A5100371462- Gut microbiota and health
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Ginseng Biological Effects and Applications
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Congenital heart defects research
- Bipolar Disorder and Treatment
- Microtubule and mitosis dynamics
- Treatment of Major Depression
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Polysaccharides and Plant Cell Walls
- Pluripotent Stem Cells Research
- Clostridium difficile and Clostridium perfringens research
- Adenosine and Purinergic Signaling
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Nerve injury and regeneration
- Diet and metabolism studies
Nankai University
2025
University of Hong Kong
2021-2025
University of Hong Kong - Shenzhen Hospital
2021-2025
The University of Melbourne
2015-2024
Florey Institute of Neuroscience and Mental Health
2015-2024
Emory University
2024
Sichuan University
2024
First Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Guizhou Provincial People's Hospital
2023
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by trinucleotide repeat expansion in the huntingtin (HTT) gene, which expressed ubiquitously throughout brain and peripheral tissues. Whilst focus of much research has been on cognitive, psychiatric motor symptoms HD, extent pathology its potential impact central less intensely explored. Disruption gastrointestinal microbiome (gut dysbiosis) recently reported number neurological disorders, therefore we hypothesized...
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder with onset and severity of symptoms influenced by various environmental factors. Recent discoveries have highlighted the importance gastrointestinal microbiome in mediating gut-brain-axis bidirectional communication via circulating Using shotgun sequencing, we investigated gut composition R6/1 transgenic mouse model HD from 4 to 12 weeks age (early adolescent through adult stages). Targeted metabolomics was also...
Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby fluoxetine confers anti-depressive actions via 5-HT2BR is not fully understood. Although neuroinflammation-induced A1 astrocytes are involved in neurodegenerative diseases, role of astrocyte pathogenesis and treatment major depressive disorder (MDD) remains unclear.Mice were subjected chronic mild stress (CMS) for 6 weeks subsequently...
The manipulation of interfacial properties has broad implications for the development high-performance coatings. Metal-phenolic networks (MPNs) are an emerging class responsive, adherent materials. Herein, host-guest chemistry is integrated with MPNs to modulate their surface and properties. Macrocyclic cyclodextrins (host) conjugated catechol or galloyl groups subsequently used as components assembly functional MPNs. assembled cyclodextrin-based highly permeable (even high molecular weight...
Background Intestinal microbiota homeostasis and the gut-brain axis are key players associated with host health alterations in metabolic, inflammatory, neurodegenerative disorders. Sepsis-associated encephalopathy (SAE), which is closely bacterial translocation, a common secondary organ dysfunction an urgent, unsolved problem affecting patient quality of life. Our study examined neuroprotective effects gut microbiome short-chain fatty acid (SCFA) metabolites on SAE. Methods Male C57BL/6 mice...
Glutamatergic dysfunction has been implicated in the pathogenesis of depressive disorders and Huntington's disease (HD), which depression is most common psychiatric symptom. Synaptic glutamate homeostasis regulated by cystine-dependent transporters, including GLT-1 system xc- In HD, enzyme regulating cysteine (and subsequently cystine) production, cystathionine-γ-lygase, recently shown to be lowered. The aim present study was establish whether supplementation, using N-acetylcysteine (NAC)...
The locus coeruleus (LC)-norepinephrine (NE) system in the brainstem plays a critical role variety of behaviors is an important target pharmacological intervention to several neurological disorders. Although GABA major inhibitory neurotransmitter LC neurons, modulation neuronal firing activity by local GABAergic interneurons remains poorly understood with respect their precise location, intrinsic membrane properties and synaptic modulation. Here, we took optogenetic approach address these...
Astragalus membranaceus (Astragalus) is often used as a medical and food resource in China. The present study was designed to investigate the features effects of polysaccharide from (WAP) on rats with antibiotic-associated diarrhea (AAD). WAP mainly composed glucose, galactose, arabinose glacturonic acid, glucan, arabinogalactan RG-I regions, it showed loosely irregular sheet conformation. decreased inflammatory cell infiltration colon AAD rats, increased propionate butyrate production,...
Recent research has provided novel but contrary insight into the function of Slit2-Robo signaling in angiogenesis. Although role Robo choroidal neovascularization (CNV) been studied, effect its ligand, Slit2, on CNV development is unclear. This study investigated endogenous Slit2 and possible mechanisms.Laser-induced transgenic wild-type mice was used to effects angiogenesis vivo. Fluorescein angiography performed evaluate leakage area each lesion. Plasmid-based gene transfer technology...
The microtubule cytoskeleton is critical for the generation and maturation of neurons in developing mammalian nervous system. We have previously shown that mutations β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities humans. While it known necessary proper migration neurons, little understood role plays neuronal differentiation connectivity. Here, we report perturbations to disrupt morphology cortical their complexity, axonal outgrowth, as well density shape...
Disruptions to neuronal mRNA translation are hypothesized underlie human neurodevelopmental syndromes. Notably, the re-initiation factor DENR is a regulator of eukaryotic and cell growth, but its mammalian functions unknown. Here, we report that Denr influences migration murine cerebral cortical neurons in vivo with binding partner Mcts1, whereas perturbations impair long-term positioning, dendritic arborization, spine characteristics postnatal projection neurons. We characterized de novo...
In this study, the effects of ginseng water-soluble dietary fiber (ginseng-SDF) on metabolism, appetite and colon health in rats were investigated. The results showed that ginseng-SDF could improve glucolipid especially triglyceride levels. Ginseng-SDF also increased satiety delayed gastric emptying by regulating hormone levels as ghrelin, glucagon-like peptide-1, peptide YY, cholecystokinin. addition, improved intestinal structures enhanced fecal short-chain fatty acids concentrations...
Parkinson's disease is recognized as the second most common neurodegenerative disorder after Alzheimer's disease, characterized by loss of dopominergic neurons in substantia nigra pars compacta and can be experimentally mimicked use neurotoxin, 1‑methyl‑4‑phenylpyridinium ion (MPP+), vitro models. In this study, we investigated potential protective effects apigenin (AP), galangin genkwanin, naturally occurring plant flavonoids, on MPP+‑induced cytotoxicity cultured rat adrenal...
Metabotropic glutamate receptor 5 (mGlu5) has been implicated in certain forms of synaptic plasticity and cognitive function. mGlu5 knockout (KO) mice antagonists have previously used to study the pathophysiology schizophrenia as they shown respectively display or induce endophenotypes relevant schizophrenia. While presents with generalized impairments, phenotype lacking so far only explored using largely hippocampal-dependent spatial contextual memory tasks. To address this, we a...
Intraneuronal accumulation and extracellular deposition of amyloid-β (Aβ) protein continues to be implicated in the pathogenesis Alzheimer's disease (AD), it familial origin or sporadic nature. Aβ is generated intracellularly following endocytosis precursor (AβPP), and, consequently, factors that suppress AβPP internalization may decrease amyloidogenic processing AβPP. Here we tested hypothesis caffeine decreases generation by suppressing primary cultured neurons. Caffeine...