A5101932029- Heart Rate Variability and Autonomic Control
- Sleep and related disorders
- Sleep and Work-Related Fatigue
- Vagus Nerve Stimulation Research
- Circadian rhythm and melatonin
- Dermatology and Skin Diseases
- Blood Pressure and Hypertension Studies
- Acupuncture Treatment Research Studies
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Cardiovascular Health and Risk Factors
- Cardiovascular and exercise physiology
- Neuropeptides and Animal Physiology
- Cardiac Health and Mental Health
- CAR-T cell therapy research
- Healthcare and Venom Research
- Nicotinic Acetylcholine Receptors Study
- Psoriasis: Treatment and Pathogenesis
- Mindfulness and Compassion Interventions
- Non-Invasive Vital Sign Monitoring
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermoregulation and physiological responses
- Diet and metabolism studies
- Allergic Rhinitis and Sensitization
- Anesthesia and Pain Management
Children's Hospital of Chongqing Medical University
2008-2025
Chongqing Medical University
2008-2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
State Key Laboratory of Medical Neurobiology
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2024
Fudan University
2023-2024
Huashan Hospital
2024
Fuyang City People's Hospital
2024
Hunan Normal University
2023-2024
Efferent activity in the vagus nerve can prevent endotoxin-induced shock by attenuating tumor necrosis factor (TNF) synthesis. Termed “cholinergic antiinflammatory pathway,” inhibition of TNF synthesis is dependent on nicotinic α-bungarotoxin-sensitive acetylcholine receptors macrophages. Vagus firing also stimulated CNI-1493, a tetravalent guanylhydrazone molecule that inhibits systemic inflammation. Here, we studied effects pharmacological and electrical stimulation intact adult male Lewis...
The cholinergic antiinflammatory pathway modulates Inflammatory cytokine production through a mechanism dependent on the vagus nerve and α7 subunit of nicotinic acetylcholine receptor. GTS-21 [3-(2,4-dimethoxybenzylidene) anabaseine], selective agonist, inhibits inflammatory in murine human macrophages several models disease vivo, but to date its efficacy monocytes has not been characterized. We report here our findings that attenuates tumor necrosis factor (TNF) interleukin 1β levels whole...
Sleep deprivation has been linked to hypertension, and recent evidence suggests that associations between short sleep duration hypertension are stronger in women. In the present study we hypothesized 24 h of total (TSD) would elicit an augmented pressor sympathetic neural response women compared with men. Resting heart rate (HR), blood pressure (BP), muscle nerve activity (MSNA) were measured 30 healthy subjects (age, 22 ± 1; 15 men women). Relations spontaneous fluctuations diastolic...
Blood pressure (BP) dips at night during sleep in healthy individuals but disturbed sleep, dipping is blunted. However, the impact of chronic insufficient duration, with limited intermittent recovery on BP not known. The objective this study was to examine, a controlled experimental model, influence restriction patterns and day.In highly 22-day in-hospital protocol, 45 participants (age 32 ± 2 years; BMI 24 1 kg/m; 22 men 23 women) were randomly assigned one two conditions: repeated (4 h...
Preeclampsia (PE) refers to a syndrome of new-onset hypertension with multisystem involvement and damage after 20 weeks gestation. Defective placentation due dysregulated behaviors trophoblast cells is considered predominant cause PE.Immunofluorescence (if) Western blot were used detect the expression localization Carnitine palmitoyltransferase 1A (CPT1A) in placenta. CPT1A protein was overexpressed/knocked down HTR8/SVneo by lentiviral/siRNA interference method. CCK-8 Assay, blot, flow...
Background. Acupuncture is often used for primary dysmenorrhea. Objective. To assess the efficacy of a single point acupuncture in management dysmenorrhea compared with sham and no acupuncture. Methodology. Patients were randomly assigned to acupoint group (n = 50), unrelated nonacupoint 46), or 48). administered once-daily 3 days electro-acupuncture at Sanyinjiao (SP6) that was specifically designed treat dysmenorrhea, an (Xuanzhong, GB39), location. The outcome pain intensity as measured...
Exaggerated cardiovascular reactivity to mental stress (MS) and cold pressor test (CPT) has been linked increased risk of disease. Recent epidemiological studies identify sleep deprivation as an important factor for hypertension, yet the relations between remain equivocal. We hypothesized that 24-h total (TSD) would augment MS CPT blunt MS-induced forearm vasodilation. Because associations TSD hypertension appear be stronger in women, a secondary aim was probe sex differences. Mean arterial...
Obesity and its accompanying metabolic syndrome are strongly associated with heightened morbidity mortality in older adults. In our review of more than 20 epidemiologic studies major infectious diseases, including tuberculosis, community-acquired pneumonia sepsis, obesity was better outcomes. A cause-and-effect relationship between over-nutrition survival infection is suggested by the results two preliminary infections mice, where high-fat feeding for 8–10 wks provided much These outcomes...
ABSTRACT Intervertebral disc (IVD) degeneration (DD) is associated with low back pain, the leading cause of disability worldwide. Damage‐associated molecular patterns (DAMPs) that contribute to inflammation and trigger DD have not been well characterized. Extracellular high mobility group box‐1 (HMGB1) protein has implicated as a potent DAMP pro‐inflammatory stimulus in immune system. In this study, we show HMGB1 IL‐6 levels increase patients advanced comparison early DD. This study further...
Allergens have been identified as potential triggers in patients with atopic dermatitis (AD). Patients AD are highly sensitive to cockroach allergen. The underlying mechanism, however, remains undetermined. Here, we established a allergen–induced AD-like mouse model, and demonstrate that repeated exposure allergen led aggravated skin inflammation, characterized by increased type 2 immunity, innate lymphoid cells (ILC2s), mast cells. Increased were also observed AD. Mast cell–deficient mice...
Mental stress elicits a robust and consistent forearm vasodilation, but vascular reactivity in the calf remains inconsistent. It has been reported that responses to MS may be sex dependent. Muscle sympathetic nerve activity (MSNA) is an important contributor blood flow (CBF), yet relations between sex, limb flow, MSNA mental have not explored. We hypothesized would elicit more dramatic vasodilation of limbs women this might explained by reduced and/or blunted transduction. measured heart...
Recent evidence suggests that young men and women may have different strategies for regulating arterial blood pressure, the purpose of present study was to determine if sex differences exist in diastolic pressure (DAP) muscle sympathetic nerve activity (MSNA) relations during simulated orthostatic stress. We hypothesized would demonstrate stronger DAP-MSNA coherence a greater percentage "consecutive integrated bursts" Fourteen 14 (age 23 ± 1 yr) were examined at rest progressive lower body...
Although CD4+ T cells are known to contribute the pathology of atopic dermatitis (AD), role helper 17 and interleukin (IL)-17 in skin inflammation remains poorly understood. The aim this study was characterize IL-17 AD-related immunopathology.Blood samples were collected from 87 children with AD 60 healthy control subjects. In addition, 10 biopsies each group collected. Skin serum expression levels analyzed by immunohistochemistry enzyme-linked immunosorbent assay, respectively....
Blunted dipping of nocturnal systolic arterial pressure (SAP) and heart rate (HR) are independent risk factors for hypertension all-cause mortality. While several epidemiological studies report a significant association between short sleep duration hypertension, associations efficiency the drop SAP remain controversial. Moreover, relations HR diurnal patterns have been overlooked. We hypothesized that low (<85%) would be associated with blunted dipping. Twenty-two normotensive subjects (13...
The use of spontaneous bursts muscle sympathetic nerve activity (MSNA) to assess arterial baroreflex control has seen increased utility in studies both health and disease. However, methods used for analyzing MSNA sensitivity are highly variable across published studies. Therefore, we sought comprehensively examine producing linear regression slopes quantify a large cohort subjects ( n = 150) support standardized procedure analysis that would allow consistent comparable results laboratories....