A5062204227- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Diabetes and associated disorders
- Alcohol Consumption and Health Effects
- Drug Transport and Resistance Mechanisms
- Immune cells in cancer
- Liver physiology and pathology
- Plant Molecular Biology Research
- Phagocytosis and Immune Regulation
- Chromosomal and Genetic Variations
- Pancreatic function and diabetes
- Genomics and Chromatin Dynamics
- Pancreatic and Hepatic Oncology Research
University of Edinburgh
2021-2024
MRC Centre for Regenerative Medicine
2024
Centre for Inflammation Research
2021-2024
The Queen's Medical Research Institute
2021-2022
Complement receptor of immunoglobulin superfamily (CRIg) is expressed on liver macrophages and directly binds complement component C3b or Gram-positive bacteria to mediate phagocytosis. CRIg plays important roles in several immune-mediated diseases, but it not clear how its pathogen recognition phagocytic functions maintain homeostasis prevent disease. We previously associated cytolysin-positive Enterococcus faecalis with severity alcohol-related Here, we demonstrate that reduced tissues...
Abstract Cellular identity requires the concerted action of multiple transcription factors (TFs) bound together to enhancers cell-type-specific genes. Despite TFs recognizing specific DNA motifs within accessible chromatin, this information is insufficient explain how select 1 . Here we compared four different TF combinations that induce cell states, analysing genome occupancy, chromatin accessibility, nucleosome positioning and 3D organization at resolution. We show motif recognition on...
Background: The farnesoid X receptor (FXR) is a leading therapeutic target for metabolic dysfunction–associated steatohepatitis (MASH)-related fibrosis. INT-767, potent FXR agonist, has shown promise in preclinical models. We aimed to define the mechanisms of INT-767 activity experimental MASH and dissect cellular molecular targets agonism human disease. Methods: Leptin-deficient ob / mice were fed MASH-inducing diet 15 weeks before study started. After baseline liver biopsy stratification,...