A5102773858- Protein Degradation and Inhibitors
- Advanced Breast Cancer Therapies
- Sarcoma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Fish Ecology and Management Studies
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Genomics and Chromatin Dynamics
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Aerogels and thermal insulation
- Bone Tumor Diagnosis and Treatments
- Immune cells in cancer
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Marine and fisheries research
- Vascular Tumors and Angiosarcomas
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
Sun Yat-sen University
2017-2025
Peking University
2021-2025
Peking University Third Hospital
2021-2025
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
First Automotive Works (China)
2017-2024
Taiyuan University of Technology
2023
Dana-Farber Cancer Institute
2022-2023
Affiliated Hospital of Shaanxi University of Chinese Medicine
2018-2023
Guangdong Food and Drug Vocational College
2014-2018
Zhejiang University
2018
The purpose of this study is to develop and validate a nomogram model combing radiomics features clinical characteristics preoperatively differentiate grade 1 2/3 tumors in patients with pancreatic neuroendocrine (pNET).Experimental Design: A total 137 who underwent contrast-enhanced CT from two hospitals were included study. the second hospital (n = 51) selected as an independent validation set. arterial phase was for feature extraction. Mann-Whitney U test least absolute shrinkage...
Background/Aims: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. However, molecular mechanisms regulating osteosarcoma tumorigenesis progression are still poorly understood. Circular RNAs (circRNAs) have been identified as microRNA sponges involved many important biological processes. This study aims to investigate global changes expression pattern of circRNAs provide a comprehensive understanding differentially expressed circRNAs. Methods:...
Abstract Previous researches have demonstrated the meaning of CTSB for progress several tumors, whereas few clues about its immunological characteristic in gliomas. Here we systematically explored biologic features and clinical significance 699 glioma cases TCGA 325 CGGA were respectively included as training validating cohorts. R software was used data analysis mapping. We found that remarkably highly-expressed HGG, IDH wild type, 1p19q non-codeletion MGMT promoter unmethylation type...
Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that biological activities are intimately related to metabolites. In current investigation, we aimed comparatively explore effects tetrahydrocurcumin (THC), octahydrocurcumin (OHC), CUR, elucidate underlying action mechanisms on experimental mice...
Abstract Osteosarcoma is the most common primary bone tumor in children and adolescents. Many patients with osteosarcoma always develop drug resistance to current chemotherapy regimens, which induces a poor prognosis. And cancer stem cells (CSCs) have been reported possess properties self-renew maintain phenotype of tumor, may lead clinical treatment failure. Thus, it an urgent task several potentially useful therapeutic agents, could target CSCs osteosarcoma. This study aims clarify vitro...
Malignancy of cancer cells depends on the active transcription tumor-associated genes. Recently, unique clusters transcriptional enhancers, termed super-enhancers, have been reported to drive expression genes that define cell identity. In this study, we characterized specific super-enhancer-associated osteosarcoma, and explored their potential therapeutic value.Super-enhancer regions were through chromatin immunoprecipitation sequencing (ChIP-seq). RT-qPCR was used detect mRNA level CDK7 in...
Abstract In tumor therapeutics, the transition from conventional cytotoxic drugs to targeted molecular therapies, such as those targeting receptor tyrosine kinases, has been pivotal. Despite this progress, clinical outcomes have remained modest, with glioblastoma patients' median survival stagnating at less than 15 months. This underscores urgent need for more specialized treatment strategies. Our review delves into progression toward immunomodulation in glioma treatment. We dissect critical...
Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Although activator of HSP90 ATPase activity 1 (AHA1) reported to be a potential oncogene, its role osteosarcoma progression remains largely unclear. Since metabolism reprogramming involved tumorigenesis cancer metastasis, relationship between AHA1 unknown. In this study, we found that significantly overexpressed related prognosis patients. promotes growth metastasis both vitro vivo....
Curcumin (CUR), a widely used food additive, is derived mainly from<italic>Curcuma</italic>species that has been applied traditionally for treating hepatocellular carcinoma (HCC).
Current surveillance modalities of osteosarcoma relapse exhibit limited sensitivity and specificity. Although circulating tumor DNA (ctDNA) has been established as a biomarker minimal residual disease (MRD) in many solid tumors, sensitive ctDNA detection technique not thoroughly explored for longitudinal MRD osteosarcoma.
Abstract Recent studies have shown that ANXA2 is important in the development of many cancers, while its role glioma-related immune response remains unclear. We aimed to comprehensively investigate biological characteristics and clinical value glioma. analyzed 699 glioma samples from The Cancer Genome Atlas as training cohort 325 Chinese Glioma validation cohort. All statistical analyses figures were generated with R. was overexpressed significantly high-grade glioma, isocitrate...
Abstract Background Risk stratification and personalized care are crucial in managing osteosarcoma due to its complexity heterogeneity. However, current prognostic prediction using clinical variables has limited accuracy. Thus, this study aimed explore potential molecular biomarkers improve assessment. Methods High-throughput inhibitor screening of 150 compounds with broad targeting properties was performed indicated a direction towards super-enhancers (SEs). Bulk RNA-seq, scRNA-seq,...
Objectives: Chordoma, a rare malignant tumor, is notably resistant to conventional treatments including chemotherapy, radiotherapy, and targeted approaches. Immunotherapy, successful in treating other cancer types, presents promising avenue. However, the immune microenvironment of chordoma poorly understood, highlighting need investigate checkpoints their potential as therapeutic targets this context. Methods: We performed an integrated analysis using public datasets (GSE224776, GSE56183,...
Models of entire managed systems, known as operating models or management strategy evaluation (MSE) models, have been developed in recent years to more fully account for uncertainty multiple steps fishery management.Here we describe an model sea lamprey the Great Lakes and use compare alternative strategies control Lake Michigan.Control lampreys is mainly achieved through application chemical lampricides that target stream-dwelling larvae before they become parasites.The simulated due...
Parkinson's disease is recognized as the second most common neurodegenerative disorder after Alzheimer's disease, characterized by loss of dopominergic neurons in substantia nigra pars compacta and can be experimentally mimicked use neurotoxin, 1‑methyl‑4‑phenylpyridinium ion (MPP+), vitro models. In this study, we investigated potential protective effects apigenin (AP), galangin genkwanin, naturally occurring plant flavonoids, on MPP+‑induced cytotoxicity cultured rat adrenal...
Hair follicle neural crest stem cells reside in the bulge region of outer root sheath hair follicles, originate from ectoderm, and have multidirectional differentiation potential, making them ideal candidates for tissue engineering applications. These mainly a hypoxic microenvironment that favors maintenance stemness. Recently, many studies elucidated involvement Hippo pathway regulation cell fate. However, few investigated whether signaling regulates growth environments. In present study,...
Abstract We estimated economic injury levels (EILs) and associated optimal control budgets for sea lamprey Petromyzon marinus each of the Great Lakes using common assumptions consistent methods. The lake‐specific EILs are defined as equilibrium abundances below which incremental increases in expenditures do not pay themselves terms benefits (in form increased harvest desired host species). assume that efforts result an increase availability adult hosts fishery harvest, provides value to...