A5017107752- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Appendicitis Diagnosis and Management
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Turtle Biology and Conservation
- Pregnancy-related medical research
- Genetic factors in colorectal cancer
- Rabies epidemiology and control
- Osteoarthritis Treatment and Mechanisms
- Colorectal and Anal Carcinomas
- Veterinary Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- DNA and Nucleic Acid Chemistry
- Pain Mechanisms and Treatments
- Central Venous Catheters and Hemodialysis
- Spondyloarthritis Studies and Treatments
- Gastrointestinal disorders and treatments
- RNA Interference and Gene Delivery
Northwestern University
2022
Hofstra University
2018-2019
Jewish Hospital
2018
Northwell Health
2016-2018
Feinstein Institute for Medical Research
2015-2016
Drexel University
2011
St. Joseph’s University Medical Center
1989
St. Joseph's Hospital and Medical Center
1989
Many intervertebral disc diseases cause low back pain (LBP). Proinflammatory cytokines and matrix metalloproteinases (MMPs) participate in pathology. In this study, we examined levels of serum MMPs human subjects with diagnoses herniation (DH), spinal stenosis (SS), or degenerative disease (DDD) relative to control subjects. Comparison between DH those other (Other Dx, grouped from SS DDD) was performed elaborate a pathological mechanism based on circulating cytokine levels. Study...
Abstract Molecular events that drive disc damage and low back pain (LBP) may precede clinical manifestation of disease onset can cause detrimental long-term effects such as disability. Biomarkers serve objective molecular indicators pathological processes. The goal this study is to identify systemic biochemical factors predictors response treatment LBP with epidural steroid injection (ESI). Since inflammation plays a pivotal role in LBP, pilot investigates the effect ESI on levels 48...
ABSTRACT Intervertebral disc (IVD) degeneration (DD) is associated with low back pain, the leading cause of disability worldwide. Damage‐associated molecular patterns (DAMPs) that contribute to inflammation and trigger DD have not been well characterized. Extracellular high mobility group box‐1 (HMGB1) protein has implicated as a potent DAMP pro‐inflammatory stimulus in immune system. In this study, we show HMGB1 IL‐6 levels increase patients advanced comparison early DD. This study further...
Introduction Molecular events that drive disc damage and low back pain (LBP) may precede clinical manifestation of disease onset can cause detrimental long-term effects such as disability. Biomarkers serve objective molecular indicators pathological processes. The goal this study is to identify systemic biochemical factors predictors response treatment LBP with epidural steroid injection (ESI). Since inflammation plays a pivotal role in LBP, pilot investigates the effect ESI on levels 51...
Introduction Many intervertebral disc diseases cause low back pain (LBP). Pro-inflammatory cytokines and matrix metalloproteinases (MMPs) participate in pathology. This study examines levels of serum MMPs human subjects with diagnosis herniation (DH), spinal stenosis (SS) or degenerative disease (DDD) relative to control subjects. Comparison between DH versus other diagnoses (Other Dx, grouped from SS DDD) was performed elaborate a pathological mechanism based on systemic cytokine levels....