A5013702685- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Adenosine and Purinergic Signaling
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- Acute Ischemic Stroke Management
- Nuclear Receptors and Signaling
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Intracerebral and Subarachnoid Hemorrhage Research
- S100 Proteins and Annexins
- Adipose Tissue and Metabolism
- Youth Substance Use and School Attendance
- Cancer Research and Treatment
- Genetics and Neurodevelopmental Disorders
- Cellular transport and secretion
- Neuropeptides and Animal Physiology
- Barrier Structure and Function Studies
- Ferroptosis and cancer prognosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Circadian rhythm and melatonin
Nanjing Medical University
2018-2024
Augusta University
2021
China Pharmaceutical University
2012-2018
National Center for Drug Screening
2014
Emerging evidence suggests that astrocyte loss is one of the most important pathological features in hippocampus patients with major depressive disorder (MDD) and mice. Pyroptosis a recently discovered form programmed cell death depending on Caspase–gasdermin D (Casp-GSDMD), which involved multiple neuropsychiatric diseases. However, involvement pyroptosis onset MDD glial injury remains obscure. Here, we observed mice showed astrocytic pyroptosis, was responsible for loss, selective...
The function and regulation of different heterogeneous reactive states astrocytes in depression remain unclear. Here, we demonstrate that neurotoxic (A1-like) are strongly induced, prior to behavioral impairments dendritic atrophy, depression-like mice. More interestingly, global or microglia-specific knockout Nod-like receptor protein 3 (Nlrp3) markedly mitigates A1-like astrocyte induction, whereas astrocyte-specific Nlrp3 depletion is ineffective. Microglial ablation also alleviates the...
Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby fluoxetine confers anti-depressive actions via 5-HT2BR is not fully understood. Although neuroinflammation-induced A1 astrocytes are involved in neurodegenerative diseases, role of astrocyte pathogenesis and treatment major depressive disorder (MDD) remains unclear.Mice were subjected chronic mild stress (CMS) for 6 weeks subsequently...
Although β-arrestins (ARRBs) regulate diverse physiological and pathophysiological processes, their functions regulation in Parkinson's disease (PD) remain poorly defined. In this study, we show that the expression of β-arrestin 1 (ARRB1) 2 (ARRB2) is reciprocally regulated PD mouse models, particularly microglia. ARRB1 ablation ameliorates, whereas ARRB2 knockout aggravates, pathological features PD, including dopaminergic neuron loss, neuroinflammation microglia activation vivo,...
Interleukin-4 (IL-4)-exposed microglia acquire neuroprotective properties, but their functions and regulation in Parkinson's disease (PD) are poorly understood. In this study, we demonstrate that IL-4 enhances anti-inflammatory reactivity, ameliorates the pathological features of PD, reciprocally affects expression β-arrestin 1 2 PD mouse models. We also show manipulation two β-arrestins produces contrary effects on states action induced by vivo vitro. further find functional antagonism is...
Microglia have been proposed to play a pivotal role in the inflammation response of CNS by expressing range proinflammatory enzymes and cytokines under pathological stimulus. Our previous study has confirmed that Nogo receptor (NgR), an axon outgrowth inhibition receptor, is also expressed on microglia regulates cell adhesion migration behavior vitro. In present study, we further investigated effects possible mechanisms this peptide, Nogo-P4, 25-amino acid core inhibitory peptide sequence...
Alzheimer's disease (AD) is characterized by extracellular β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), and microglia-dominated neuroinflammation. The Nogo/NgR signal pathway involved in AD pathological features, but the detailed mechanism needs further investigation. Our previous studies have confirmed that activation of NgR on microglia Nogo promotes expression proinflammatory cytokines inhibits cell adhesion migration behaviors. In present study, we investigated effects...
Alzheimer's disease is characterized by progressive accumulation of β-amyloid (Aβ)-containing amyloid plaques, and microglia play a critical role in internalization degradation Aβ. Our previous research confirmed that Nogo-66 binding to Nogo receptors (NgR) expressed on inhibits cell adhesion migration vitro. The isolated from WT APP/PS1 mice different ages were measured assays transwells. After NEP1-40 (a competitive antagonist Nogo/NgR pathway) was intracerebroventricularly administered...
G protein–coupled receptors (GPCRs) are important modulators of synaptic functions. A fundamental but poorly addressed question in neurobiology is how targeted GPCR trafficking achieved. Rab GTPases the master regulators vesicle-mediated membrane trafficking, their functions presentation newly synthesized GPCRs virtually unknown. Here, we investigate role Rab43, via dominant-negative inhibition and CRISPR–Cas9–mediated KO, export α2-adrenergic receptor (α2-AR) muscarinic acetylcholine...
Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson’s disease (PD). As most abundant cells brain and active participants neuroinflammatory responses, astrocytes largely propagate signals amplify neuronal loss. Hence, intensive control astrocytic activation is necessary to prevent neurodegeneration. In this study, we report that kir6.2, as a abnormal response after stimuli, promotes reactivity A1 neurotoxic astrocytes. Using kir6.2 knockout (KO) mice, find...
Kir6.2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels, regulates functions metabolically active tissues and acts as an ideal therapeutic target for multiple diseases. Previous studies have been conducted on peripheral kir6.2, but its precise physiological roles in central nervous system (CNS) rarely revealed. In current study, we evaluated neurophenotypes neuroethology kir6.2 knockout (kir6.2−/−) mice. We demonstrated beneficial effects maintaining morphology...
To explore the synergistic antidepressant effect of quercetin and hyperforin (HF, extracted from Hypericum perforatum).Male ICR mice were divided into nine groups:blank control, positive control (Paroxetine, 10 mg/kg), groups (A: 5 mg/kg, B: C: 20 perforatum extract (HF mg/kg),combination 2.5 mg/kg + HF mg/kg,B:quercetin mg/kg,C: mg/kg). All drugs administered intragastrically. Reserpine reversal tests used to compare effects on body temperature decline, eyelid ptosis akinesia. Tail...
Microglia plays a critical role in the brain aging process and Alzheimer's disease (AD). It has been reported ability of microglia to clear Aβ decreases with age progression AD pathology. Nogo-A/NgR signaling pathway not only arreste neurite outgrowth but also involve NgR expressed on neuron expresses mediates neuroinflammation via modulating adhesion migration. Therefore i n present study we would like explore migration A β deposition during vitro. Adhesion assay, Boyden chamber assay...
Abstract Background Although β-arrestins (ARRBs) regulate diverse physiological and pathophysiological processes, their function regulation in Parkinson’s disease (PD) remain poorly defined. Methods We measured expression of ARRB1 ARRB2 liposaccharide (LPS)-induced 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD mice. ARRB1-deficient ARRB2-deficient mouse were used to assess the impact ARRBs on dopaminergic (DA) neuron loss microglia activation models. After primary DA...