A5100700414- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Adenosine and Purinergic Signaling
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Bone health and treatments
- Metabolism, Diabetes, and Cancer
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Marine and coastal ecosystems
- Autophagy in Disease and Therapy
- Birth, Development, and Health
- Chromium effects and bioremediation
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Erythrocyte Function and Pathophysiology
- Pancreatic function and diabetes
- Cannabis and Cannabinoid Research
- Advanced biosensing and bioanalysis techniques
- Trace Elements in Health
- RNA Interference and Gene Delivery
- Environmental Changes in China
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
Nanjing Medical University
2018-2025
University of Chinese Academy of Sciences
2020-2025
Institute of Geographic Sciences and Natural Resources Research
2025
Chinese Academy of Sciences
2019-2025
Wenzhou Medical University
2024-2025
Hangzhou DAC Biotech (China)
2024-2025
The University of Texas at Austin
2024
Changchun Institute of Technology
2024
Hunan Children's Hospital
2024
Central South University
2023-2024
Aging-related, nonresolving inflammation in both the central nervous system (CNS) and periphery predisposes individuals to development of neurodegenerative disorders (NDDs). Inflammasomes are thought be especially relevant immune homeostasis, their dysregulation contributes NDDs. However, few agents have been clinically shown reduce NDD incidence by targeting inflammasomes. Our study indicated that NLRP3 (NLR family, pyrin domain containing 3) inflammasome is involved Parkinson disease (PD)...
Abstract Oxidative stress is a major pathogenic mechanism in Parkinson’s disease (PD). As an important cellular antioxidant, glutathione (GSH) balances the production and incorporation of free radicals to protect neurons from oxidative damage. GSH level decreased brains PD patients. Hence, clarifying molecular deficiency may help deepen our knowledge pathogenesis. Here we report that astrocytic dopamine D2 receptor (DRD2) regulates synthesis via PKM2-mediated Nrf2 transactivation. In...
Background: Transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of alveolar epithelial cells (AEC) may contribute to idiopathic pulmonary fibrosis (IPF). TGF-β1-induced EMT in A549 (a human AEC cell line) resulted the adoption mesenchymal responses that were predominantly mediated via TGF-β1-Smad2/3 signaling pathway. Simvastatin (Sim), a 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase inhibitor, has been previously reported inhibit proximal tubular and...
Parkinson's disease (PD) is a neurodegenerative disorder with progressive loss of dopaminergic (DA) neurons. Systemic inflammation shown to initiate and exacerbate DA neuronal degeneration in the substantia nigra. The infiltration transformation immune cells from peripheral tissues are detected around affected brain regions PD patients. Our previous studies demonstrated crucial role that microglial Nod-like receptor protein (NLRP) 3 inflammasome plays pathogenesis PD. Nevertheless, direct...
Preeclampsia (PE) refers to a syndrome of new-onset hypertension with multisystem involvement and damage after 20 weeks gestation. Defective placentation due dysregulated behaviors trophoblast cells is considered predominant cause PE.Immunofluorescence (if) Western blot were used detect the expression localization Carnitine palmitoyltransferase 1A (CPT1A) in placenta. CPT1A protein was overexpressed/knocked down HTR8/SVneo by lentiviral/siRNA interference method. CCK-8 Assay, blot, flow...
Land use classification remains a significant challenge in remote sensing semantic segmentation. While convolutional neural networks (CNNs) are widely used, their inherent limitations, such as restricted receptive fields, hinder widespread application sensing. Additionally, the scarcity of labeled data and domain shift issues adversely impact deep learning model performance. This study proposes hierarchical transfer framework for fine-category segmentation tasks, leveraging powerful global...
Introduction: Autophagy-lysosome pathways play a crucial role in the intracellular killing of pathogenic microorganisms. This study aimed to explore mechanism by which acute lung injury (ALI) Pseudomonas aeruginosa affects autophagy-lysosome pathway. Methods: ALI mouse models were induced lipopolysaccharide and P. strain K (PAK). Lung tissue sections stained with hematoxylin-eosin for observation. Flow cytometry was used analyze bacteria inflammatory cell infiltration. ELISA performed...
Abstract B7-H3 (also known as CD276), a member of the B7 ligand family, is overexpressed on differentiated malignant cells and cancer-initiating cells, with limited heterogeneity, high frequency (60% 25,000 tumor samples), such prostate cancer, non-small cell lung cancer (NSCLC), melanoma, bladder breast clear renal carcinoma, head neck squamous (HNSCC), but scarcely detected in normal tissues. PSMA highly expressed endothelial neovasculature several solid human malignancies. High expression...
Peripheral blood immune cells have different molecular characteristics at stages of the whole lifespan. Knowledge circulating cell types and states from children to centenarians remains incomplete. We profiled peripheral mononuclear (PBMCs) multiple age groups with single-cell RNA sequencing (scRNA-seq), involving ranges 1-12 (G1), 20-30(G2), 30-60(G3), 60-80(G4), >110 years (G5). The proportion myeloid change significantly G1 G2. identified a novel CD8 + CCR7 GZMB cytotoxic T subtype...
Stress granules (SGs) and processing-bodies (PBs, P-bodies) are ubiquitous widely studied ribonucleoprotein (RNP) involved in cellular stress response, viral infection, the tumor microenvironment. While proteomic transcriptomic investigations of SGs PBs have provided insights into molecular composition, chemical tools to probe modulate RNP remain lacking. Herein, we combine an immunofluorescence (IF)-based phenotypic screen with chemoproteomics identify sulfonyl-triazoles (SuTEx) capable...
Functional metagenomics is a premise-free approach for exploring metal resistance genes, enabling more profound effects on the development of bioremediation tools than pure culture based selection. Six soil metagenomic libraries were screened copper (Cu) genes in current study through conventional functional genomics. Clones from six randomly selected solid medium supplied with Cu, resulting 411 Cu clones. Thirty-five clones strongest sequenced and 12 unique sequences harboring 25 putative...
Background: A recent study has reported that maternal obesity is linked to placental oxidative damage and premature senescence. NADPH oxidase 4 (NOX4) massively expressed in adipose tissue, its induced reactive oxygen species have been found contribute cellular While, whether, obese pregnancy, tissue-derived NOX4 the considerable cause of senescence remained elusive. Methods: This collected term placentas from normal pregnancies pregnant mouse model was constructed by a high fat diet explore...
Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer with major challenges in both prevention and therapy. Metformin, adenosine monophosphate-activated protein kinase (AMPK) activator, has been suggested to reduce the incidence of HCC when used for patients diabetes preclinical clinical studies. However, possible effects metformin their mechanisms action non-diabetic have not adequately investigated.