A5013782469- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunotherapy and Immune Responses
- Palliative Care and End-of-Life Issues
- Cancer Immunotherapy and Biomarkers
- Histone Deacetylase Inhibitors Research
- Dysphagia Assessment and Management
University of California, San Diego
2021
University of California, San Francisco
2021
Significance T cells recognize their targets via T-cell receptors (TCRs), which in the case of CD8 + bind to MHC-I:antigen complexes on surface target cells. Many cancer evade immune recognition and killing by down-regulating MHC-I AgPPM. Here, we show how histone acetyl transferases p300/CBP together with NF-κB epigenetically regulate expression molecules, immunoproteasome subunits, peptide transporter enable proper antigen presentation. Notably, this pathway is frequently disrupted human...
Background: The morbidity and mortality of interstitial lung disease (ILD) is high, despite novel therapeutics. Recognizing unmet needs for symptom management, advance care planning (ACP), support people with ILD their families, we developed a palliative care-ILD collaborative pilot program to improve access care. Methods: In the quantitative arm this mixed-methods study, evaluated which patients were cared through co-management impact on rates ACP opioid prescribing. qualitative arm,...