to the liver 1 . Cancer-associated fibroblasts, extracellular matrix type I collagen (Col I) support 2,3 or restrain progression of PDAC may impede blood supply nutrient availability 4 The dichotomous role stroma in PDAC, mechanisms through which it influences patient survival enables desmoplastic cancers escape limitation, remain poorly...
The global challenge posed by cancer, marked rising incidence and mortality rates, underscores the urgency for innovative therapeutic approaches. PI3K/Akt signaling pathway, frequently amplified in various cancers, is central regulating essential cellular processes. Its dysregulation, often stemming from genetic mutations, significantly contributes to cancer initiation, progression, resistance therapy. Concurrently, ferroptosis, a recently discovered form of regulated cell death...
SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as potential therapeutic target in variety of neurodegenerative diseases, including Parkinson’s disease (PD). Our previous study demonstrates had neuroprotective effect on rotenone-induced PD cell model, however, the exact mechanism unknown. In this study, we investigated underlying mechanism. We established stable overexpression line using lentivirus...
Pulmonary arterial hypertension (PAH) is related to inflammation, and the lncRNA H19 associated with inflammation. However, whether PDGF-BB-H19-let-7b-AT1R axis contributes pathogenesis of PAH has not been thoroughly elucidated date. This study investigated role in its mechanism. In present study, SD rats, C57/BL6 mice H19−/− were injected monocrotaline (MCT) establish a model. was detected cytokine-stimulated pulmonary smooth muscle cells (PASMCs), serum lungs rats/mice. overexpression...
The fusion of autophagosomes and endosomes/lysosomes, also called autophagosome maturation, ensures the degradation autophagic cargoes. It is an important regulatory step macroautophagy/autophagy process. STX17 key autophagosomal SNARE protein that mediates maturation. Here, we report acetylation regulates its activity degradation. histone acetyltransferase CREBBP/CBP deacetylase HDAC2 specifically regulate STX17. In response to cell starvation MTORC1 inhibition, inactivation CREBBP leads...
Significance T cells recognize their targets via T-cell receptors (TCRs), which in the case of CD8 + bind to MHC-I:antigen complexes on surface target cells. Many cancer evade immune recognition and killing by down-regulating MHC-I AgPPM. Here, we show how histone acetyl transferases p300/CBP together with NF-κB epigenetically regulate expression molecules, immunoproteasome subunits, peptide transporter enable proper antigen presentation. Notably, this pathway is frequently disrupted human...
Continuous turnover of intracellular components by autophagy is necessary to preserve cellular homeostasis in all tissues. Despite recent advances identifying autophagy-related genes and understanding the functions developmental pathological conditions, so far, role platelet, a specific anucleate cell type, poorly understood. In this study, we showed that human platelets express proteins ATG5, ATG7, LC3. The same as nucleated mammalian cells, was stimulated starvation or MTOR inhibitor...
Abstract Background Hypoxia mediated pulmonary hypertension (HPH) is a lethal disease and lacks effective therapy. CircRNAs play significant roles in physiological process. Recently, circRNAs are found to be m 6 A-modified. The abundance of was influenced by A. Furthermore, the significance A has not been elucidated HPH yet. Here we aim investigate transcriptome-wide map HPH. Results Differentially expressed detected lungs rats. M significantly reduced hypoxia vitro. were mainly from...
Angiotensin-converting enzyme 2 (ACE2) protects against hypoxic pulmonary hypertension (HPH) by inhibiting the proliferation and migration of artery smooth muscle cells (PASMCs). Under hypoxia, hypoxia-inducible factor 1α (HIF-1α) inhibits ACE2 indirectly; however, underlying mechanism is unclear. In present study, we found that exposure to chronic hypoxia stimulated microRNA (miRNA) let-7b expression in rat lung via a HIF-1α-dependent pathway. Let-7b downregulated directly targeting coding...
Complement receptor of immunoglobulin superfamily (CRIg) is expressed on liver macrophages and directly binds complement component C3b or Gram-positive bacteria to mediate phagocytosis. CRIg plays important roles in several immune-mediated diseases, but it not clear how its pathogen recognition phagocytic functions maintain homeostasis prevent disease. We previously associated cytolysin-positive Enterococcus faecalis with severity alcohol-related Here, we demonstrate that reduced tissues...
Abstract Recent studies have demonstrated that one‐carbon metabolism plays a significant role in cancer development. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), mitochondrial enzyme of metabolism, has been reported to be dysregulated many cancers. However, the specific and mechanism MTHFD2 lung adenocarcinoma (LUAD) still remains unclear. In this study, we evaluated clinicopathological prognostic values LUAD patients. We conducted series functional experiments vivo vitro explore...