A5048082989- Neurobiology and Insect Physiology Research
- Thyroid Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Insect Utilization and Effects
- Bone fractures and treatments
- Circadian rhythm and melatonin
- Orthopedic Surgery and Rehabilitation
- Radiopharmaceutical Chemistry and Applications
- Animal Behavior and Reproduction
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Biochemical Analysis and Sensing Techniques
- Elbow and Forearm Trauma Treatment
- PARP inhibition in cancer therapy
- Lipid metabolism and biosynthesis
- Birth, Development, and Health
- CRISPR and Genetic Engineering
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Spine and Intervertebral Disc Pathology
Shenzhen Bay Laboratory
2020-2025
Chongqing University
2018-2024
Soochow University
2021-2024
University of Electronic Science and Technology of China
2024
Xiamen University
2021-2024
University of Chinese Academy of Sciences
2014-2023
Nanjing Institute of Geology and Paleontology
2023
Chinese Academy of Sciences
2023
Hangzhou Normal University
2023
Cornell University
2022
The purpose of this study is to develop and validate a nomogram model combing radiomics features clinical characteristics preoperatively differentiate grade 1 2/3 tumors in patients with pancreatic neuroendocrine (pNET).Experimental Design: A total 137 who underwent contrast-enhanced CT from two hospitals were included study. the second hospital (n = 51) selected as an independent validation set. arterial phase was for feature extraction. Mann-Whitney U test least absolute shrinkage...
Deficiency in autophagy, a lysosome-dependent cell degradation pathway, has been associated with variety of diseases especially cancer. Recently, the activation autophagy by hepatitis B virus X (HBx) protein, which is implicated (HBV)-associated hepatocellular carcinoma (HCC), identified hepatic cells. However, underlying mechanism and relevance HBx-activated to carcinogenesis caused HBV remain elusive. Here, transfection genomic DNA HBx hepatoma cells, we showed that HBV- or HBx-induced...
Starvation induces sustained increase in locomotion, which facilitates food localization and acquisition hence composes an important aspect of food-seeking behavior. We investigated how nutritional states modulated starvation-induced hyperactivity adult Drosophila. The receptor the adipokinetic hormone (AKHR), insect analog glucagon, was required for hyperactivity. AKHR expressed a small group octopaminergic neurons brain. Silencing AKHR+ blocking octopamine signaling these eliminated...
The protein deacetylase, sirtuin 1 (SIRT1), involved in regulating hepatic insulin sensitivity, shows circadian oscillation and regulates the clock. Recent studies show that misalignment leads to resistance (IR); however, underlying mechanisms are largely unknown. Here, we CLOCK brain muscle ARNT-like (BMAL1), two core transcription factors, correlated with sensitivity. Knockdown of or BMAL1 induces IR, whereas their ectopic expression attenuates IR. Moreover, change sensitivity is impaired...
Despite recent advances in understanding the functions of autophagy developmental and pathological conditions, underlying mechanism where how autophagosomal structures acquire membrane remains enigmatic. Here, we provide evidence that post-Golgi traffic plays a critical role autophagosome formation. Increased secretion constitutive cargo from trans-Golgi network (TGN) to plasma induced formation microtubule-associated protein light chain 3 (LC3)-positive structures. At early phase autophagy,...
High-altitude cerebral edema (HACE) is the severe type of acute mountain sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but exact mechanisms underlying HACE are not fully understood. Human volunteers ascended to high altitude (3860 m, 2 days), rats were exposed hypoxia in a hypobaric chamber (5000 days). was evaluated by Lake Louise Score (LLS), plasma corticotrophin-releasing hormone (CRH) cytokines TNF-α, IL-1β, IL-6 measured humans. Subsequently,...
Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective sources ensure dietary amino acid plays a critical role in homeostasis. By using quantitative feeding assay, we show that three acids, L-glutamate (L-Glu), L-alanine (L-Ala) L-aspartate (L-Asp), but not their D-enantiomers or other 17 natural L-amino acids combined, rapidly promote food consumption fruit fly Drosophila melanogaster. This feeding-promoting effect independent mating...
Abstract Obesity imposes a global health threat and calls for safe effective therapeutic options. Here, we found that protein-rich diet significantly reduced body fat storage in fruit flies, which was largely attributed to dietary cysteine intake. Mechanistically, increased the production of neuropeptide FMRFamide (FMRFa). Enhanced FMRFa activity simultaneously promoted energy expenditure suppressed food intake through its cognate receptor (FMRFaR), both contributing loss effect. In body,...
SopF, a newly discovered effector secreted by Salmonella pathogenicity island-1 type III secretion system (T3SS1), was reported to target phosphoinositide on host cell membrane and aggravate systemic infection, while its functional relevance underlying mechanisms have yet be elucidated. PANoptosis (pyroptosis, apoptosis, necroptosis) of intestinal epithelial cells (IECs) has been characterized as pivotal defense limit the dissemination foodborne pathogens, whereas effect SopF IECs induced is...
Circadian misalignment induces insulin resistance in both human and animal models, skeletal muscle is the largest organ response to insulin. However, how circadian clock regulates sensitivity underlying molecular mechanisms are still largely unknown. Here we show locomotor output cycles kaput (CLOCK) brain aryl hydrocarbon receptor nuclear translocator-like protein (BMAL)-1, two core transcription factors, down-regulated insulin-resistant C2C12 myotubes mouse muscle. Furthermore, signaling...
Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and 2 diabetes, but any treatment toward development of DPN not yet available. Axon degeneration an early feature many neuropathies, including DPN. Delay axon has beneficial effects on various neurodegenerative diseases, its effect to be elucidated. Deficiency Sarm1 significantly attenuates several models, deficiency still unclear. In this study, we show that knockout mice exhibit normal glucose metabolism...
The function of the central nervous system to regulate food intake can be disrupted by sustained metabolic challenges such as high-fat diet (HFD), which may contribute various disorders. Previously, we showed that a group octopaminergic (OA) neurons mediated starvation-induced hyperactivity, an important aspect food-seeking behavior (Yu et al., 2016). Here find HFD specifically enhances this behavior. Mechanistically, increases excitability these OA hunger hormone named adipokinetic (AKH),...
Abstract Objectives Nedd4 (neural precursor cell expressed developmentally down‐regulated protein 4) is a member of the HECT E3 ubiquitin ligases, and elevated in prostate, bladder colorectal cancers, promotes colonic population expansion. Up to now, molecular mechanisms how functions, have not been well understood. Materials methods In this study, sh RNA was used reduce expression human prostate carcinoma line DU 145. To analyse effects on proliferation, MTT colony formation assays were...
LC 3 is a key autophagy‐related protein involved in both autophagosome formation and autophagy cargo recruitment. Despite these functions being exerted by deacetylated 3, this more abundantly distributed its acetylated form. Here, we reveal that the stability recognition ability of are highly dependent on acetylation. Through detecting diffusion rate soluble fluorescence recovery after photobleaching ( FRAP ), found nutrient‐state‐related acetylation inhibited complex formation. Acetylation...
Lenvatinib has shown efficacy in treating radioiodine-refractory differentiated thyroid cancer (RR-DTC) the multinational phase III SELECT study; however, it not been tested Chinese patients with RR-DTC.
Cells control their metabolism through modulating the anabolic and catabolic pathways. TP53INP2/DOR (tumor protein p53 inducible nuclear 2), participates in cell catabolism by serving as a promoter of autophagy. Here we uncover novel function TP53INP2 synthesis, major biosynthetic energy-consuming process. localizes to nucleolus its nucleolar localization signal (NoLS) located at C-terminal domain. Chromatin immunoprecipitation (ChIP) assays detected an association with ribosomal DNA (rDNA),...
Sweet taste perception, a critical aspect of the initiation feeding behavior, is primarily regulated by an animal’s internal metabolic state. However, non-metabolic factors, such as motivational and emotional states, can also influence peripheral sensory processing hence behavior. While mating experience known to induce changes, its broader impact on other innate behaviors remains largely uncharacterized. In this study, we demonstrated that failure male fruit flies suppressed sweet...
Sweet taste perception, a critical aspect of the initiation feeding behavior, is primarily regulated by an animal’s internal metabolic state. However, non-metabolic factors, such as motivational and emotional states, can also influence peripheral sensory processing hence behavior. While mating experience known to induce changes, its broader impact on other innate behaviors remains largely uncharacterized. In this study, we demonstrated that failure male fruit flies suppressed sweet...
In patients with subarachnoid hemorrhage (SAH), the damage of blood-brain barrier (BBB) can be life-threatening. Mesenchymal stem cells are widely used in clinical research due to their pleiotropic properties. This study is aimed at exploring effect BMSCs regulating astrocytes on BBB after SAH.The SAH model was established by perforating blood vessels. were transfected TSG-6 inhibitor plasmid and cocultured astrocytes. Intravenous transplantation utilized treat rats. We performed ELISA,...
Human health is facing a host of new threats linked to unbalanced diets, including high-sugar diet (HSD), which contributes the development both metabolic and behavioral disorders. Studies have shown that diet-induced dysfunctions can be transmitted multiple generations offspring exert long-lasting burden. Meanwhile, whether how abnormalities remains largely unclear. Here, we showed ancestral HSD exposure suppressed sweet sensitivity feeding behavior in Drosophila. These deficits were...